ENSG00000154814

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000285083 ENSG00000154814 HEK293_OSMI2_2hA HEK293_TMG_2hB OXNAD1 protein_coding protein_coding 12.22827 8.181475 13.96611 1.265919 0.4519274 0.7707675 0.7353445 0.9551482 0.0000000 0.2464297 0.0000000 -6.5926786 0.06671667 0.11340000 0.00000000 -0.11340000 1.954478e-19 1.954478e-19 FALSE TRUE
ENST00000605932 ENSG00000154814 HEK293_OSMI2_2hA HEK293_TMG_2hB OXNAD1 protein_coding protein_coding 12.22827 8.181475 13.96611 1.265919 0.4519274 0.7707675 1.7870492 1.0872224 2.6418782 0.5715809 0.3684206 1.2731586 0.14330833 0.13286667 0.19083333 0.05796667 7.282544e-01 1.954478e-19 FALSE TRUE
ENST00000627468 ENSG00000154814 HEK293_OSMI2_2hA HEK293_TMG_2hB OXNAD1 protein_coding protein_coding 12.22827 8.181475 13.96611 1.265919 0.4519274 0.7707675 0.7430465 0.1497186 1.9304781 0.1497186 0.1702190 3.6028083 0.05652500 0.02123333 0.13770000 0.11646667 7.771191e-02 1.954478e-19 FALSE TRUE
MSTRG.22543.1 ENSG00000154814 HEK293_OSMI2_2hA HEK293_TMG_2hB OXNAD1 protein_coding   12.22827 8.181475 13.96611 1.265919 0.4519274 0.7707675 0.7498223 0.5775368 0.3896571 0.3617080 0.1849000 -0.5559164 0.06516250 0.06270000 0.02880000 -0.03390000 8.483433e-01 1.954478e-19 FALSE TRUE
MSTRG.22543.10 ENSG00000154814 HEK293_OSMI2_2hA HEK293_TMG_2hB OXNAD1 protein_coding   12.22827 8.181475 13.96611 1.265919 0.4519274 0.7707675 1.5137995 1.2668438 1.0255403 0.6926714 0.5622821 -0.3021984 0.12702500 0.14373333 0.07603333 -0.06770000 9.051990e-01 1.954478e-19 FALSE TRUE
MSTRG.22543.11 ENSG00000154814 HEK293_OSMI2_2hA HEK293_TMG_2hB OXNAD1 protein_coding   12.22827 8.181475 13.96611 1.265919 0.4519274 0.7707675 1.5998620 0.0000000 2.6952727 0.0000000 1.3717413 8.0796302 0.10362500 0.00000000 0.18743333 0.18743333 2.263592e-01 1.954478e-19 FALSE TRUE
MSTRG.22543.7 ENSG00000154814 HEK293_OSMI2_2hA HEK293_TMG_2hB OXNAD1 protein_coding   12.22827 8.181475 13.96611 1.265919 0.4519274 0.7707675 2.3859677 2.0616227 2.8126910 0.3290410 0.7297969 0.4463100 0.19574167 0.27330000 0.20193333 -0.07136667 7.706527e-01 1.954478e-19 FALSE TRUE
MSTRG.22543.9 ENSG00000154814 HEK293_OSMI2_2hA HEK293_TMG_2hB OXNAD1 protein_coding   12.22827 8.181475 13.96611 1.265919 0.4519274 0.7707675 0.5516971 0.5264418 0.2915049 0.0840193 0.1809432 -0.8312402 0.05014583 0.06756667 0.02100000 -0.04656667 3.391831e-01 1.954478e-19 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000154814 E001 0.4407149 0.0211475443 0.80838112 0.87827825 3 16265160 16265201 42 + 0.188 0.143 -0.481
ENSG00000154814 E002 1.2533463 0.0104904192 0.34637893 0.49052115 3 16265202 16265205 4 + 0.420 0.250 -1.065
ENSG00000154814 E003 1.5436917 0.0097121246 0.16213306 0.27790153 3 16265206 16265206 1 + 0.502 0.250 -1.479
ENSG00000154814 E004 2.4754845 0.0059050201 0.18346893 0.30555415 3 16265207 16265209 3 + 0.630 0.408 -1.065
ENSG00000154814 E005 2.6969297 0.0056566829 0.32700869 0.47045415 3 16265210 16265211 2 + 0.630 0.470 -0.743
ENSG00000154814 E006 3.9053358 0.0048051002 0.73366560 0.82483321 3 16265212 16265217 6 + 0.706 0.654 -0.216
