ENSG00000154153

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000306320 ENSG00000154153 HEK293_OSMI2_2hA HEK293_TMG_2hB RETREG1 protein_coding protein_coding 1.943327 0.5711016 3.615376 0.02947871 0.1782125 2.641268 1.045641284 0.27060416 2.21985623 0.13669510 0.07816338 2.9903424 0.4876542 0.4526000 0.618966667 0.16636667 0.82585585 0.00337159 FALSE TRUE
ENST00000510362 ENSG00000154153 HEK293_OSMI2_2hA HEK293_TMG_2hB RETREG1 protein_coding nonsense_mediated_decay 1.943327 0.5711016 3.615376 0.02947871 0.1782125 2.641268 0.071177362 0.00000000 0.22487780 0.00000000 0.22487780 4.5538385 0.0230500 0.0000000 0.067033333 0.06703333 1.00000000 0.00337159 TRUE TRUE
ENST00000682033 ENSG00000154153 HEK293_OSMI2_2hA HEK293_TMG_2hB RETREG1 protein_coding protein_coding 1.943327 0.5711016 3.615376 0.02947871 0.1782125 2.641268 0.005883884 0.04707107 0.00000000 0.04707107 0.00000000 -2.5127596 0.0095875 0.0767000 0.000000000 -0.07670000 0.33616852 0.00337159 FALSE FALSE
ENST00000682142 ENSG00000154153 HEK293_OSMI2_2hA HEK293_TMG_2hB RETREG1 protein_coding protein_coding 1.943327 0.5711016 3.615376 0.02947871 0.1782125 2.641268 0.041600974 0.12148760 0.01842346 0.12148760 0.01842346 -2.2097726 0.0596750 0.2361333 0.004666667 -0.23146667 0.67986420 0.00337159 FALSE TRUE
ENST00000682808 ENSG00000154153 HEK293_OSMI2_2hA HEK293_TMG_2hB RETREG1 protein_coding processed_transcript 1.943327 0.5711016 3.615376 0.02947871 0.1782125 2.641268 0.131762074 0.12966526 0.15423548 0.01471636 0.02223331 0.2337927 0.1445417 0.2301333 0.042933333 -0.18720000 0.00337159 0.00337159 FALSE FALSE
ENST00000683539 ENSG00000154153 HEK293_OSMI2_2hA HEK293_TMG_2hB RETREG1 protein_coding protein_coding 1.943327 0.5711016 3.615376 0.02947871 0.1782125 2.641268 0.536599660 0.00000000 0.86444980 0.00000000 0.46829831 6.4503037 0.1476667 0.0000000 0.228366667 0.22836667 0.45226958 0.00337159 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000154153 E001 0.4418608 0.0247613357 1.000000e+00 1.000000e+00 5 16473038 16473052 15 - 0.152 0.000 -9.905
ENSG00000154153 E002 0.4418608 0.0247613357 1.000000e+00 1.000000e+00 5 16473053 16473070 18 - 0.152 0.000 -11.718
ENSG00000154153 E003 16.1772524 0.0011052776 3.881598e-04 1.729043e-03 5 16473071 16473346 276 - 1.054 1.376 1.143
ENSG00000154153 E004 32.4202972 0.0007155016 3.891194e-01 5.332305e-01 5 16473347 16474206 860 - 1.402 1.464 0.212
ENSG00000154153 E005 15.8062840 0.0026258205 2.764329e-01 4.158974e-01 5 16474207 16474648 442 - 1.099 1.209 0.393
ENSG00000154153 E006 3.3830524 0.0067663686 3.757909e-01 5.202018e-01 5 16474649 16474674 26 - 0.528 0.681 0.680
ENSG00000154153 E007 11.3055963 0.0171310242 8.646802e-01 9.167683e-01 5 16474675 16474824 150 - 0.996 0.970 -0.097
ENSG00000154153 E008 33.0892231 0.0006997911 1.027906e-01 1.947494e-01 5 16474825 16475234 410 - 1.446 1.317 -0.446
