ENSG00000154001

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337537 ENSG00000154001 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R5E protein_coding protein_coding 13.5457 5.515021 20.96558 0.1001626 0.5084071 1.924659 3.101886 1.9718243 4.914430 0.14495112 0.1855290 1.313128 0.27264583 0.35836667 0.23433333 -0.1240333 1.346319e-02 4.465524e-11 FALSE TRUE
ENST00000422769 ENSG00000154001 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R5E protein_coding protein_coding 13.5457 5.515021 20.96558 0.1001626 0.5084071 1.924659 6.526630 3.0756722 9.317640 0.21102214 0.3795303 1.595927 0.50606250 0.55680000 0.44413333 -0.1126667 7.423407e-02 4.465524e-11 FALSE TRUE
ENST00000555899 ENSG00000154001 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R5E protein_coding protein_coding 13.5457 5.515021 20.96558 0.1001626 0.5084071 1.924659 1.036484 0.1324923 1.858843 0.06645815 0.4029721 3.713190 0.05540833 0.02446667 0.08876667 0.0643000 1.207716e-01 4.465524e-11 FALSE TRUE
MSTRG.9686.5 ENSG00000154001 HEK293_OSMI2_2hA HEK293_TMG_2hB PPP2R5E protein_coding   13.5457 5.515021 20.96558 0.1001626 0.5084071 1.924659 2.141959 0.1901255 4.078741 0.02287498 0.1641926 4.352679 0.11440000 0.03450000 0.19503333 0.1605333 4.465524e-11 4.465524e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000154001 E001 160.02711 0.0151350184 8.134713e-05 4.343341e-04 14 63371364 63373051 1688 - 2.065 2.341 0.921
ENSG00000154001 E002 17.00115 0.0011767694 6.432002e-01 7.557953e-01 14 63373052 63373189 138 - 1.196 1.253 0.199
ENSG00000154001 E003 44.39063 0.0005013047 1.627637e-01 2.787505e-01 14 63373190 63373667 478 - 1.626 1.556 -0.238
ENSG00000154001 E004 32.09032 0.0013176772 4.937253e-01 6.307303e-01 14 63373668 63373891 224 - 1.478 1.444 -0.116
ENSG00000154001 E005 460.50622 0.0001643807 4.768422e-19 2.727546e-17 14 63373892 63375716 1825 - 2.564 2.728 0.544
ENSG00000154001 E006 69.20051 0.0048013750 2.041386e-01 3.313437e-01 14 63375717 63375760 44 - 1.768 1.853 0.288
ENSG00000154001 E007 71.76874 0.0010644800 2.613131e-01 3.989523e-01 14 63375761 63375797 37 - 1.790 1.858 0.230
ENSG00000154001 E008 82.21990 0.0023452771 7.141610e-01 8.104642e-01 14 63375798 63375842 45 - 1.861 1.892 0.106
ENSG00000154001 E009 95.73476 0.0003391401 2.411695e-01 3.755545e-01 14 63375843 63375904 62 - 1.918 1.980 0.208
ENSG00000154001 E010 170.55976 0.0001908470 9.787491e-01 9.908001e-01 14 63375905 63376108 204 - 2.180 2.196 0.054
ENSG00000154001 E011 66.55503 0.0003820032 2.815760e-02 6.832546e-02 14 63382056 63382070 15 - 1.804 1.709 -0.322
ENSG00000154001 E012 100.54893 0.0002679657 1.518762e-01 2.642271e-01 14 63382071 63382157 87 - 1.968 1.926 -0.141
ENSG00000154001 E013 74.51612 0.0003796950 1.975385e-02 5.096637e-02 14 63384444 63384530 87 - 1.855 1.760 -0.322
ENSG00000154001 E014 49.69937 0.0005192651 6.364982e-02 1.327798e-01 14 63384531 63384571 41 - 1.682 1.590 -0.313
ENSG00000154001 E015 76.58488 0.0003771330 4.234494e-01 5.664981e-01 14 63389612 63389731 120 - 1.846 1.825 -0.072
ENSG00000154001 E016 72.87419 0.0004570283 1.417296e-03 5.364364e-03 14 63391817 63391867 51 - 1.855 1.713 -0.479
ENSG00000154001 E017 75.63421 0.0003308825 4.644685e-02 1.028417e-01 14 63391972 63392025 54 - 1.855 1.777 -0.264
ENSG00000154001 E018 100.13939 0.0009491362 5.147695e-02 1.117757e-01 14 63393820 63393928 109 - 1.972 1.905 -0.227
ENSG00000154001 E019 70.33229 0.0004807824 4.092392e-01 5.528453e-01 14 63395226 63395285 60 - 1.810 1.786 -0.083
ENSG00000154001 E020 84.88889 0.0004840440 3.147861e-02 7.484254e-02 14 63396586 63396716 131 - 1.903 1.822 -0.275
ENSG00000154001 E021 65.40041 0.0006797234 1.304408e-03 4.991841e-03 14 63415140 63415232 93 - 1.810 1.656 -0.522
ENSG00000154001 E022 76.61118 0.0013817869 5.625726e-05 3.129392e-04 14 63421993 63422094 102 - 1.885 1.694 -0.648
ENSG00000154001 E023 1.05897 0.0668717032 5.418730e-01 6.727665e-01 14 63451274 63453688 2415 - 0.320 0.200 -0.899
ENSG00000154001 E024 102.15333 0.0033946257 7.226221e-05 3.911500e-04 14 63453689 63453885 197 - 2.006 1.822 -0.621
ENSG00000154001 E025 0.00000       14 63508125 63508238 114 -      
ENSG00000154001 E026 68.32567 0.0023447085 3.768758e-03 1.249249e-02 14 63539529 63539689 161 - 1.825 1.679 -0.493
ENSG00000154001 E027 15.73576 0.0012012145 1.702149e-02 4.498200e-02 14 63539690 63539692 3 - 1.226 0.989 -0.854
ENSG00000154001 E028 71.81863 0.0005735227 1.572093e-03 5.868191e-03 14 63542779 63543377 599 - 1.847 1.704 -0.483