ENSG00000154380

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358675 ENSG00000154380 HEK293_OSMI2_2hA HEK293_TMG_2hB ENAH protein_coding retained_intron 62.56684 28.84168 101.6869 1.465165 1.664477 1.817549 17.552246 9.096873 28.272464 0.3306635 1.3671753 1.6348802 0.2839292 0.3159000 0.27776667 -0.03813333 2.618549e-01 8.605947e-73 FALSE TRUE
ENST00000366843 ENSG00000154380 HEK293_OSMI2_2hA HEK293_TMG_2hB ENAH protein_coding protein_coding 62.56684 28.84168 101.6869 1.465165 1.664477 1.817549 5.242875 4.658870 7.154901 0.5803489 0.3043803 0.6178733 0.1091958 0.1645667 0.07036667 -0.09420000 3.421419e-03 8.605947e-73 FALSE TRUE
ENST00000391874 ENSG00000154380 HEK293_OSMI2_2hA HEK293_TMG_2hB ENAH protein_coding processed_transcript 62.56684 28.84168 101.6869 1.465165 1.664477 1.817549 9.660278 0.000000 22.819113 0.0000000 0.4358905 11.1566591 0.1369917 0.0000000 0.22460000 0.22460000 8.605947e-73 8.605947e-73 FALSE FALSE
ENST00000497899 ENSG00000154380 HEK293_OSMI2_2hA HEK293_TMG_2hB ENAH protein_coding protein_coding 62.56684 28.84168 101.6869 1.465165 1.664477 1.817549 5.707255 7.979506 4.037380 0.8134194 1.9052188 -0.9811181 0.1296458 0.2753000 0.03943333 -0.23586667 2.571752e-02 8.605947e-73 FALSE TRUE
ENST00000635051 ENSG00000154380 HEK293_OSMI2_2hA HEK293_TMG_2hB ENAH protein_coding protein_coding 62.56684 28.84168 101.6869 1.465165 1.664477 1.817549 5.935342 2.039892 10.119417 0.1487655 0.3155327 2.3049315 0.0900375 0.0706000 0.09956667 0.02896667 2.607367e-02 8.605947e-73 FALSE TRUE
MSTRG.3141.11 ENSG00000154380 HEK293_OSMI2_2hA HEK293_TMG_2hB ENAH protein_coding   62.56684 28.84168 101.6869 1.465165 1.664477 1.817549 12.388059 3.812093 17.606641 0.9892542 0.7495783 2.2045039 0.1664167 0.1299000 0.17333333 0.04343333 5.048153e-01 8.605947e-73 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000154380 E001 0.0000000       1 225486765 225486828 64 -      
ENSG00000154380 E002 0.0000000       1 225486829 225486834 6 -      
ENSG00000154380 E003 1231.0191547 0.0141232085 1.638057e-08 1.940745e-07 1 225486835 225495479 8645 - 2.910 3.271 1.200
ENSG00000154380 E004 1390.1550194 0.0009893071 8.248609e-11 1.476310e-09 1 225495480 225496884 1405 - 3.048 3.214 0.553
ENSG00000154380 E005 757.3741995 0.0006920949 1.383643e-02 3.785392e-02 1 225496885 225497422 538 - 2.835 2.853 0.059
ENSG00000154380 E006 401.9078281 0.0001297961 3.430386e-04 1.552240e-03 1 225497423 225497633 211 - 2.569 2.562 -0.023
ENSG00000154380 E007 423.6705636 0.0001216717 1.854156e-10 3.123460e-09 1 225497634 225497812 179 - 2.606 2.545 -0.202
ENSG00000154380 E008 301.8902886 0.0001679231 2.116426e-15 7.660500e-14 1 225498347 225498404 58 - 2.475 2.350 -0.417
ENSG00000154380 E009 346.1516108 0.0025269650 7.814766e-09 9.823396e-08 1 225500992 225501070 79 - 2.534 2.407 -0.423
ENSG00000154380 E010 0.8189741 0.0312816378 6.738955e-01 7.794679e-01 1 225501071 225501256 186 - 0.247 0.192 -0.467
