ENSG00000154305

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000340535 ENSG00000154305 HEK293_OSMI2_2hA HEK293_TMG_2hB MIA3 protein_coding protein_coding 25.13515 11.84194 26.9858 3.046006 0.4107382 1.187611 2.453308 4.6010915 0.6499605 0.6243253 0.14285483 -2.804657 0.16467917 0.46043333 0.02400000 -0.43643333 3.070943e-05 2.566332e-24 FALSE TRUE
ENST00000344922 ENSG00000154305 HEK293_OSMI2_2hA HEK293_TMG_2hB MIA3 protein_coding protein_coding 25.13515 11.84194 26.9858 3.046006 0.4107382 1.187611 6.944375 1.0045625 10.6370742 0.2772342 0.36718876 3.391527 0.22071250 0.08350000 0.39460000 0.31110000 2.566332e-24 2.566332e-24 FALSE TRUE
ENST00000354906 ENSG00000154305 HEK293_OSMI2_2hA HEK293_TMG_2hB MIA3 protein_coding protein_coding 25.13515 11.84194 26.9858 3.046006 0.4107382 1.187611 2.336586 0.0000000 3.4871637 0.0000000 0.55349877 8.450042 0.06572917 0.00000000 0.12910000 0.12910000 2.039750e-14 2.566332e-24 FALSE TRUE
ENST00000476400 ENSG00000154305 HEK293_OSMI2_2hA HEK293_TMG_2hB MIA3 protein_coding processed_transcript 25.13515 11.84194 26.9858 3.046006 0.4107382 1.187611 3.222523 3.7922701 0.5621052 1.9000348 0.03390025 -2.732509 0.18645833 0.25793333 0.02083333 -0.23710000 4.661972e-01 2.566332e-24 FALSE FALSE
ENST00000479370 ENSG00000154305 HEK293_OSMI2_2hA HEK293_TMG_2hB MIA3 protein_coding processed_transcript 25.13515 11.84194 26.9858 3.046006 0.4107382 1.187611 1.172177 0.3453805 1.4130202 0.1125634 0.12144373 2.001520 0.05021667 0.02753333 0.05250000 0.02496667 1.006594e-01 2.566332e-24   FALSE
MSTRG.3099.10 ENSG00000154305 HEK293_OSMI2_2hA HEK293_TMG_2hB MIA3 protein_coding   25.13515 11.84194 26.9858 3.046006 0.4107382 1.187611 4.666441 0.5207071 6.1545282 0.5207071 0.44978851 3.538003 0.13800417 0.03793333 0.22850000 0.19056667 7.888702e-02 2.566332e-24 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000154305 E001 0.1451727 0.0433914549 1.000000e+00   1 222618087 222618087 1 + 0.076 0.000 -7.891
ENSG00000154305 E002 1.0611596 0.0577459850 4.683450e-01 6.077578e-01 1 222618088 222618096 9 + 0.330 0.193 -1.029
ENSG00000154305 E003 1.0611596 0.0577459850 4.683450e-01 6.077578e-01 1 222618097 222618098 2 + 0.330 0.193 -1.029
ENSG00000154305 E004 26.7540230 0.0011524703 1.915105e-13 5.236123e-12 1 222618099 222618243 145 + 1.520 0.780 -2.677
ENSG00000154305 E005 48.3470164 0.0004632093 1.865350e-24 1.936356e-22 1 222621159 222621292 134 + 1.773 0.971 -2.802
ENSG00000154305 E006 2.6742320 0.0056149276 1.821572e-03 6.668817e-03 1 222623307 222623351 45 + 0.645 0.000 -14.651
ENSG00000154305 E007 34.3661674 0.0011417069 3.279009e-17 1.496143e-15 1 222624768 222624809 42 + 1.628 0.853 -2.755
ENSG00000154305 E008 38.0681609 0.0127404698 1.486064e-13 4.122571e-12 1 222624810 222624854 45 + 1.672 0.887 -2.778
