ENSG00000154310

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341852 ENSG00000154310 HEK293_OSMI2_2hA HEK293_TMG_2hB TNIK protein_coding protein_coding 5.623921 5.623182 7.433754 0.8078093 0.1129064 0.4020804 0.9615630 0.1525271 2.0374090 0.1525271 0.09375214 3.6550473 0.15636667 0.03066667 0.27456667 0.24390000 3.583746e-02 3.36882e-17 FALSE TRUE
ENST00000436636 ENSG00000154310 HEK293_OSMI2_2hA HEK293_TMG_2hB TNIK protein_coding protein_coding 5.623921 5.623182 7.433754 0.8078093 0.1129064 0.4020804 2.1076336 2.4345107 2.6668745 0.1342805 0.06007245 0.1310037 0.37582917 0.44443333 0.35906667 -0.08536667 4.043536e-01 3.36882e-17 FALSE TRUE
ENST00000465393 ENSG00000154310 HEK293_OSMI2_2hA HEK293_TMG_2hB TNIK protein_coding protein_coding 5.623921 5.623182 7.433754 0.8078093 0.1129064 0.4020804 1.0868751 2.3068644 0.6444517 0.2327551 0.12239997 -1.8238150 0.20280000 0.41506667 0.08683333 -0.32823333 3.189863e-10 3.36882e-17   FALSE
ENST00000470834 ENSG00000154310 HEK293_OSMI2_2hA HEK293_TMG_2hB TNIK protein_coding protein_coding 5.623921 5.623182 7.433754 0.8078093 0.1129064 0.4020804 0.8153014 0.0000000 2.0850194 0.0000000 0.28054113 7.7108198 0.13172917 0.00000000 0.27946667 0.27946667 3.368820e-17 3.36882e-17 FALSE TRUE
ENST00000475336 ENSG00000154310 HEK293_OSMI2_2hA HEK293_TMG_2hB TNIK protein_coding protein_coding 5.623921 5.623182 7.433754 0.8078093 0.1129064 0.4020804 0.2206364 0.4470179 0.0000000 0.2699134 0.00000000 -5.5141787 0.04389167 0.07083333 0.00000000 -0.07083333 1.524543e-03 3.36882e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000154310 E001 372.9823291 0.0090526437 2.278926e-11 4.479273e-10 3 171058414 171063260 4847 - 2.402 2.728 1.086
ENSG00000154310 E002 32.5241239 0.0006418317 1.493996e-03 5.616516e-03 3 171063261 171063329 69 - 1.402 1.646 0.837
ENSG00000154310 E003 48.4471961 0.0005143266 1.841512e-04 8.956378e-04 3 171063330 171063483 154 - 1.572 1.812 0.813
ENSG00000154310 E004 29.4433209 0.0048367632 1.010522e-03 3.994833e-03 3 171063484 171063550 67 - 1.338 1.620 0.972
ENSG00000154310 E005 18.8821434 0.0313282184 1.192933e-01 2.189327e-01 3 171063551 171063551 1 - 1.186 1.407 0.774
ENSG00000154310 E006 43.2024915 0.0036443101 3.908792e-02 8.935252e-02 3 171063552 171063628 77 - 1.554 1.728 0.589
ENSG00000154310 E007 37.6956383 0.0005462561 5.406521e-01 6.717577e-01 3 171063629 171063682 54 - 1.542 1.629 0.296
ENSG00000154310 E008 53.6521765 0.0030842968 9.501883e-01 9.728292e-01 3 171063683 171063880 198 - 1.709 1.766 0.191
ENSG00000154310 E009 29.1168496 0.0007810924 4.468784e-01 5.883359e-01 3 171063881 171063964 84 - 1.431 1.531 0.346
ENSG00000154310 E010 0.5943067 0.0200447330 5.504131e-01 6.800572e-01 3 171063965 171064042 78 - 0.241 0.155 -0.793
ENSG00000154310 E011 46.5426531 0.0020619310 5.481094e-01 6.779998e-01 3 171066187 171066326 140 - 1.665 1.686 0.071
ENSG00000154310 E012 0.5911862 0.0183141908 9.226551e-02 1.786678e-01 3 171066374 171066469 96 - 0.299 0.000 -13.205
ENSG00000154310 E013 0.1472490 0.0428497432 7.247063e-01   3 171066470 171066486 17 - 0.096 0.000 -11.170
ENSG00000154310 E014 0.1472490 0.0428497432 7.247063e-01   3 171066487 171066575 89 - 0.096 0.000 -11.170
ENSG00000154310 E015 53.4841119 0.0112088000 9.615547e-01 9.797748e-01 3 171066576 171066735 160 - 1.705 1.768 0.211
ENSG00000154310 E016 48.7741141 0.0011792989 2.682401e-01 4.066814e-01 3 171068848 171068987 140 - 1.644 1.753 0.373
ENSG00000154310 E017 18.4214512 0.0068208253 4.967609e-01 6.333581e-01 3 171068988 171068997 10 - 1.232 1.342 0.386
ENSG00000154310 E018 35.3508708 0.0025292588 7.309295e-01 8.226930e-01 3 171071223 171071323 101 - 1.539 1.569 0.100
ENSG00000154310 E019 0.0000000       3 171071324 171071406 83 -      
