ENSG00000153982

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000284116 ENSG00000153982 HEK293_OSMI2_2hA HEK293_TMG_2hB GDPD1 protein_coding protein_coding 5.402615 1.235181 7.265253 0.2431281 0.547108 2.546642 2.74179473 0.88353458 3.62968660 0.10895216 0.01416728 2.026219 0.62972083 0.76340000 0.505900000 -0.25750000 3.541190e-01 2.159448e-05 FALSE TRUE
ENST00000578026 ENSG00000153982 HEK293_OSMI2_2hA HEK293_TMG_2hB GDPD1 protein_coding nonsense_mediated_decay 5.402615 1.235181 7.265253 0.2431281 0.547108 2.546642 0.68505774 0.09936227 0.62657812 0.09936227 0.34086240 2.541222 0.08298333 0.06843333 0.092166667 0.02373333 8.780534e-01 2.159448e-05 FALSE TRUE
ENST00000579020 ENSG00000153982 HEK293_OSMI2_2hA HEK293_TMG_2hB GDPD1 protein_coding nonsense_mediated_decay 5.402615 1.235181 7.265253 0.2431281 0.547108 2.546642 1.07607113 0.00000000 2.14581275 0.00000000 0.58773803 7.752088 0.10753333 0.00000000 0.287833333 0.28783333 2.159448e-05 2.159448e-05 TRUE TRUE
ENST00000581276 ENSG00000153982 HEK293_OSMI2_2hA HEK293_TMG_2hB GDPD1 protein_coding protein_coding 5.402615 1.235181 7.265253 0.2431281 0.547108 2.546642 0.60201119 0.13730136 0.81103816 0.13730136 0.30816674 2.478679 0.11192917 0.09130000 0.106433333 0.01513333 7.061868e-01 2.159448e-05 FALSE TRUE
ENST00000583543 ENSG00000153982 HEK293_OSMI2_2hA HEK293_TMG_2hB GDPD1 protein_coding retained_intron 5.402615 1.235181 7.265253 0.2431281 0.547108 2.546642 0.06252892 0.11498260 0.05213731 0.08929457 0.02606885 -1.008196 0.03237500 0.07690000 0.007666667 -0.06923333 2.221891e-01 2.159448e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153982 E001 0.7415677 0.0349937029 4.883690e-02 0.1070908149 17 59220467 59220510 44 + 0.118 0.482 2.708
ENSG00000153982 E002 1.4758502 0.0556205311 4.482977e-01 0.5895899239 17 59220511 59220521 11 + 0.320 0.481 0.897
ENSG00000153982 E003 1.4758502 0.0556205311 4.482977e-01 0.5895899239 17 59220522 59220529 8 + 0.320 0.481 0.897
ENSG00000153982 E004 6.6367394 0.0450306492 6.067792e-01 0.7268576386 17 59220530 59220561 32 + 0.798 0.888 0.350
ENSG00000153982 E005 20.8365149 0.0234746932 6.427285e-01 0.7554566133 17 59220562 59220681 120 + 1.272 1.204 -0.240
ENSG00000153982 E006 21.7633614 0.0088075755 7.242753e-01 0.8178394867 17 59220682 59220751 70 + 1.283 1.240 -0.152
ENSG00000153982 E007 18.7147368 0.0202588750 3.558301e-01 0.5001961972 17 59234492 59234534 43 + 1.238 1.122 -0.413
ENSG00000153982 E008 30.5033379 0.0006688634 2.381327e-02 0.0594310576 17 59245414 59245549 136 + 1.455 1.272 -0.636
ENSG00000153982 E009 21.7880841 0.0134890741 2.993532e-02 0.0718313391 17 59248740 59248785 46 + 1.324 1.074 -0.888
ENSG00000153982 E010 0.6589510 0.0293679346 1.544543e-02 0.0415030752 17 59248786 59249228 443 + 0.063 0.483 3.716
ENSG00000153982 E011 31.7099728 0.0127978532 5.146266e-02 0.1117517455 17 59257122 59257240 119 + 1.472 1.284 -0.651
ENSG00000153982 E012 24.6331511 0.0089630130 6.084770e-01 0.7282004920 17 59257751 59257840 90 + 1.324 1.368 0.155
ENSG00000153982 E013 11.3892297 0.0015711993 3.757131e-01 0.5201186430 17 59267041 59267043 3 + 1.001 1.099 0.361
ENSG00000153982 E014 28.4089489 0.0007170681 9.595322e-01 0.9785876959 17 59267044 59267174 131 + 1.391 1.395 0.013
ENSG00000153982 E015 22.4789193 0.0009104291 4.226474e-01 0.5657766572 17 59270936 59270995 60 + 1.310 1.239 -0.250
ENSG00000153982 E016 16.9598407 0.0053734657 9.776598e-01 0.9901088313 17 59272785 59272805 21 + 1.180 1.184 0.012
ENSG00000153982 E017 20.7243534 0.0011689469 1.271459e-01 0.2301623503 17 59272806 59272836 31 + 1.290 1.144 -0.516
ENSG00000153982 E018 1.1040340 0.0213073472 5.201926e-01 0.6542015627 17 59272837 59273021 185 + 0.250 0.374 0.811
ENSG00000153982 E019 28.6362288 0.0009088329 1.421775e-02 0.0387204489 17 59273651 59273863 213 + 1.431 1.222 -0.729
ENSG00000153982 E020 56.4122045 0.0037714336 1.028298e-01 0.1947962126 17 59273864 59275119 1256 + 1.658 1.749 0.308
ENSG00000153982 E021 62.1381313 0.0016429965 4.255852e-03 0.0138577610 17 59275120 59275838 719 + 1.685 1.826 0.478
ENSG00000153982 E022 14.6668530 0.0013508828 3.135801e-05 0.0001856883 17 59275839 59275970 132 + 1.001 1.383 1.361