ENSG00000154102

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000284245 ENSG00000154102 HEK293_OSMI2_2hA HEK293_TMG_2hB C16orf74 protein_coding protein_coding 8.405909 16.72108 5.555303 0.103089 0.4432855 -1.587998 3.5673344 8.2905635 2.0137973 0.30138515 0.3703804 -2.0361445 0.37962083 0.49610000 0.37830000 -0.117800000 5.696164e-01 8.371738e-06    
ENST00000602675 ENSG00000154102 HEK293_OSMI2_2hA HEK293_TMG_2hB C16orf74 protein_coding protein_coding 8.405909 16.72108 5.555303 0.103089 0.4432855 -1.587998 2.4517510 5.3392598 1.3974740 0.33388017 0.7163309 -1.9262310 0.28614167 0.31913333 0.23366667 -0.085466667 7.963719e-01 8.371738e-06    
ENST00000602914 ENSG00000154102 HEK293_OSMI2_2hA HEK293_TMG_2hB C16orf74 protein_coding protein_coding 8.405909 16.72108 5.555303 0.103089 0.4432855 -1.587998 0.8314890 1.1249010 0.4197961 0.13070023 0.2280892 -1.4008421 0.10923333 0.06726667 0.07103333 0.003766667 9.495785e-01 8.371738e-06    
MSTRG.13170.3 ENSG00000154102 HEK293_OSMI2_2hA HEK293_TMG_2hB C16orf74 protein_coding   8.405909 16.72108 5.555303 0.103089 0.4432855 -1.587998 0.6576080 0.7025457 0.5987938 0.11749448 0.3080306 -0.2270288 0.09915833 0.04210000 0.11753333 0.075433333 8.687197e-01 8.371738e-06    
MSTRG.13170.5 ENSG00000154102 HEK293_OSMI2_2hA HEK293_TMG_2hB C16orf74 protein_coding   8.405909 16.72108 5.555303 0.103089 0.4432855 -1.587998 0.2640815 0.1941422 0.5541058 0.02239954 0.1839217 1.4663915 0.04130833 0.01163333 0.09706667 0.085433333 8.371738e-06 8.371738e-06    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000154102 E001 0.6213751 0.0231329351 3.351848e-02 7.881021e-02 16 85690084 85690169 86 - 0.438 0.073 -3.258
ENSG00000154102 E002 3.8308474 0.0063276708 5.730556e-02 1.219967e-01 16 85690170 85690777 608 - 0.833 0.550 -1.191
ENSG00000154102 E003 5.3066962 0.0034499723 7.160482e-03 2.163893e-02 16 85701906 85701943 38 - 0.988 0.631 -1.413
ENSG00000154102 E004 5.1207254 0.0105525616 6.162414e-03 1.903960e-02 16 85701944 85701982 39 - 0.988 0.612 -1.497
ENSG00000154102 E005 6.0474998 0.0029082486 8.447342e-09 1.055344e-07 16 85701983 85702081 99 - 1.207 0.503 -2.789
ENSG00000154102 E006 3.5749417 0.0107296829 2.912882e-01 4.321420e-01 16 85707517 85707531 15 - 0.438 0.631 0.908
ENSG00000154102 E007 17.8185256 0.0014768981 1.542589e-01 2.674609e-01 16 85707532 85707621 90 - 1.081 1.221 0.502
ENSG00000154102 E008 31.9118271 0.0035499559 1.043403e-01 1.970960e-01 16 85707622 85707653 32 - 1.329 1.457 0.441
ENSG00000154102 E009 202.7484008 0.0006399168 1.678787e-06 1.327661e-05 16 85707654 85708066 413 - 2.122 2.240 0.396
ENSG00000154102 E010 83.1236354 0.0053913005 9.382646e-01 9.652167e-01 16 85710164 85710285 122 - 1.832 1.829 -0.010
ENSG00000154102 E011 20.2461568 0.0176808993 8.975833e-01 9.386175e-01 16 85710286 85710307 22 - 1.223 1.236 0.046
ENSG00000154102 E012 3.6042014 0.0045579491 9.958144e-01 1.000000e+00 16 85710308 85710409 102 - 0.592 0.593 0.004
ENSG00000154102 E013 3.7202424 0.0046166881 7.139198e-01 8.102768e-01 16 85710410 85710473 64 - 0.652 0.593 -0.260
ENSG00000154102 E014 1.9917022 0.0075912635 9.243382e-01 9.563370e-01 16 85710474 85710850 377 - 0.438 0.421 -0.091
ENSG00000154102 E015 34.8949015 0.0006877125 5.729254e-02 1.219731e-01 16 85735190 85735235 46 - 1.555 1.432 -0.421
ENSG00000154102 E016 29.6889169 0.0008975895 2.569149e-04 1.204091e-03 16 85750926 85751129 204 - 1.576 1.331 -0.844