ENSG00000154529

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000377561 ENSG00000154529 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTNAP3B protein_coding protein_coding 1.453165 0.9006822 1.280658 0.2399454 0.250325 0.5030872 0.05455924 0.01323083 0.09269107 0.013230829 0.09269107 2.1441983 0.04216667 0.01273333 0.11880000 0.10606667 1.000000000 0.001321305 FALSE TRUE
ENST00000467854 ENSG00000154529 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTNAP3B protein_coding retained_intron 1.453165 0.9006822 1.280658 0.2399454 0.250325 0.5030872 0.15644399 0.00000000 0.14890285 0.000000000 0.06325942 3.9900731 0.09496250 0.00000000 0.10583333 0.10583333 0.012201513 0.001321305   FALSE
ENST00000476961 ENSG00000154529 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTNAP3B protein_coding protein_coding 1.453165 0.9006822 1.280658 0.2399454 0.250325 0.5030872 0.11477285 0.02876695 0.08472725 0.028766947 0.04353233 1.2889524 0.06595833 0.02770000 0.05543333 0.02773333 0.821002063 0.001321305 FALSE TRUE
ENST00000479351 ENSG00000154529 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTNAP3B protein_coding nonsense_mediated_decay 1.453165 0.9006822 1.280658 0.2399454 0.250325 0.5030872 0.35015604 0.41222571 0.17222655 0.087882321 0.03067561 -1.2122813 0.28738750 0.47750000 0.14486667 -0.33263333 0.001321305 0.001321305 TRUE TRUE
ENST00000480466 ENSG00000154529 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTNAP3B protein_coding processed_transcript 1.453165 0.9006822 1.280658 0.2399454 0.250325 0.5030872 0.06677955 0.00000000 0.09564337 0.000000000 0.05528878 3.4011303 0.04502083 0.00000000 0.06266667 0.06266667 0.206157014 0.001321305   FALSE
ENST00000484254 ENSG00000154529 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTNAP3B protein_coding retained_intron 1.453165 0.9006822 1.280658 0.2399454 0.250325 0.5030872 0.10514235 0.00000000 0.13163638 0.000000000 0.13163638 3.8241200 0.05766667 0.00000000 0.08523333 0.08523333 0.854771498 0.001321305   FALSE
ENST00000491438 ENSG00000154529 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTNAP3B protein_coding processed_transcript 1.453165 0.9006822 1.280658 0.2399454 0.250325 0.5030872 0.09948245 0.00000000 0.10581281 0.000000000 0.05290789 3.5337229 0.05750417 0.00000000 0.06913333 0.06913333 0.156497263 0.001321305   FALSE
ENST00000612828 ENSG00000154529 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTNAP3B protein_coding protein_coding 1.453165 0.9006822 1.280658 0.2399454 0.250325 0.5030872 0.16134035 0.06104478 0.14084532 0.045980105 0.07101610 1.0862693 0.10927500 0.06556667 0.09206667 0.02650000 0.899036929 0.001321305 FALSE TRUE
ENST00000617422 ENSG00000154529 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTNAP3B protein_coding protein_coding 1.453165 0.9006822 1.280658 0.2399454 0.250325 0.5030872 0.04610265 0.00000000 0.06460168 0.000000000 0.06460168 2.8992081 0.03795000 0.00000000 0.08280000 0.08280000 0.911639928 0.001321305 FALSE TRUE
ENST00000617848 ENSG00000154529 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTNAP3B protein_coding processed_transcript 1.453165 0.9006822 1.280658 0.2399454 0.250325 0.5030872 0.07480578 0.24973777 0.00000000 0.131431764 0.00000000 -4.6989839 0.05067500 0.21823333 0.00000000 -0.21823333 0.015882801 0.001321305   FALSE
ENST00000618777 ENSG00000154529 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTNAP3B protein_coding retained_intron 1.453165 0.9006822 1.280658 0.2399454 0.250325 0.5030872 0.06833238 0.01127701 0.10820683 0.001435015 0.05097302 2.4739459 0.04477500 0.01593333 0.09163333 0.07570000 0.114911049 0.001321305 FALSE TRUE
ENST00000619138 ENSG00000154529 HEK293_OSMI2_2hA HEK293_TMG_2hB CNTNAP3B protein_coding nonsense_mediated_decay 1.453165 0.9006822 1.280658 0.2399454 0.250325 0.5030872 0.07356177 0.09365733 0.06149252 0.013031611 0.06149252 -0.5359578 0.04967917 0.13833333 0.03983333 -0.09850000 0.448724225 0.001321305 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000154529 E001 0.0000000       9 41890314 41890535 222 -      
ENSG00000154529 E002 0.0000000       9 41890536 41891886 1351 -      