ENSG00000154305 E009 215.8295641 0.0781237298 6.763868e-09 8.609208e-08 1 222627575 222628473 899 + 2.415 1.645 -2.587
ENSG00000154305 E010 428.2958966 0.0002019251 6.343527e-121 3.338228e-117 1 222628474 222630306 1833 + 2.692 2.147 -1.817
ENSG00000154305 E011 59.1783536 0.0003987214 1.838076e-09 2.592859e-08 1 222630307 222630389 83 + 1.812 1.485 -1.111
ENSG00000154305 E012 71.6547995 0.0003687165 3.129243e-14 9.574059e-13 1 222632165 222632326 162 + 1.901 1.508 -1.332
ENSG00000154305 E013 56.7077890 0.0083896148 3.630236e-08 4.021150e-07 1 222633104 222633249 146 + 1.803 1.400 -1.375
ENSG00000154305 E014 1.6607648 0.0082734660 1.543309e-01 2.675372e-01 1 222644303 222644325 23 + 0.462 0.192 -1.768
ENSG00000154305 E015 1.8080138 0.0075252691 1.175286e-01 2.164089e-01 1 222644326 222644327 2 + 0.490 0.192 -1.906
ENSG00000154305 E016 5.6444651 0.0030176467 5.765425e-01 7.019462e-01 1 222644328 222644344 17 + 0.801 0.737 -0.253
ENSG00000154305 E017 11.2735957 0.0014644970 3.110837e-03 1.059254e-02 1 222644345 222644393 49 + 1.125 0.779 -1.299
ENSG00000154305 E018 25.0725098 0.0007880563 3.538193e-06 2.606752e-05 1 222644394 222644586 193 + 1.458 1.064 -1.388
ENSG00000154305 E019 33.9175673 0.0162193405 4.859002e-05 2.746355e-04 1 222645554 222645557 4 + 1.584 1.192 -1.359
ENSG00000154305 E020 82.3828510 0.0032354621 1.152041e-14 3.753357e-13 1 222645558 222645685 128 + 1.968 1.531 -1.480
ENSG00000154305 E021 2.0262368 0.0071337725 7.916658e-01 8.667463e-01 1 222645686 222646135 450 + 0.462 0.427 -0.183
ENSG00000154305 E022 52.0859401 0.0004220421 1.146096e-10 2.002993e-09 1 222648829 222648850 22 + 1.765 1.378 -1.323
ENSG00000154305 E023 2.4076311 0.0060264664 4.820425e-01 6.202010e-01 1 222649263 222649791 529 + 0.540 0.427 -0.563
ENSG00000154305 E024 90.7541980 0.0003166634 1.810435e-19 1.089868e-17 1 222650292 222650380 89 + 2.007 1.584 -1.430
ENSG00000154305 E025 88.8225017 0.0003148307 6.219409e-18 3.125327e-16 1 222650634 222650711 78 + 1.995 1.590 -1.367
ENSG00000154305 E026 101.7405036 0.0002742129 8.221953e-22 6.404706e-20 1 222650793 222650903 111 + 2.057 1.632 -1.434
ENSG00000154305 E027 86.0234374 0.0003244419 4.999648e-17 2.226013e-15 1 222651977 222652048 72 + 1.981 1.584 -1.343
ENSG00000154305 E028 95.5630546 0.0004389619 1.540268e-13 4.262331e-12 1 222652228 222652332 105 + 2.014 1.695 -1.078
ENSG00000154305 E029 108.4597570 0.0007568862 4.846383e-15 1.670243e-13 1 222653008 222653130 123 + 2.070 1.741 -1.105
ENSG00000154305 E030 103.5600993 0.0025209361 1.321306e-13 3.694178e-12 1 222653228 222653339 112 + 2.056 1.700 -1.201
ENSG00000154305 E031 100.3770544 0.0002974707 1.724124e-12 4.061048e-11 1 222654243 222654298 56 + 2.031 1.741 -0.976