ENSG00000154814 E007 4.0505085 0.0067757452 0.62512855 0.74131581 3 16265218 16265219 2 + 0.728 0.654 -0.308
ENSG00000154814 E008 5.7006616 0.0449307311 0.80107148 0.87322993 3 16265220 16265224 5 + 0.843 0.786 -0.223
ENSG00000154814 E009 13.3390048 0.0185565483 0.78142624 0.85958157 3 16265225 16265231 7 + 1.172 1.130 -0.148
ENSG00000154814 E010 14.2924538 0.0088521038 0.81789521 0.88484461 3 16265232 16265232 1 + 1.195 1.166 -0.104
ENSG00000154814 E011 69.5840394 0.0004860723 0.46671382 0.60626393 3 16265233 16265465 233 + 1.837 1.866 0.099
ENSG00000154814 E012 47.7818830 0.0005257829 0.97865538 0.99076505 3 16265466 16265505 40 + 1.691 1.689 -0.006
ENSG00000154814 E013 87.6740406 0.0003940141 0.94740230 0.97093831 3 16269126 16269275 150 + 1.954 1.951 -0.008
ENSG00000154814 E014 5.9064958 0.0027557752 0.04560759 0.10131353 3 16270929 16270944 16 + 0.948 0.690 -1.017
ENSG00000154814 E015 95.7676439 0.0003185882 0.26251191 0.40029696 3 16270945 16271071 127 + 2.009 1.970 -0.132
ENSG00000154814 E016 0.0000000       3 16271072 16271195 124 +      
ENSG00000154814 E017 73.3721692 0.0004016271 0.27857193 0.41824534 3 16271659 16271722 64 + 1.896 1.852 -0.149
ENSG00000154814 E018 4.5164820 0.0037194283 0.26757988 0.40590459 3 16272145 16272321 177 + 0.809 0.654 -0.633
ENSG00000154814 E019 76.3740225 0.0003693893 0.89579378 0.93742823 3 16286342 16286448 107 + 1.896 1.890 -0.019
ENSG00000154814 E020 87.5745208 0.0003061783 0.23078953 0.36341136 3 16294856 16294997 142 + 1.933 1.977 0.146
ENSG00000154814 E021 119.6978363 0.0003215991 0.94028354 0.96650116 3 16301626 16301868 243 + 2.088 2.091 0.008
ENSG00000154814 E022 80.8275424 0.0003945138 0.44578838 0.58732941 3 16302640 16302748 109 + 1.908 1.938 0.100
ENSG00000154814 E023 44.7107065 0.0004976771 0.20509966 0.33253327 3 16303408 16303410 3 + 1.635 1.700 0.220
ENSG00000154814 E024 100.0650670 0.0003201226 0.11752059 0.21640041 3 16303411 16303592 182 + 1.985 2.038 0.178
ENSG00000154814 E025 66.6584453 0.0004390245 0.27993094 0.41973025 3 16303593 16304826 1234 + 1.854 1.807 -0.158
ENSG00000154814 E026 62.4627303 0.0103958581 0.58822971 0.71144791 3 16304827 16306087 1261 + 1.821 1.792 -0.099
ENSG00000154814 E027 2.2164714 0.0084763533 0.35578984 0.50014610 3 16319461 16319615 155 + 0.420 0.572 0.744
ENSG00000154814 E028 3.0611791 0.0051587277 0.05748674 0.12232186 3 16322397 16322535 139 + 0.463 0.754 1.296
ENSG00000154814 E029 3.1449126 0.1211438591 0.04127657 0.09338766 3 16323099 16323177 79 + 0.373 0.786 1.909
ENSG00000154814 E030 0.2987644 0.0277034495 0.33315607   3 16330073 16330141 69 + 0.189 0.000 -9.787
ENSG00000154814 E031 9.0773743 0.0123717816 0.29501107 0.43612485 3 16337112 16337361 250 + 1.064 0.942 -0.451
ENSG00000154814 E032 7.8479593 0.0022061485 0.68528907 0.78806588 3 16343493 16343653 161 + 0.935 0.981 0.171
ENSG00000154814 E033 2.2904561 0.0089353110 0.91842189 0.95244970 3 16347597 16348032 436 + 0.537 0.523 -0.068
ENSG00000154814 E034 12.0565399 0.0044572772 0.88840387 0.93265201 3 16349176 16350299 1124 + 1.121 1.104 -0.064
ENSG00000154814 E035 0.9191074 0.0132957927 0.70003164 0.79961227 3 16384465 16384538 74 + 0.320 0.250 -0.481