ENSG00000154832

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000285106 ENSG00000154832 HEK293_OSMI2_2hA HEK293_TMG_2hB CXXC1 protein_coding protein_coding 62.92548 80.40033 46.91068 3.804321 0.8704452 -0.777157 35.549813 55.697925 23.824827 1.86595910 0.05011937 -1.2248114 0.54847500 0.69366667 0.50826667 -0.18540000 7.477790e-13 8.01785e-15 FALSE TRUE
ENST00000586144 ENSG00000154832 HEK293_OSMI2_2hA HEK293_TMG_2hB CXXC1 protein_coding retained_intron 62.92548 80.40033 46.91068 3.804321 0.8704452 -0.777157 3.071747 2.857303 2.561852 0.77006910 0.52006367 -0.1568866 0.05036250 0.03486667 0.05436667 0.01950000 4.421997e-01 8.01785e-15 FALSE FALSE
ENST00000586568 ENSG00000154832 HEK293_OSMI2_2hA HEK293_TMG_2hB CXXC1 protein_coding retained_intron 62.92548 80.40033 46.91068 3.804321 0.8704452 -0.777157 3.134381 1.645813 2.981129 0.03178197 0.08921947 0.8531500 0.05357083 0.02053333 0.06350000 0.04296667 8.017850e-15 8.01785e-15 FALSE FALSE
ENST00000592078 ENSG00000154832 HEK293_OSMI2_2hA HEK293_TMG_2hB CXXC1 protein_coding retained_intron 62.92548 80.40033 46.91068 3.804321 0.8704452 -0.777157 4.818120 2.286967 4.713452 0.51836543 0.80060363 1.0401117 0.08222500 0.02816667 0.10080000 0.07263333 1.682939e-03 8.01785e-15   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000154832 E001 0.5483223 0.0217681645 8.605441e-01 9.140619e-01 18 50282343 50282346 4 - 0.180 0.150 -0.315
ENSG00000154832 E002 1.3953073 0.0098464605 8.116088e-01 8.804339e-01 18 50282347 50282348 2 - 0.307 0.350 0.268
ENSG00000154832 E003 7.9288154 0.0547570807 1.613750e-01 2.768803e-01 18 50282349 50282363 15 - 0.708 0.951 0.951
ENSG00000154832 E004 282.0128402 0.0026011728 1.015506e-02 2.914564e-02 18 50282364 50282532 169 - 2.321 2.410 0.294
ENSG00000154832 E005 297.1369216 0.0019531575 7.103798e-03 2.149726e-02 18 50282533 50282579 47 - 2.346 2.431 0.284
ENSG00000154832 E006 543.5153621 0.0001444145 3.939441e-12 8.760597e-11 18 50282580 50282739 160 - 2.575 2.700 0.414
ENSG00000154832 E007 412.3339168 0.0008066373 9.035780e-07 7.573337e-06 18 50282854 50282906 53 - 2.461 2.579 0.393
ENSG00000154832 E008 517.8875326 0.0004344180 2.058185e-04 9.889342e-04 18 50282907 50283006 100 - 2.596 2.668 0.240
ENSG00000154832 E009 19.8765905 0.0024637239 4.009695e-16 1.595180e-14 18 50283007 50283079 73 - 1.635 0.994 -2.249
ENSG00000154832 E010 16.1844568 0.0157795500 3.120975e-11 5.991077e-10 18 50283080 50283105 26 - 1.562 0.883 -2.419
ENSG00000154832 E011 27.3761038 0.0008676019 8.543850e-21 6.023843e-19 18 50283106 50283264 159 - 1.760 1.139 -2.145
ENSG00000154832 E012 412.2972720 0.0006038765 1.800411e-03 6.601042e-03 18 50283265 50283324 60 - 2.500 2.570 0.231
ENSG00000154832 E013 336.4489686 0.0002282342 6.870800e-02 1.412261e-01 18 50283325 50283361 37 - 2.435 2.473 0.128
ENSG00000154832 E014 32.4124730 0.0006575734 2.870987e-18 1.492590e-16 18 50283362 50283514 153 - 1.790 1.253 -1.843
ENSG00000154832 E015 372.0404124 0.0003491864 4.164454e-01 5.597963e-01 18 50283515 50283564 50 - 2.495 2.510 0.050
ENSG00000154832 E016 40.0068728 0.0006472740 1.179511e-15 4.410872e-14 18 50283565 50283652 88 - 1.835 1.382 -1.543
