ENSG00000154222

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000284376 ENSG00000154222 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D1B protein_coding protein_coding 24.51361 29.79306 14.93449 2.463819 1.019027 -0.9958465 3.339977 4.963978 2.2614372 0.3580714 0.2371949 -1.1307948 0.13623750 0.16730000 0.15413333 -0.013166667 8.556201e-01 5.4107e-11 FALSE TRUE
ENST00000438021 ENSG00000154222 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D1B protein_coding protein_coding 24.51361 29.79306 14.93449 2.463819 1.019027 -0.9958465 1.726091 4.524344 0.0000000 1.1854989 0.0000000 -8.8247500 0.05493750 0.15390000 0.00000000 -0.153900000 5.410700e-11 5.4107e-11 FALSE TRUE
ENST00000460261 ENSG00000154222 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D1B protein_coding processed_transcript 24.51361 29.79306 14.93449 2.463819 1.019027 -0.9958465 1.259530 1.146342 0.7229014 0.2416374 0.1717232 -0.6578765 0.05229583 0.03796667 0.04743333 0.009466667 7.391731e-01 5.4107e-11 FALSE TRUE
ENST00000460370 ENSG00000154222 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D1B protein_coding retained_intron 24.51361 29.79306 14.93449 2.463819 1.019027 -0.9958465 3.465759 3.271415 1.6521980 1.6143211 0.6780118 -0.9812259 0.13727917 0.10450000 0.10590000 0.001400000 9.561914e-01 5.4107e-11   FALSE
ENST00000491136 ENSG00000154222 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D1B protein_coding retained_intron 24.51361 29.79306 14.93449 2.463819 1.019027 -0.9958465 1.563747 1.150959 1.2589961 0.1602956 0.1559391 0.1283706 0.06800833 0.03830000 0.08560000 0.047300000 8.504908e-03 5.4107e-11 TRUE TRUE
ENST00000494789 ENSG00000154222 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D1B protein_coding processed_transcript 24.51361 29.79306 14.93449 2.463819 1.019027 -0.9958465 1.252187 0.590321 1.1740554 0.1220156 0.1845439 0.9799306 0.05454167 0.02023333 0.07783333 0.057600000 5.300601e-05 5.4107e-11   FALSE
MSTRG.1189.6 ENSG00000154222 HEK293_OSMI2_2hA HEK293_TMG_2hB CC2D1B protein_coding   24.51361 29.79306 14.93449 2.463819 1.019027 -0.9958465 7.173050 9.712925 4.7664906 1.4310500 0.2215102 -1.0254394 0.29888750 0.32830000 0.32116667 -0.007133333 1.000000e+00 5.4107e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000154222 E001 4.9149068 0.0328690012 2.424069e-01 3.770010e-01 1 52345723 52346203 481 - 0.847 0.663 -0.742
ENSG00000154222 E002 0.7029582 0.0172671820 8.489757e-01 9.062760e-01 1 52346885 52346917 33 - 0.177 0.213 0.328
ENSG00000154222 E003 4.6856263 0.0035390000 3.755306e-04 1.679489e-03 1 52350315 52350592 278 - 1.002 0.521 -1.965
ENSG00000154222 E004 1.5457931 0.0090402978 4.970393e-02 1.086324e-01 1 52350593 52350596 4 - 0.604 0.265 -1.841
ENSG00000154222 E005 137.8735137 0.0030700647 1.457826e-09 2.095453e-08 1 52350597 52352531 1935 - 2.252 2.009 -0.812
ENSG00000154222 E006 6.1903214 0.0026200281 1.698572e-01 2.880282e-01 1 52352532 52352537 6 - 0.655 0.852 0.795
ENSG00000154222 E007 371.2506529 0.0013122002 2.279158e-06 1.750647e-05 1 52352538 52353088 551 - 2.413 2.541 0.425
ENSG00000154222 E008 208.7133017 0.0032174804 6.326928e-05 3.474153e-04 1 52353089 52353223 135 - 2.136 2.297 0.538
ENSG00000154222 E009 31.3146104 0.0047358643 2.259558e-03 8.028854e-03 1 52353224 52353517 294 - 1.599 1.380 -0.751
ENSG00000154222 E010 89.4902148 0.0003503341 5.111803e-01 6.462826e-01 1 52353518 52353518 1 - 1.875 1.901 0.089
ENSG00000154222 E011 102.4308626 0.0003335666 6.481581e-01 7.597268e-01 1 52353519 52353530 12 - 1.939 1.956 0.056
ENSG00000154222 E012 168.9892533 0.0025961037 8.942836e-03 2.613609e-02 1 52353531 52353602 72 - 2.089 2.193 0.350
ENSG00000154222 E013 171.9149563 0.0013549705 1.128167e-04 5.808394e-04 1 52353603 52353647 45 - 2.069 2.207 0.464
ENSG00000154222 E014 9.6433853 0.0142768487 7.779785e-01 8.571577e-01 1 52354365 52354454 90 - 0.932 0.968 0.138
ENSG00000154222 E015 181.6762837 0.0002238428 2.398969e-02 5.978788e-02 1 52354608 52354654 47 - 2.150 2.217 0.223
ENSG00000154222 E016 152.8751427 0.0002712825 9.840279e-02 1.880857e-01 1 52354655 52354698 44 - 2.087 2.140 0.177
