ENSG00000154723

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000284971 ENSG00000154723 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP5PF protein_coding protein_coding 378.6739 548.0243 334.0523 41.63331 5.309415 -0.7141493 280.01875 418.79641 226.29245 34.189525 5.4812732 -0.88803136 0.72968750 0.76360000 0.67733333 -0.08626667 1.234305e-05 1.525127e-14 FALSE  
ENST00000400087 ENSG00000154723 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP5PF protein_coding protein_coding 378.6739 548.0243 334.0523 41.63331 5.309415 -0.7141493 30.42284 43.40790 30.25814 1.964676 2.1150097 -0.52049009 0.08331667 0.07983333 0.09056667 0.01073333 6.487464e-01 1.525127e-14 FALSE  
ENST00000400090 ENSG00000154723 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP5PF protein_coding protein_coding 378.6739 548.0243 334.0523 41.63331 5.309415 -0.7141493 26.26084 31.26545 32.20275 1.920449 0.9897228 0.04260154 0.07274583 0.05716667 0.09636667 0.03920000 1.525127e-14 1.525127e-14 FALSE  
ENST00000400093 ENSG00000154723 HEK293_OSMI2_2hA HEK293_TMG_2hB ATP5PF protein_coding protein_coding 378.6739 548.0243 334.0523 41.63331 5.309415 -0.7141493 18.63116 26.32550 18.62247 1.529558 0.3189976 -0.49919045 0.05072917 0.04816667 0.05576667 0.00760000 1.952449e-01 1.525127e-14 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000154723 E001 1.645901 1.022227e-01 2.850925e-02 6.903373e-02 21 25716503 25716560 58 - 0.661 0.231 -2.349
ENSG00000154723 E002 2.099302 6.889822e-03 4.993898e-03 1.591192e-02 21 25717661 25717759 99 - 0.739 0.289 -2.248
ENSG00000154723 E003 2.076408 3.341024e-02 8.383791e-01 8.989710e-01 21 25724480 25724494 15 - 0.446 0.493 0.233
ENSG00000154723 E004 2.921305 1.070072e-02 6.743365e-01 7.798351e-01 21 25724495 25724498 4 - 0.617 0.555 -0.276
ENSG00000154723 E005 7.726842 1.367200e-01 6.495831e-01 7.608331e-01 21 25724499 25724499 1 - 0.864 0.933 0.264
ENSG00000154723 E006 755.830423 5.632636e-04 9.506735e-09 1.177447e-07 21 25724500 25724616 117 - 2.770 2.877 0.357
ENSG00000154723 E007 1775.552637 8.008543e-04 8.077598e-04 3.286324e-03 21 25724617 25724677 61 - 3.177 3.231 0.181
ENSG00000154723 E008 10.324158 9.233915e-03 1.515360e-01 2.637605e-01 21 25724698 25725225 528 - 0.888 1.066 0.660
ENSG00000154723 E009 3449.130568 4.494721e-04 1.357006e-05 8.742162e-05 21 25725226 25725350 125 - 3.472 3.517 0.149
ENSG00000154723 E010 3928.011269 5.988158e-05 2.847054e-03 9.814862e-03 21 25729631 25729801 171 - 3.570 3.559 -0.038
ENSG00000154723 E011 123.181981 2.809305e-04 1.782295e-12 4.191812e-11 21 25734333 25734375 43 - 2.206 1.984 -0.744
ENSG00000154723 E012 40.712603 5.090987e-04 2.894634e-03 9.955334e-03 21 25734376 25734398 23 - 1.694 1.535 -0.541
ENSG00000154723 E013 1191.285599 8.035146e-04 1.549167e-01 2.683072e-01 21 25734853 25734938 86 - 3.057 3.035 -0.075
ENSG00000154723 E014 33.205558 1.526138e-03 1.727685e-02 4.555839e-02 21 25734939 25734988 50 - 1.602 1.460 -0.488
ENSG00000154723 E015 203.177022 1.968166e-04 7.463968e-03 2.242208e-02 21 25734989 25735030 42 - 2.321 2.258 -0.212
ENSG00000154723 E016 315.198053 1.600956e-04 9.392804e-03 2.726357e-02 21 25735031 25735314 284 - 2.502 2.454 -0.160
ENSG00000154723 E017 584.157261 3.990460e-03 1.552450e-02 4.168184e-02 21 25735315 25735486 172 - 2.788 2.704 -0.279
ENSG00000154723 E018 514.983638 4.578861e-03 5.129055e-05 2.882224e-04 21 25735487 25735673 187 - 2.774 2.626 -0.495