ENSG00000153956

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356860 ENSG00000153956 HEK293_OSMI2_2hA HEK293_TMG_2hB CACNA2D1 protein_coding protein_coding 4.201043 1.730479 6.956714 0.03084357 0.2863415 2.000994 1.6459312 0.55023395 3.064713 0.05341478 0.1212912 2.4563504 0.3703958 0.31910000 0.4421000 0.1230000 1.704373e-01 3.052695e-14 FALSE TRUE
MSTRG.30140.15 ENSG00000153956 HEK293_OSMI2_2hA HEK293_TMG_2hB CACNA2D1 protein_coding   4.201043 1.730479 6.956714 0.03084357 0.2863415 2.000994 0.8806804 1.02791795 1.209114 0.06686036 0.0590949 0.2321403 0.3624917 0.59306667 0.1737333 -0.4193333 3.052695e-14 3.052695e-14 FALSE TRUE
MSTRG.30140.2 ENSG00000153956 HEK293_OSMI2_2hA HEK293_TMG_2hB CACNA2D1 protein_coding   4.201043 1.730479 6.956714 0.03084357 0.2863415 2.000994 0.8752121 0.02785539 1.518916 0.01540859 0.2718827 5.3358669 0.1383542 0.01623333 0.2202000 0.2039667 8.910678e-05 3.052695e-14 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153956 E001 83.2398984 0.0005242944 1.929286e-37 5.649110e-35 7 81946444 81947435 992 - 1.634 2.184 1.851
ENSG00000153956 E002 143.4486108 0.0017171199 1.177573e-03 4.565293e-03 7 81947436 81949778 2343 - 1.966 2.104 0.464
ENSG00000153956 E003 29.9508179 0.0136616137 1.550906e-01 2.685287e-01 7 81949779 81950101 323 - 1.340 1.174 -0.583
ENSG00000153956 E004 41.6546473 0.0008480801 2.046090e-03 7.368188e-03 7 81950102 81950508 407 - 1.488 1.199 -1.008
ENSG00000153956 E005 20.0470455 0.0009173433 2.759891e-01 4.153881e-01 7 81959275 81959357 83 - 1.175 1.048 -0.457
ENSG00000153956 E006 23.9992069 0.0011871874 9.098759e-01 9.467241e-01 7 81959720 81959829 110 - 1.231 1.224 -0.027
ENSG00000153956 E007 22.2585966 0.0063054301 5.943858e-01 7.166296e-01 7 81961894 81962023 130 - 1.204 1.146 -0.207
ENSG00000153956 E008 11.6293716 0.0014538024 6.860724e-02 1.410572e-01 7 81962440 81962495 56 - 0.971 0.672 -1.176
ENSG00000153956 E009 9.5861803 0.0022100542 1.969386e-01 3.224001e-01 7 81964056 81964108 53 - 0.890 0.672 -0.868
ENSG00000153956 E010 0.0000000       7 81964109 81964206 98 -      
ENSG00000153956 E011 14.7574313 0.0011839270 2.813751e-03 9.714371e-03 7 81964207 81964359 153 - 1.079 0.577 -1.986
ENSG00000153956 E012 12.0298801 0.0283790803 7.337058e-03 2.209374e-02 7 81965594 81965665 72 - 1.002 0.454 -2.292
ENSG00000153956 E013 0.2998086 0.0286567660 1.346390e-01   7 81967165 81967168 4 - 0.047 0.284 3.011
ENSG00000153956 E014 10.0269353 0.0414035291 2.854592e-02 6.910662e-02 7 81967169 81967207 39 - 0.927 0.455 -2.011
ENSG00000153956 E015 10.7623758 0.0038941523 3.560368e-02 8.281661e-02 7 81967596 81967663 68 - 0.950 0.577 -1.510
ENSG00000153956 E016 14.0336561 0.0012649212 4.896137e-02 1.073104e-01 7 81968887 81968973 87 - 1.049 0.750 -1.140
ENSG00000153956 E017 17.7783491 0.0019908880 1.789749e-03 6.566653e-03 7 81969881 81969984 104 - 1.155 0.672 -1.844
ENSG00000153956 E018 16.2455656 0.0034755980 1.831808e-05 1.146375e-04 7 81970675 81970737 63 - 1.130 0.284 -3.754
ENSG00000153956 E019 0.0000000       7 81970738 81971089 352 -      
ENSG00000153956 E020 14.5827601 0.0017944744 3.672715e-02 8.494834e-02 7 81971777 81971864 88 - 1.066 0.750 -1.203
ENSG00000153956 E021 17.7855190 0.0009996083 1.020607e-01 1.936511e-01 7 81974455 81974552 98 - 1.137 0.924 -0.781
ENSG00000153956 E022 13.3276000 0.0012711049 1.602180e-01 2.754115e-01 7 81982567 81982627 61 - 1.021 0.816 -0.776
ENSG00000153956 E023 0.6017953 0.1139843769 1.000000e+00 1.000000e+00 7 81983314 81983334 21 - 0.164 0.000 -9.202
ENSG00000153956 E024 14.3468156 0.0012086258 2.062666e-01 3.340439e-01 7 81984635 81984711 77 - 1.049 0.874 -0.655
