ENSG00000154124

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000284274 ENSG00000154124 HEK293_OSMI2_2hA HEK293_TMG_2hB OTULIN protein_coding protein_coding 8.246013 5.352872 10.84236 0.6661475 0.6577607 1.016931 3.4544657 2.3153010 4.3298673 0.3717441 0.08746597 0.9002335 0.41582083 0.4340000 0.40320000 -0.03080000 0.85865449 0.01576331 FALSE TRUE
ENST00000508678 ENSG00000154124 HEK293_OSMI2_2hA HEK293_TMG_2hB OTULIN protein_coding retained_intron 8.246013 5.352872 10.84236 0.6661475 0.6577607 1.016931 0.7564066 0.9337191 0.7680408 0.1958732 0.19061017 -0.2785117 0.10031250 0.1706333 0.06926667 -0.10136667 0.01576331 0.01576331   FALSE
MSTRG.25956.1 ENSG00000154124 HEK293_OSMI2_2hA HEK293_TMG_2hB OTULIN protein_coding   8.246013 5.352872 10.84236 0.6661475 0.6577607 1.016931 1.7071376 1.1974091 3.5071910 0.6650121 1.00867338 1.5425091 0.21315000 0.2018667 0.31536667 0.11350000 0.73348638 0.01576331 FALSE TRUE
MSTRG.25956.2 ENSG00000154124 HEK293_OSMI2_2hA HEK293_TMG_2hB OTULIN protein_coding   8.246013 5.352872 10.84236 0.6661475 0.6577607 1.016931 0.8272166 0.4817749 1.3076941 0.1093516 0.02413719 1.4219454 0.09215417 0.0986000 0.12146667 0.02286667 0.70914900 0.01576331 FALSE TRUE
MSTRG.25956.5 ENSG00000154124 HEK293_OSMI2_2hA HEK293_TMG_2hB OTULIN protein_coding   8.246013 5.352872 10.84236 0.6661475 0.6577607 1.016931 0.9222428 0.3097106 0.6189758 0.3097106 0.61897580 0.9762380 0.10465417 0.0765000 0.06356667 -0.01293333 0.96239670 0.01576331 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000154124 E001 0.8094222 0.1706518571 0.886826821 0.931631403 5 14664661 14664663 3 + 0.240 0.271 0.234
ENSG00000154124 E002 8.0418377 0.1314640262 0.272263354 0.411124470 5 14664664 14664717 54 + 1.033 0.812 -0.835
ENSG00000154124 E003 8.4794321 0.1430372705 0.232223797 0.365084161 5 14664718 14664726 9 + 1.061 0.811 -0.941
ENSG00000154124 E004 9.8520417 0.0852818213 0.089441332 0.174280196 5 14664727 14664731 5 + 1.130 0.842 -1.070
ENSG00000154124 E005 31.7368745 0.0730862039 0.018844287 0.048993285 5 14664732 14664977 246 + 1.614 1.293 -1.108
ENSG00000154124 E006 28.5102003 0.0006766545 0.014322929 0.038963756 5 14673642 14673718 77 + 1.524 1.370 -0.531
ENSG00000154124 E007 0.0000000       5 14673719 14674137 419 +      
ENSG00000154124 E008 40.7748662 0.0005834504 0.009868188 0.028440792 5 14678681 14678755 75 + 1.669 1.534 -0.459
ENSG00000154124 E009 30.6451511 0.0007218495 0.008565118 0.025203255 5 14678756 14678775 20 + 1.554 1.393 -0.555
ENSG00000154124 E010 51.5761020 0.0025901836 0.094977331 0.182844416 5 14681464 14681549 86 + 1.748 1.665 -0.281
ENSG00000154124 E011 33.4943351 0.0006435817 0.214322250 0.343639349 5 14681550 14681575 26 + 1.501 1.586 0.290
ENSG00000154124 E012 38.0544914 0.0007631362 0.043374292 0.097248739 5 14681576 14681607 32 + 1.533 1.657 0.423
ENSG00000154124 E013 1.0716670 0.0125327565 0.752044325 0.838366564 5 14681608 14681624 17 + 0.297 0.360 0.397
ENSG00000154124 E014 63.4688285 0.0008123208 0.038101121 0.087542516 5 14687521 14687646 126 + 1.761 1.863 0.345
ENSG00000154124 E015 7.1373325 0.0031890279 0.002188270 0.007805854 5 14687647 14687940 294 + 0.734 1.101 1.396
ENSG00000154124 E016 95.4212642 0.0054060493 0.621323662 0.738286085 5 14690039 14690308 270 + 1.968 1.995 0.093
ENSG00000154124 E017 88.2270959 0.0006692636 0.187628764 0.310756834 5 14692854 14693094 241 + 1.962 1.921 -0.137
ENSG00000154124 E018 70.2172428 0.0004322756 0.194170612 0.318998907 5 14693095 14693396 302 + 1.823 1.888 0.220
ENSG00000154124 E019 563.0805307 0.0088850869 0.349831043 0.494021316 5 14693397 14699850 6454 + 2.733 2.763 0.101
ENSG00000154124 E020 13.3512986 0.0017359541 0.228834692 0.361059440 5 14712722 14712845 124 + 1.098 1.218 0.429