ENSG00000154832 E017 33.5973970 0.0095431210 7.421005e-12 1.577699e-10 18 50283653 50283704 52 - 1.797 1.274 -1.793
ENSG00000154832 E018 496.2994069 0.0017371323 4.752844e-01 6.140080e-01 18 50283705 50283815 111 - 2.621 2.637 0.053
ENSG00000154832 E019 13.5773354 0.0014393907 1.062515e-05 7.018324e-05 18 50283816 50283893 78 - 1.364 0.956 -1.458
ENSG00000154832 E020 645.3850454 0.0001368775 1.992279e-03 7.202586e-03 18 50283894 50284101 208 - 2.710 2.757 0.158
ENSG00000154832 E021 261.7874742 0.0001678468 1.511623e-02 4.074968e-02 18 50284378 50284384 7 - 2.310 2.368 0.196
ENSG00000154832 E022 236.3001644 0.0001865363 4.243743e-02 9.551549e-02 18 50284385 50284388 4 - 2.272 2.323 0.171
ENSG00000154832 E023 287.4792809 0.0001799590 2.210185e-02 5.588652e-02 18 50284389 50284428 40 - 2.356 2.409 0.176
ENSG00000154832 E024 514.5024218 0.0001372433 1.704595e-01 2.887535e-01 18 50284429 50284562 134 - 2.631 2.653 0.072
ENSG00000154832 E025 15.0093415 0.0011904687 4.402414e-01 5.819179e-01 18 50284720 50284731 12 - 1.201 1.126 -0.269
ENSG00000154832 E026 501.5532650 0.0001850290 7.484891e-01 8.357244e-01 18 50284732 50284839 108 - 2.634 2.637 0.010
ENSG00000154832 E027 665.3471726 0.0005756734 4.315200e-02 9.682368e-02 18 50285002 50285220 219 - 2.788 2.749 -0.132
ENSG00000154832 E028 265.5357414 0.0002719936 1.022535e-02 2.932028e-02 18 50285221 50285247 27 - 2.409 2.342 -0.223
ENSG00000154832 E029 14.9951965 0.0020360178 3.604940e-08 3.994999e-07 18 50285248 50285324 77 - 1.451 0.966 -1.724
ENSG00000154832 E030 218.4610736 0.0002162368 2.373125e-01 3.710643e-01 18 50285325 50285351 27 - 2.302 2.267 -0.118
ENSG00000154832 E031 12.2778187 0.0121486129 7.915997e-07 6.720420e-06 18 50285352 50285445 94 - 1.382 0.858 -1.896
ENSG00000154832 E032 272.1848112 0.0007331239 5.261091e-01 6.593837e-01 18 50285749 50285803 55 - 2.387 2.366 -0.068
ENSG00000154832 E033 310.0243346 0.0010962822 2.384022e-01 3.722857e-01 18 50285804 50285928 125 - 2.404 2.434 0.100
ENSG00000154832 E034 8.8069180 0.0403166037 5.136867e-03 1.630093e-02 18 50285929 50286021 93 - 1.187 0.793 -1.466
ENSG00000154832 E035 335.5739874 0.0022257726 6.564651e-01 7.660178e-01 18 50286022 50286180 159 - 2.453 2.465 0.040
ENSG00000154832 E036 375.3045394 0.0020733773 2.784569e-01 4.181278e-01 18 50286181 50286257 77 - 2.535 2.501 -0.113
ENSG00000154832 E037 3.7840239 0.0345170091 2.487168e-03 8.725677e-03 18 50286258 50286330 73 - 0.940 0.455 -2.056
ENSG00000154832 E038 474.9232504 0.0006771551 5.305227e-04 2.273633e-03 18 50286539 50286639 101 - 2.668 2.591 -0.255
ENSG00000154832 E039 446.9248112 0.0009973863 7.413745e-05 3.999635e-04 18 50286740 50286858 119 - 2.655 2.560 -0.316
ENSG00000154832 E040 9.4002204 0.0358783103 1.569681e-06 1.249040e-05 18 50286859 50287115 257 - 1.333 0.678 -2.448
ENSG00000154832 E041 8.1870254 0.0110832461 2.898180e-12 6.595214e-11 18 50287423 50287508 86 - 1.354 0.514 -3.252
ENSG00000154832 E042 7.8408254 0.0441126742 2.156849e-04 1.031215e-03 18 50287509 50287586 78 - 1.229 0.688 -2.041
ENSG00000154832 E043 241.7771961 0.0025587653 2.609753e-05 1.575306e-04 18 50287587 50287839 253 - 2.424 2.278 -0.489