ENSG00000153956 E025 12.9054102 0.0013360954 1.774671e-03 6.518527e-03 7 81991185 81991246 62 - 1.031 0.455 -2.396
ENSG00000153956 E026 14.8315388 0.0011824425 8.268400e-02 1.637491e-01 7 81994868 81994939 72 - 1.066 0.816 -0.940
ENSG00000153956 E027 13.1846173 0.0013343762 1.709822e-01 2.894526e-01 7 81997179 81997235 57 - 1.017 0.816 -0.759
ENSG00000153956 E028 2.6593684 0.0058303807 9.984713e-01 1.000000e+00 7 81997236 81997250 15 - 0.452 0.455 0.013
ENSG00000153956 E029 1.0330470 0.0119745084 4.625281e-01 6.023838e-01 7 82001659 82001715 57 - 0.256 0.000 -10.423
ENSG00000153956 E030 0.1451727 0.0427789878 6.969362e-01   7 82005331 82005422 92 - 0.047 0.000 -7.610
ENSG00000153956 E031 9.9319864 0.0017924929 1.581102e-01 2.725946e-01 7 82005423 82005446 24 - 0.908 0.672 -0.940
ENSG00000153956 E032 13.3190552 0.0013728304 2.587303e-02 6.368238e-02 7 82005447 82005497 51 - 1.031 0.672 -1.395
ENSG00000153956 E033 18.2863643 0.0010520471 1.549735e-02 4.162308e-02 7 82005765 82005839 75 - 1.155 0.816 -1.259
ENSG00000153956 E034 0.0000000       7 82007662 82007678 17 -      
ENSG00000153956 E035 18.1757331 0.0015314851 9.782569e-02 1.871961e-01 7 82007679 82007756 78 - 1.141 0.924 -0.793
ENSG00000153956 E036 0.2903454 0.3226274262 1.000000e+00   7 82012043 82012153 111 - 0.089 0.001 -7.607
ENSG00000153956 E037 18.5783336 0.0056320249 1.790157e-02 4.692549e-02 7 82012154 82012243 90 - 1.158 0.817 -1.270
ENSG00000153956 E038 0.0000000       7 82012244 82012251 8 -      
ENSG00000153956 E039 13.3681966 0.0069649287 8.863562e-03 2.594122e-02 7 82013461 82013510 50 - 1.035 0.577 -1.825
ENSG00000153956 E040 16.6214809 0.0264079294 1.091337e-02 3.095465e-02 7 82014401 82014479 79 - 1.122 0.674 -1.717
ENSG00000153956 E041 15.7599210 0.0020187422 2.155235e-02 5.475136e-02 7 82032797 82032901 105 - 1.095 0.750 -1.307
ENSG00000153956 E042 0.0000000       7 82033019 82033072 54 -      
ENSG00000153956 E043 19.3689406 0.0011019837 8.980166e-03 2.623062e-02 7 82038077 82038235 159 - 1.179 0.816 -1.343
ENSG00000153956 E044 1.1897566 0.0125405682 3.426428e-03 1.151444e-02 7 82050336 82050628 293 - 0.128 0.672 3.429
ENSG00000153956 E045 0.8930711 0.0646503544 6.809028e-01 7.847318e-01 7 82050935 82051112 178 - 0.197 0.284 0.686
ENSG00000153956 E046 17.4184367 0.0010395905 8.553609e-03 2.517386e-02 7 82060428 82060527 100 - 1.137 0.750 -1.459
ENSG00000153956 E047 10.7314970 0.0142076341 1.858203e-03 6.783261e-03 7 82064304 82064354 51 - 0.961 0.284 -3.137
ENSG00000153956 E048 17.9553201 0.0010575476 1.950350e-02 5.042208e-02 7 82066455 82066524 70 - 1.144 0.816 -1.221
ENSG00000153956 E049 22.1483653 0.0012035344 1.630284e-02 4.339583e-02 7 82084769 82084900 132 - 1.228 0.924 -1.105
ENSG00000153956 E050 21.7862388 0.0008401680 6.604795e-03 2.019886e-02 7 82117044 82117173 130 - 1.228 0.874 -1.298
ENSG00000153956 E051 12.4879461 0.0274732463 2.698078e-01 4.083687e-01 7 82136635 82136676 42 - 0.996 0.815 -0.690
ENSG00000153956 E052 15.0556003 0.0115972642 1.719898e-01 2.907919e-01 7 82170550 82170609 60 - 1.070 0.873 -0.735
ENSG00000153956 E053 12.5397077 0.0015225486 1.533577e-19 9.308075e-18 7 82299906 82300151 246 - 0.709 1.590 3.201
ENSG00000153956 E054 29.6275634 0.0008968968 6.544031e-09 8.350714e-08 7 82335135 82335251 117 - 1.234 1.674 1.518
ENSG00000153956 E055 0.0000000       7 82343054 82343236 183 -      
ENSG00000153956 E056 23.5042341 0.0009208538 1.917478e-03 6.969428e-03 7 82349568 82349649 82 - 1.175 1.459 0.990
ENSG00000153956 E057 28.7889917 0.0007593070 1.190435e-03 4.608744e-03 7 82443365 82443807 443 - 1.265 1.535 0.936