ENSG00000154380 E011 14.6445234 0.0012073116 5.014340e-04 2.165266e-03 1 225504991 225505053 63 - 1.016 1.384 1.307
ENSG00000154380 E012 327.0987108 0.0001676633 1.327753e-12 3.191712e-11 1 225507951 225508017 67 - 2.503 2.405 -0.324
ENSG00000154380 E013 0.0000000       1 225508389 225508583 195 -      
ENSG00000154380 E014 266.5454488 0.0002338921 5.467689e-05 3.050888e-04 1 225511811 225511859 49 - 2.399 2.363 -0.122
ENSG00000154380 E015 286.1304321 0.0001730673 8.264792e-05 4.405323e-04 1 225512657 225512714 58 - 2.426 2.397 -0.099
ENSG00000154380 E016 326.4925763 0.0012027618 2.105521e-04 1.009042e-03 1 225512871 225513016 146 - 2.486 2.447 -0.129
ENSG00000154380 E017 240.6226534 0.0026507644 6.085539e-01 7.282649e-01 1 225514596 225514900 305 - 2.330 2.373 0.145
ENSG00000154380 E018 4.2511444 0.0037905014 3.909071e-01 5.348522e-01 1 225514901 225515397 497 - 0.717 0.635 -0.345
ENSG00000154380 E019 151.8325376 0.0024982462 2.083777e-01 3.365261e-01 1 225517196 225517306 111 - 2.109 2.220 0.368
ENSG00000154380 E020 103.3019054 0.0003033723 4.354909e-01 5.777321e-01 1 225517307 225517990 684 - 1.969 2.002 0.112
ENSG00000154380 E021 11.3651707 0.0017010993 6.143285e-11 1.121113e-09 1 225519044 225519197 154 - 0.717 1.422 2.594
ENSG00000154380 E022 415.7953951 0.0026680237 4.425872e-01 5.841844e-01 1 225519198 225519417 220 - 2.554 2.638 0.281
ENSG00000154380 E023 398.4646824 0.0009290860 1.569315e-04 7.780739e-04 1 225519418 225519565 148 - 2.570 2.540 -0.098
ENSG00000154380 E024 0.0000000       1 225524599 225524689 91 -      
ENSG00000154380 E025 324.1601154 0.0029552502 2.148281e-05 1.322068e-04 1 225530554 225530638 85 - 2.495 2.409 -0.284
ENSG00000154380 E026 0.2924217 0.0271610599 5.947028e-01   1 225531046 225531057 12 - 0.141 0.000 -9.998
ENSG00000154380 E027 8.8797037 0.0019227674 1.988717e-01 3.247928e-01 1 225535507 225535563 57 - 0.983 0.883 -0.377
ENSG00000154380 E028 407.6474820 0.0103896579 1.783397e-02 4.678193e-02 1 225554906 225555083 178 - 2.588 2.525 -0.209
ENSG00000154380 E029 326.4052322 0.0110818756 5.641742e-03 1.766221e-02 1 225567249 225567414 166 - 2.500 2.407 -0.309
ENSG00000154380 E030 0.8189741 0.0312816378 6.738955e-01 7.794679e-01 1 225577853 225577936 84 - 0.247 0.192 -0.467
ENSG00000154380 E031 0.0000000       1 225580167 225580257 91 -      
ENSG00000154380 E032 3.3925156 0.0046645349 8.890315e-01 9.330317e-01 1 225595208 225595325 118 - 0.609 0.635 0.115
ENSG00000154380 E033 13.9319215 0.0012111966 9.653300e-06 6.441211e-05 1 225600208 225600362 155 - 1.233 0.776 -1.693
ENSG00000154380 E034 0.1817044 0.0411470785 1.906167e-01   1 225600363 225600364 2 - 0.000 0.191 11.781
ENSG00000154380 E035 4.4672911 0.0035371038 9.010076e-01 9.408538e-01 1 225652318 225652433 116 - 0.701 0.734 0.137
ENSG00000154380 E036 216.6361486 0.0061000132 9.928755e-07 8.242289e-06 1 225652686 225653142 457 - 2.342 2.169 -0.577