ENSG00000154153 E009 15.1256780 0.0013508828 7.037970e-01 8.024408e-01 5 16477662 16477788 127 - 1.109 1.066 -0.156
ENSG00000154153 E010 0.3686942 0.0278706154 2.153373e-01 3.448204e-01 5 16477789 16478033 245 - 0.057 0.246 2.449
ENSG00000154153 E011 8.7368149 0.0021469323 4.441087e-02 9.913053e-02 5 16478034 16478095 62 - 0.931 0.606 -1.309
ENSG00000154153 E012 6.1525876 0.0033801290 1.120367e-01 2.085361e-01 5 16478096 16478098 3 - 0.799 0.516 -1.218
ENSG00000154153 E013 0.4482035 0.0282140017 1.000000e+00 1.000000e+00 5 16478099 16478849 751 - 0.152 0.000 -11.715
ENSG00000154153 E014 13.4317576 0.0016494045 6.493448e-02 1.349264e-01 5 16478850 16478987 138 - 1.090 0.850 -0.894
ENSG00000154153 E015 0.7469680 0.0180277774 4.590556e-01 5.992909e-01 5 16478988 16481008 2021 - 0.230 0.000 -12.307
ENSG00000154153 E016 11.8397886 0.0016163780 7.248452e-01 8.182634e-01 5 16481009 16481073 65 - 1.015 0.971 -0.161
ENSG00000154153 E017 7.2891969 0.0189110376 5.672428e-01 6.940774e-01 5 16481074 16481093 20 - 0.808 0.893 0.328
ENSG00000154153 E018 1.9229976 0.0073943927 7.293940e-02 1.482246e-01 5 16481094 16482996 1903 - 0.449 0.000 -13.293
ENSG00000154153 E019 0.1472490 0.0434090386 1.000000e+00   5 16482997 16483345 349 - 0.057 0.000 -10.318
ENSG00000154153 E020 12.3355604 0.0020654524 3.859872e-01 5.301852e-01 5 16483346 16483472 127 - 1.043 0.934 -0.403
ENSG00000154153 E021 0.1472490 0.0434090386 1.000000e+00   5 16505404 16505523 120 - 0.057 0.000 -10.318
ENSG00000154153 E022 0.0000000       5 16508561 16508577 17 -      
ENSG00000154153 E023 0.0000000       5 16508578 16508882 305 -      
ENSG00000154153 E024 0.0000000       5 16508883 16508998 116 -      
ENSG00000154153 E025 0.0000000       5 16509343 16509436 94 -      
ENSG00000154153 E026 0.0000000       5 16528687 16528792 106 -      
ENSG00000154153 E027 0.2903454 0.2898055247 1.000000e+00   5 16564618 16564773 156 - 0.107 0.000 -10.932
ENSG00000154153 E028 0.0000000       5 16565314 16565762 449 -      
ENSG00000154153 E029 6.9943652 0.0024024672 5.341726e-02 1.152335e-01 5 16565763 16565793 31 - 0.853 0.516 -1.429
ENSG00000154153 E030 0.1515154 0.0429245200 1.000000e+00   5 16569329 16571995 2667 - 0.057 0.000 -10.319
ENSG00000154153 E031 10.5575156 0.0019079414 8.915765e-03 2.607065e-02 5 16571996 16572102 107 - 1.015 0.606 -1.621
ENSG00000154153 E032 6.9435199 0.0027065665 6.143607e-14 1.798621e-12 5 16613676 16615479 1804 - 0.470 1.347 3.445
ENSG00000154153 E033 3.8512000 0.0080006293 9.343108e-02 1.804821e-01 5 16615480 16616494 1015 - 0.528 0.801 1.167
ENSG00000154153 E034 0.5159433 0.2451742149 4.195363e-01 5.627891e-01 5 16616495 16616498 4 - 0.107 0.249 1.471
ENSG00000154153 E035 10.9102902 0.0015453586 6.852486e-03 2.084229e-02 5 16616652 16617101 450 - 1.026 0.606 -1.663