ENSG00000153975

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368576 ENSG00000153975 HEK293_OSMI2_2hA HEK293_TMG_2hB ZUP1 protein_coding protein_coding 14.82491 6.237076 23.69242 0.7375353 0.5287705 1.923782 8.936645 3.6820693 14.498622 0.47282009 0.6540179 1.974409 0.59557500 0.58906667 0.61266667 0.02360000 0.85852267 0.03787111 FALSE TRUE
ENST00000485498 ENSG00000153975 HEK293_OSMI2_2hA HEK293_TMG_2hB ZUP1 protein_coding processed_transcript 14.82491 6.237076 23.69242 0.7375353 0.5287705 1.923782 2.320759 1.6672669 3.573781 0.34781541 0.4429572 1.095370 0.18691250 0.26076667 0.15063333 -0.11013333 0.03787111 0.03787111   FALSE
MSTRG.28861.5 ENSG00000153975 HEK293_OSMI2_2hA HEK293_TMG_2hB ZUP1 protein_coding   14.82491 6.237076 23.69242 0.7375353 0.5287705 1.923782 1.328343 0.1697818 1.325314 0.09101708 0.1472094 2.892860 0.07715417 0.02420000 0.05613333 0.03193333 0.22029685 0.03787111 TRUE TRUE
MSTRG.28861.6 ENSG00000153975 HEK293_OSMI2_2hA HEK293_TMG_2hB ZUP1 protein_coding   14.82491 6.237076 23.69242 0.7375353 0.5287705 1.923782 1.170383 0.3872790 2.151710 0.09450637 0.2908479 2.443949 0.07199167 0.06663333 0.09096667 0.02433333 0.66069175 0.03787111 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153975 E001 0.0000000       6 116635537 116635614 78 -      
ENSG00000153975 E002 0.0000000       6 116635615 116635617 3 -      
ENSG00000153975 E003 1.0234925 0.0349493951 2.402284e-02 0.0598634022 6 116635618 116635669 52 - 0.129 0.538 2.822
ENSG00000153975 E004 1.1717857 0.0136279437 6.510562e-03 0.0199486727 6 116635670 116635676 7 - 0.129 0.608 3.141
ENSG00000153975 E005 3.3538018 0.0048093722 1.834104e-03 0.0067084742 6 116635677 116635693 17 - 0.408 0.888 2.110
ENSG00000153975 E006 66.0479528 0.0089532949 8.360147e-05 0.0004450515 6 116635694 116635879 186 - 1.687 1.944 0.867
ENSG00000153975 E007 149.9090488 0.0013480583 1.822122e-05 0.0001140841 6 116645714 116645934 221 - 2.075 2.229 0.515
ENSG00000153975 E008 28.3770519 0.0047154980 4.119670e-02 0.0932448216 6 116645935 116646258 324 - 1.358 1.524 0.572
ENSG00000153975 E009 98.5854874 0.0004730125 7.049192e-03 0.0213517983 6 116647459 116647610 152 - 1.910 2.023 0.382
ENSG00000153975 E010 33.5026903 0.0006203238 8.333873e-01 0.8956156948 6 116651572 116651576 5 - 1.476 1.499 0.079
ENSG00000153975 E011 101.0507822 0.0003798416 6.703578e-01 0.7768254731 6 116651577 116651737 161 - 1.952 1.944 -0.028
ENSG00000153975 E012 132.9494309 0.0002662705 6.044559e-01 0.7250003411 6 116652004 116652192 189 - 2.069 2.060 -0.031
ENSG00000153975 E013 129.0895499 0.0004096166 4.478942e-02 0.0998179565 6 116656684 116656852 169 - 2.070 2.006 -0.215
ENSG00000153975 E014 99.8774250 0.0003331521 1.318231e-02 0.0363367180 6 116658803 116658924 122 - 1.966 1.871 -0.318
ENSG00000153975 E015 0.9254501 0.0136968632 5.450437e-01 0.6754482623 6 116660233 116660369 137 - 0.229 0.347 0.819
ENSG00000153975 E016 84.3556137 0.0003092042 1.634393e-02 0.0434832125 6 116660736 116660846 111 - 1.897 1.798 -0.336
ENSG00000153975 E017 124.7495043 0.0002838202 1.634571e-01 0.2796550906 6 116666634 116666912 279 - 2.050 2.008 -0.140
ENSG00000153975 E018 104.0891749 0.0003368241 5.509148e-02 0.1181582216 6 116666913 116667207 295 - 1.978 1.909 -0.231
ENSG00000153975 E019 4.0395803 0.1144137130 1.125188e-01 0.2092217028 6 116668145 116668155 11 - 0.727 0.346 -1.834
ENSG00000153975 E020 10.7357302 0.0164834618 6.303206e-02 0.1317609772 6 116668156 116668285 130 - 1.069 0.813 -0.965
ENSG00000153975 E021 14.4575674 0.0014697591 2.840155e-02 0.0688186775 6 116668286 116668565 280 - 1.187 0.952 -0.856
ENSG00000153975 E022 71.0852208 0.0006322206 8.008780e-04 0.0032629505 6 116668566 116668794 229 - 1.835 1.671 -0.555