ENSG00000154310 E020 38.9542586 0.0099629424 5.913420e-01 7.141317e-01 3 171079518 171079652 135 - 1.586 1.596 0.035
ENSG00000154310 E021 47.5725180 0.0021229055 5.047333e-02 1.100069e-01 3 171082251 171082394 144 - 1.698 1.643 -0.190
ENSG00000154310 E022 0.1451727 0.0427158456 7.245850e-01   3 171082395 171082682 288 - 0.096 0.000 -11.170
ENSG00000154310 E023 49.5409285 0.0018240337 7.760461e-02 1.556158e-01 3 171084155 171084325 171 - 1.713 1.671 -0.144
ENSG00000154310 E024 40.5752410 0.0005302106 6.048323e-02 1.274412e-01 3 171085118 171085229 112 - 1.631 1.578 -0.181
ENSG00000154310 E025 38.6515914 0.0028094967 1.128193e-01 2.096550e-01 3 171087342 171087506 165 - 1.608 1.563 -0.152
ENSG00000154310 E026 39.3349196 0.0020643230 4.141096e-02 9.364474e-02 3 171093839 171093968 130 - 1.624 1.553 -0.240
ENSG00000154310 E027 47.2275878 0.0080670437 4.431951e-03 1.434978e-02 3 171101449 171101633 185 - 1.729 1.588 -0.478
ENSG00000154310 E028 0.1451727 0.0427158456 7.245850e-01   3 171101634 171102072 439 - 0.096 0.000 -11.170
ENSG00000154310 E029 9.6769790 0.0068380568 1.688631e-02 4.468086e-02 3 171107183 171107206 24 - 1.101 0.871 -0.852
ENSG00000154310 E030 34.2343184 0.0072036808 4.440224e-03 1.437239e-02 3 171108065 171108162 98 - 1.600 1.440 -0.545
ENSG00000154310 E031 38.1409576 0.0005735728 3.746465e-05 2.174766e-04 3 171110714 171110877 164 - 1.653 1.460 -0.659
ENSG00000154310 E032 32.0886106 0.0008127743 1.509464e-04 7.512700e-04 3 171123596 171123702 107 - 1.578 1.383 -0.670
ENSG00000154310 E033 42.8317685 0.0005339631 2.221623e-05 1.362997e-04 3 171125912 171126151 240 - 1.701 1.515 -0.633
ENSG00000154310 E034 20.7509580 0.0116484794 5.800625e-04 2.460175e-03 3 171128714 171128878 165 - 1.423 1.143 -0.982
ENSG00000154310 E035 26.7646628 0.0055067789 8.295815e-03 2.453275e-02 3 171138191 171138379 189 - 1.490 1.335 -0.536
ENSG00000154310 E036 0.4375944 0.0260933645 1.748029e-01 2.944498e-01 3 171139470 171139556 87 - 0.241 0.000 -12.778
ENSG00000154310 E037 18.9015336 0.0227400269 1.482481e-01 2.592963e-01 3 171140399 171140509 111 - 1.332 1.218 -0.400
ENSG00000154310 E038 21.3535433 0.0008519759 6.871631e-04 2.852469e-03 3 171157460 171157550 91 - 1.418 1.204 -0.749
ENSG00000154310 E039 25.3613570 0.0060063862 2.917968e-03 1.002467e-02 3 171157551 171157664 114 - 1.483 1.298 -0.642
ENSG00000154310 E040 27.1267353 0.0007384059 7.673360e-05 4.126065e-04 3 171161270 171161336 67 - 1.523 1.298 -0.781
ENSG00000154310 E041 38.8617015 0.0005313422 1.076216e-05 7.098844e-05 3 171167095 171167270 176 - 1.667 1.460 -0.707
ENSG00000154310 E042 26.0108974 0.0029405451 1.538408e-05 9.792908e-05 3 171175252 171175330 79 - 1.517 1.238 -0.968
ENSG00000154310 E043 20.4447823 0.0091837653 2.441800e-04 1.150869e-03 3 171177326 171177380 55 - 1.418 1.129 -1.015
ENSG00000154310 E044 30.8510419 0.0020809541 1.048151e-03 4.125938e-03 3 171188702 171188832 131 - 1.554 1.383 -0.589
ENSG00000154310 E045 24.9423950 0.0117367888 1.478216e-01 2.587185e-01 3 171190697 171190787 91 - 1.435 1.367 -0.235
ENSG00000154310 E046 33.1677649 0.0007868416 3.451404e-03 1.158604e-02 3 171194525 171194635 111 - 1.578 1.447 -0.448
ENSG00000154310 E047 32.7485938 0.0007473439 2.949604e-03 1.011611e-02 3 171211116 171211241 126 - 1.575 1.440 -0.462
ENSG00000154310 E048 0.0000000       3 171225534 171225711 178 -      
ENSG00000154310 E049 19.0818007 0.0010040363 4.786085e-04 2.078119e-03 3 171228165 171228221 57 - 1.380 1.142 -0.839
ENSG00000154310 E050 17.4772620 0.0011351447 6.708235e-18 3.354950e-16 3 171346934 171347218 285 - 0.736 1.558 2.982
ENSG00000154310 E051 35.3076297 0.0006179477 4.169708e-01 5.603643e-01 3 171369620 171369685 66 - 1.507 1.607 0.340
ENSG00000154310 E052 48.1412139 0.0005021784 6.929940e-01 7.941015e-01 3 171460007 171460408 402 - 1.651 1.723 0.245