ENSG00000154305 E032 131.5719214 0.0005913895 5.901736e-02 1.249515e-01 1 222654389 222654479 91 + 2.050 2.136 0.288
ENSG00000154305 E033 198.0412706 0.0004629639 1.781093e-10 3.010015e-09 1 222654655 222654793 139 + 2.185 2.382 0.659
ENSG00000154305 E034 1.0706228 0.0118307904 8.936205e-01 9.359501e-01 1 222658642 222658721 80 + 0.290 0.325 0.231
ENSG00000154305 E035 174.6300058 0.0002262344 2.538698e-26 3.108168e-24 1 222658722 222658823 102 + 2.079 2.395 1.056
ENSG00000154305 E036 137.2333118 0.0002574695 3.889013e-25 4.306031e-23 1 222659453 222659513 61 + 1.962 2.306 1.153
ENSG00000154305 E037 90.5627038 0.0037500273 4.404994e-14 1.316682e-12 1 222659622 222659657 36 + 1.766 2.147 1.281
ENSG00000154305 E038 107.7418301 0.0003662056 7.983014e-19 4.463867e-17 1 222659734 222659801 68 + 1.863 2.198 1.123
ENSG00000154305 E039 77.1214669 0.0003597587 2.163030e-17 1.010554e-15 1 222659906 222659938 33 + 1.701 2.073 1.252
ENSG00000154305 E040 105.2890764 0.0003083401 4.369843e-30 7.438038e-28 1 222659939 222660006 68 + 1.808 2.232 1.423
ENSG00000154305 E041 139.7448747 0.0002511546 3.272688e-34 7.597725e-32 1 222660177 222660314 138 + 1.946 2.342 1.323
ENSG00000154305 E042 101.9129724 0.0002723226 9.990480e-17 4.297608e-15 1 222662056 222662082 27 + 1.847 2.168 1.076
ENSG00000154305 E043 76.7059164 0.0006567191 4.891214e-09 6.394933e-08 1 222662083 222662089 7 + 1.750 2.020 0.908
ENSG00000154305 E044 105.1687043 0.0016336873 7.472484e-12 1.587752e-10 1 222662090 222662124 35 + 1.876 2.168 0.981
ENSG00000154305 E045 136.9599841 0.0016063611 9.037345e-15 2.992655e-13 1 222662253 222662332 80 + 1.985 2.284 1.001
ENSG00000154305 E046 7.8328239 0.0021315568 7.232805e-01 8.171423e-01 1 222662333 222662457 125 + 0.884 0.945 0.232
ENSG00000154305 E047 21.0055568 0.0008776604 1.817424e-02 4.750792e-02 1 222662458 222662887 430 + 1.348 1.158 -0.669
ENSG00000154305 E048 17.9346017 0.0532656407 8.835173e-01 9.294896e-01 1 222662888 222663031 144 + 1.231 1.250 0.070
ENSG00000154305 E049 32.0188590 0.0011813087 2.285907e-01 3.607526e-01 1 222663032 222663970 939 + 1.492 1.426 -0.226
ENSG00000154305 E050 6.3870493 0.0026572982 3.899073e-01 5.339510e-01 1 222663971 222663997 27 + 0.787 0.916 0.499
ENSG00000154305 E051 169.3468101 0.0075802289 6.570120e-09 8.381748e-08 1 222663998 222664148 151 + 2.072 2.384 1.042
ENSG00000154305 E052 3.0740576 0.0048149177 8.956894e-01 9.373553e-01 1 222664149 222664654 506 + 0.585 0.578 -0.032
ENSG00000154305 E053 3.5302948 0.0061731188 1.876484e-03 6.842219e-03 1 222664883 222665308 426 + 0.401 0.887 2.142
ENSG00000154305 E054 510.8457301 0.0086936201 1.547379e-14 4.964373e-13 1 222665309 222668007 2699 + 2.528 2.888 1.197