ENSG00000154529 E003 0.0000000       9 41891887 41893836 1950 -      
ENSG00000154529 E004 0.0000000       9 41893837 41894110 274 -      
ENSG00000154529 E005 0.0000000       9 41898462 41898471 10 -      
ENSG00000154529 E006 0.0000000       9 41898472 41898495 24 -      
ENSG00000154529 E007 0.0000000       9 41898496 41898533 38 -      
ENSG00000154529 E008 0.0000000       9 41898769 41898896 128 -      
ENSG00000154529 E009 0.0000000       9 41898897 41898999 103 -      
ENSG00000154529 E010 0.0000000       9 41899000 41899944 945 -      
ENSG00000154529 E011 0.0000000       9 41904890 41905097 208 -      
ENSG00000154529 E012 0.0000000       9 41905098 41905107 10 -      
ENSG00000154529 E013 0.0000000       9 41905108 41905867 760 -      
ENSG00000154529 E014 0.1482932 0.041106968 0.64506387   9 41905868 41905955 88 - 0.000 0.104 9.901
ENSG00000154529 E015 0.0000000       9 41905956 41906180 225 -      
ENSG00000154529 E016 0.2214452 0.041903612 0.64011433   9 41906181 41906279 99 - 0.000 0.104 12.148
ENSG00000154529 E017 0.4545463 0.804573677 0.24702734 0.38243515 9 41906280 41906853 574 - 0.340 0.000 -14.557
ENSG00000154529 E018 0.8942144 0.266729863 0.91667265 0.95134234 9 41906854 41906983 130 - 0.252 0.262 0.071
ENSG00000154529 E019 0.7426990 0.050724882 0.49554940 0.63233140 9 41906984 41906987 4 - 0.144 0.259 1.054
ENSG00000154529 E020 0.1515154 0.044977277 0.36193874   9 41908557 41908609 53 - 0.144 0.000 -13.726
ENSG00000154529 E021 1.0457299 0.463636695 0.90173356 0.94139761 9 41908610 41908781 172 - 0.339 0.263 -0.506
ENSG00000154529 E022 0.1472490 0.044235209 0.36248749   9 41920070 41920309 240 - 0.144 0.000 -13.726
ENSG00000154529 E023 1.5469113 0.101959689 0.48449788 0.62249065 9 41922677 41922895 219 - 0.471 0.322 -0.835
ENSG00000154529 E024 0.1482932 0.041106968 0.64506387   9 41923860 41923868 9 - 0.000 0.104 12.143
ENSG00000154529 E025 2.9923781 0.006078583 0.03249022 0.07678689 9 41923869 41923922 54 - 0.338 0.680 1.687
ENSG00000154529 E026 10.7972685 0.001703560 0.16038746 0.27565443 9 41923923 41924093 171 - 0.983 1.101 0.430
ENSG00000154529 E027 0.1817044 0.042738656 0.64071809   9 41926656 41926778 123 - 0.000 0.104 12.145
ENSG00000154529 E028 5.8194266 0.003032358 0.09734181 0.18641810 9 41929317 41929444 128 - 0.692 0.889 0.785
ENSG00000154529 E029 0.0000000       9 41938060 41938062 3 -      
ENSG00000154529 E030 0.1482932 0.041106968 0.64506387   9 41938063 41938243 181 - 0.000 0.104 12.143
ENSG00000154529 E031 2.2077497 0.008848178 0.31677201 0.45956600 9 41938244 41938400 157 - 0.409 0.568 0.782
ENSG00000154529 E032 2.0218806 0.009537786 0.73640016 0.82689672 9 41953183 41953383 201 - 0.525 0.461 -0.316
ENSG00000154529 E033 0.1451727 0.044013878 0.36310124   9 41953384 41953386 3 - 0.144 0.000 -13.726
ENSG00000154529 E034 0.1515154 0.044977277 0.36193874   9 41960003 41960320 318 - 0.144 0.000 -13.726
ENSG00000154529 E035 1.3586764 0.012589386 0.40047128 0.54416930 9 41960773 41960892 120 - 0.471 0.318 -0.861
ENSG00000154529 E036 0.0000000       9 41964538 41964644 107 -      
ENSG00000154529 E037 0.1472490 0.044235209 0.36248749   9 41970074 41970245 172 - 0.144 0.000 -13.726
ENSG00000154529 E038 3.5257403 0.006378899 0.61228004 0.73124132 9 41986168 41986311 144 - 0.616 0.679 0.269
ENSG00000154529 E039 4.4522225 0.005163978 0.59994647 0.72127211 9 41991610 41991871 262 - 0.785 0.703 -0.331
ENSG00000154529 E040 0.2934659 0.028669007 0.80637408   9 41993027 41994779 1753 - 0.144 0.104 -0.538
ENSG00000154529 E041 6.0766817 0.003230600 0.03686412 0.08520877 9 41996205 41996348 144 - 0.983 0.726 -0.996
ENSG00000154529 E042 6.8246913 0.003828775 0.14699656 0.25759399 9 41997568 41997752 185 - 0.983 0.806 -0.674
ENSG00000154529 E043 2.6412917 0.007207606 0.87202932 0.92170846 9 41998401 41998604 204 - 0.573 0.536 -0.173
ENSG00000154529 E044 0.0000000       9 42013378 42013525 148 -      
ENSG00000154529 E045 0.0000000       9 42076869 42077062 194 -      
ENSG00000154529 E046 0.2998086 0.028752734 0.80463728   9 42104629 42104739 111 - 0.144 0.104 -0.539
ENSG00000154529 E047 2.1787052 0.007273408 0.41672202 0.56010646 9 42129010 42129510 501 - 0.410 0.535 0.633