ENSG00000154040

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000327201 ENSG00000154040 HEK293_OSMI2_2hA HEK293_TMG_2hB CABYR protein_coding protein_coding 4.762265 7.746767 2.993486 0.3606996 0.155665 -1.368818 0.1245255 0.5580846 0.06162285 0.29317135 0.06162285 -2.9876140 0.02122083 0.07360000 0.02293333 -0.05066667 0.65758539 0.03072642 FALSE TRUE
ENST00000399481 ENSG00000154040 HEK293_OSMI2_2hA HEK293_TMG_2hB CABYR protein_coding protein_coding 4.762265 7.746767 2.993486 0.3606996 0.155665 -1.368818 0.3472971 0.6459861 0.27049506 0.08740813 0.15994366 -1.2256899 0.07367083 0.08303333 0.09556667 0.01253333 0.91509901 0.03072642 TRUE TRUE
ENST00000399496 ENSG00000154040 HEK293_OSMI2_2hA HEK293_TMG_2hB CABYR protein_coding protein_coding 4.762265 7.746767 2.993486 0.3606996 0.155665 -1.368818 3.1282412 5.6086936 1.39924599 0.61336612 0.21275717 -1.9953113 0.62845833 0.72186667 0.46256667 -0.25930000 0.04477075 0.03072642 FALSE TRUE
ENST00000625720 ENSG00000154040 HEK293_OSMI2_2hA HEK293_TMG_2hB CABYR protein_coding processed_transcript 4.762265 7.746767 2.993486 0.3606996 0.155665 -1.368818 0.6621736 0.5042105 0.82170299 0.14133409 0.22879335 0.6937094 0.15380000 0.06570000 0.27756667 0.21186667 0.03072642 0.03072642   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000154040 E001 1.1760376 0.012802946 0.1819066567 0.303611002 18 24138987 24139016 30 + 0.000 0.304 10.424
ENSG00000154040 E002 2.4337494 0.122181211 0.4991711320 0.635510292 18 24139017 24139031 15 + 0.546 0.410 -0.677
ENSG00000154040 E003 2.9391217 0.117983212 0.7870218785 0.863625712 18 24139032 24139057 26 + 0.546 0.489 -0.271
ENSG00000154040 E004 2.9391217 0.117983212 0.7870218785 0.863625712 18 24139058 24139061 4 + 0.546 0.489 -0.271
ENSG00000154040 E005 2.9391217 0.117983212 0.7870218785 0.863625712 18 24139062 24139062 1 + 0.546 0.489 -0.271
ENSG00000154040 E006 2.9391217 0.117983212 0.7870218785 0.863625712 18 24139063 24139067 5 + 0.546 0.489 -0.271
ENSG00000154040 E007 15.6319813 0.010550246 0.6767392891 0.781621378 18 24139068 24139094 27 + 1.152 1.098 -0.196
ENSG00000154040 E008 15.6288608 0.014002324 0.5324045151 0.664771384 18 24139095 24139096 2 + 1.171 1.093 -0.282
ENSG00000154040 E009 16.4372508 0.019404198 0.4437839279 0.585368382 18 24139097 24139118 22 + 1.207 1.111 -0.342
ENSG00000154040 E010 0.0000000       18 24139484 24139519 36 +      
ENSG00000154040 E011 0.0000000       18 24139625 24139798 174 +      
ENSG00000154040 E012 0.5870335 0.081310278 0.0015062476 0.005656513 18 24139951 24140267 317 + 0.546 0.000 -15.339
ENSG00000154040 E013 19.0805887 0.009146448 0.7262266781 0.819293297 18 24143091 24143129 39 + 1.223 1.179 -0.158
ENSG00000154040 E014 29.1645093 0.004823240 0.7636679831 0.846936901 18 24143130 24143259 130 + 1.350 1.365 0.054
ENSG00000154040 E015 17.9893131 0.006802286 0.3936397170 0.537523523 18 24143360 24143413 54 + 1.090 1.173 0.298
ENSG00000154040 E016 0.3268771 0.028438531 0.3468637246   18 24148575 24148725 151 + 0.212 0.068 -1.899
ENSG00000154040 E017 0.3268771 0.028438531 0.3468637246   18 24150538 24150624 87 + 0.212 0.068 -1.899
ENSG00000154040 E018 0.1817044 0.040251399 1.0000000000   18 24150625 24150631 7 + 0.000 0.068 10.214
ENSG00000154040 E019 0.2924217 0.029078516 0.0244177827   18 24152644 24152657 14 + 0.354 0.000 -14.692
ENSG00000154040 E020 0.2924217 0.029078516 0.0244177827   18 24152658 24152822 165 + 0.354 0.000 -14.692
ENSG00000154040 E021 12.0434302 0.001686114 0.2942952568 0.435402995 18 24155701 24155703 3 + 0.898 1.019 0.450
ENSG00000154040 E022 53.8185771 0.001064258 0.4208929331 0.564050418 18 24155704 24156042 339 + 1.595 1.633 0.130
ENSG00000154040 E023 2.3827355 0.280128118 0.1314228047 0.236126554 18 24156043 24156103 61 + 0.735 0.343 -1.879
ENSG00000154040 E024 15.8894978 0.031555545 0.0800731093 0.159668344 18 24156104 24156771 668 + 1.285 1.072 -0.756
ENSG00000154040 E025 9.6001330 0.001937163 0.9903175819 0.998072589 18 24156772 24156999 228 + 0.932 0.925 -0.026
ENSG00000154040 E026 72.1598981 0.007885812 0.1006788769 0.191499108 18 24159472 24159815 344 + 1.677 1.770 0.315
ENSG00000154040 E027 47.3158993 0.004438705 0.5062069039 0.641879597 18 24159816 24159942 127 + 1.543 1.580 0.126
ENSG00000154040 E028 18.3053574 0.001373942 0.3597300583 0.504058966 18 24159943 24159945 3 + 1.112 1.195 0.295
ENSG00000154040 E029 33.7177809 0.016625169 0.8116106735 0.880433853 18 24159946 24160069 124 + 1.417 1.436 0.065
ENSG00000154040 E030 4.2101534 0.028372868 0.0004075486 0.001803482 18 24160070 24160265 196 + 1.018 0.478 -2.233
ENSG00000154040 E031 12.6555203 0.004760725 0.8576191319 0.912074885 18 24161516 24161600 85 + 1.018 1.032 0.051