ENSG00000154370

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000284551 ENSG00000154370 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM11 protein_coding protein_coding 56.74491 102.7447 30.83777 6.842636 0.3336358 -1.735966 43.964920 85.717372 22.152742 5.3483778 0.57046649 -1.951620 0.7488333 0.83480000 0.71820000 -0.11660000 1.763775e-07 1.763775e-07 FALSE TRUE
ENST00000366699 ENSG00000154370 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM11 protein_coding protein_coding 56.74491 102.7447 30.83777 6.842636 0.3336358 -1.735966 4.232743 5.860880 2.450774 0.5295341 0.22216089 -1.254465 0.0836125 0.05686667 0.07963333 0.02276667 1.391925e-01 1.763775e-07 FALSE TRUE
ENST00000475775 ENSG00000154370 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM11 protein_coding processed_transcript 56.74491 102.7447 30.83777 6.842636 0.3336358 -1.735966 4.636080 6.092334 2.913310 0.2047204 0.09837634 -1.061758 0.0861375 0.05956667 0.09446667 0.03490000 1.118024e-03 1.763775e-07 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000154370 E001 4.715582 0.0043138415 5.272549e-01 6.603697e-01 1 228393673 228393675 3 - 0.726 0.647 -0.334
ENSG00000154370 E002 2792.437758 0.0045087806 2.055860e-06 1.594777e-05 1 228393676 228394824 1149 - 3.224 3.360 0.451
ENSG00000154370 E003 1145.354255 0.0005417262 3.795331e-04 1.695468e-03 1 228394825 228395207 383 - 2.877 2.962 0.282
ENSG00000154370 E004 369.366470 0.0002488495 2.714141e-01 4.101741e-01 1 228395208 228395252 45 - 2.454 2.453 -0.002
ENSG00000154370 E005 229.402831 0.0005207805 1.921771e-02 4.980898e-02 1 228395534 228396612 1079 - 2.286 2.241 -0.150
ENSG00000154370 E006 75.796807 0.0036676789 2.874259e-03 9.895322e-03 1 228396613 228396946 334 - 1.883 1.745 -0.465
ENSG00000154370 E007 423.366773 0.0003339766 1.494089e-01 2.608546e-01 1 228396947 228397047 101 - 2.519 2.512 -0.022
ENSG00000154370 E008 19.317891 0.0010180245 8.294661e-01 8.929257e-01 1 228397048 228397142 95 - 1.199 1.202 0.009
ENSG00000154370 E009 227.651197 0.0033274693 3.725257e-01 5.169717e-01 1 228397143 228397165 23 - 2.193 2.259 0.219
ENSG00000154370 E010 122.435769 0.0002905941 2.847103e-04 1.317735e-03 1 228397166 228397689 524 - 2.071 1.958 -0.380
ENSG00000154370 E011 481.907271 0.0029657694 9.072462e-01 9.450936e-01 1 228400964 228401194 231 - 2.545 2.579 0.114
ENSG00000154370 E012 312.255281 0.0029379549 2.625632e-06 1.991425e-05 1 228402066 228402161 96 - 2.489 2.357 -0.439
ENSG00000154370 E013 185.087456 0.0061134108 1.125543e-15 4.220101e-14 1 228402162 228405904 3743 - 2.416 2.072 -1.150
ENSG00000154370 E014 562.904582 0.0126367227 1.483810e-04 7.399265e-04 1 228406154 228406835 682 - 2.771 2.606 -0.548