ENSG00000154222 E017 162.6178295 0.0006173272 3.947638e-01 5.385888e-01 1 52354840 52354886 47 - 2.134 2.161 0.090
ENSG00000154222 E018 171.4515956 0.0002657606 5.091556e-02 1.107961e-01 1 52354887 52354939 53 - 2.131 2.190 0.199
ENSG00000154222 E019 1.3338826 0.1708828005 4.279994e-01 5.708003e-01 1 52354940 52354965 26 - 0.177 0.360 1.358
ENSG00000154222 E020 163.8933520 0.0003468214 7.945539e-01 8.687459e-01 1 52355398 52355449 52 - 2.162 2.153 -0.031
ENSG00000154222 E021 7.3315450 0.0556330604 3.252107e-01 4.686505e-01 1 52355450 52355607 158 - 0.981 0.814 -0.634
ENSG00000154222 E022 139.5487283 0.0002912799 8.214193e-02 1.629020e-01 1 52355608 52355666 59 - 2.129 2.071 -0.196
ENSG00000154222 E023 120.0132539 0.0002984669 2.406953e-02 5.995661e-02 1 52355771 52355844 74 - 2.082 2.001 -0.270
ENSG00000154222 E024 91.6034237 0.0003742665 4.639170e-01 6.036781e-01 1 52356186 52356254 69 - 1.932 1.901 -0.104
ENSG00000154222 E025 84.4094156 0.0003772814 1.883090e-01 3.116039e-01 1 52356255 52356302 48 - 1.832 1.888 0.189
ENSG00000154222 E026 95.3091194 0.0004619718 2.593012e-01 3.966914e-01 1 52356384 52356442 59 - 1.892 1.937 0.153
ENSG00000154222 E027 2.7439808 0.1034630474 4.241034e-01 5.670926e-01 1 52356443 52356560 118 - 0.656 0.488 -0.764
ENSG00000154222 E028 5.6183510 0.0028935860 2.856135e-05 1.707382e-04 1 52356755 52357000 246 - 1.099 0.572 -2.079
ENSG00000154222 E029 112.1013824 0.0003141071 2.247858e-01 3.561780e-01 1 52357001 52357126 126 - 1.959 2.004 0.150
ENSG00000154222 E030 3.1300673 0.0166982764 2.403200e-02 5.988151e-02 1 52357127 52357174 48 - 0.815 0.461 -1.549
ENSG00000154222 E031 175.8697111 0.0002405140 2.186422e-01 3.487916e-01 1 52357526 52357698 173 - 2.159 2.195 0.120
ENSG00000154222 E032 145.8070170 0.0002443480 2.611651e-01 3.988015e-01 1 52357781 52357898 118 - 2.078 2.114 0.121
ENSG00000154222 E033 19.3576055 0.0026421272 1.120096e-01 2.084960e-01 1 52357899 52357916 18 - 1.345 1.209 -0.476
ENSG00000154222 E034 25.3493094 0.0009312890 2.304020e-14 7.185014e-13 1 52357917 52358330 414 - 1.684 1.161 -1.810
ENSG00000154222 E035 147.6420271 0.0007052941 4.761681e-01 6.148330e-01 1 52358331 52358461 131 - 2.090 2.114 0.079
ENSG00000154222 E036 109.6172442 0.0003161130 7.117546e-01 8.086586e-01 1 52358686 52358758 73 - 1.971 1.984 0.043
ENSG00000154222 E037 125.2668394 0.0002452563 9.586070e-01 9.780623e-01 1 52359027 52359157 131 - 2.040 2.040 0.002
ENSG00000154222 E038 116.5983981 0.0003369089 5.963727e-01 7.183386e-01 1 52359250 52359357 108 - 1.994 2.012 0.062
ENSG00000154222 E039 104.7902606 0.0064032259 7.615465e-01 8.453809e-01 1 52359459 52359534 76 - 1.978 1.963 -0.050
ENSG00000154222 E040 138.0950715 0.0002525265 6.798571e-01 7.839272e-01 1 52359705 52359820 116 - 2.092 2.077 -0.050
ENSG00000154222 E041 80.3024083 0.0004233472 1.045858e-01 1.974927e-01 1 52359821 52359836 16 - 1.900 1.829 -0.240
ENSG00000154222 E042 87.3307607 0.0008509259 9.274636e-01 9.583572e-01 1 52359837 52359883 47 - 1.889 1.884 -0.017
ENSG00000154222 E043 126.3673332 0.0016873737 3.960844e-01 5.398656e-01 1 52360074 52360233 160 - 2.019 2.053 0.112
ENSG00000154222 E044 132.0791267 0.0033040602 1.559760e-01 2.697644e-01 1 52360424 52360549 126 - 2.106 2.045 -0.203
ENSG00000154222 E045 5.8553978 0.0252290062 3.480909e-04 1.572472e-03 1 52360550 52360973 424 - 1.081 0.576 -1.997
ENSG00000154222 E046 139.4210891 0.0022988597 2.279318e-02 5.731422e-02 1 52360974 52361132 159 - 2.152 2.062 -0.299
ENSG00000154222 E047 3.9300263 0.0505591765 8.233010e-03 2.437480e-02 1 52361478 52361512 35 - 0.931 0.491 -1.845
ENSG00000154222 E048 135.6631810 0.0069516299 4.351810e-02 9.749733e-02 1 52361513 52361616 104 - 2.148 2.047 -0.340
ENSG00000154222 E049 154.4245796 0.0009177042 2.918087e-03 1.002489e-02 1 52362602 52362746 145 - 2.201 2.101 -0.334
ENSG00000154222 E050 102.3205152 0.0036751045 2.338702e-02 5.855239e-02 1 52364552 52364634 83 - 2.032 1.925 -0.357
ENSG00000154222 E051 69.0152551 0.0035186302 2.710846e-02 6.621561e-02 1 52366069 52366205 137 - 1.869 1.751 -0.396