ENSG00000153944

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000284073 ENSG00000153944 HEK293_OSMI2_2hA HEK293_TMG_2hB MSI2 protein_coding protein_coding 22.09961 19.99815 30.7504 1.625498 0.7341801 0.6204862 2.6296608 1.0459553 5.128528 0.2264247 0.4171020 2.282806 0.10822083 0.05446667 0.1664667 0.11200000 3.402999e-03 6.501141e-22 FALSE TRUE
ENST00000581523 ENSG00000153944 HEK293_OSMI2_2hA HEK293_TMG_2hB MSI2 protein_coding processed_transcript 22.09961 19.99815 30.7504 1.625498 0.7341801 0.6204862 5.6592073 10.5802468 3.598544 0.2106915 0.1926939 -1.553247 0.30661667 0.53486667 0.1169333 -0.41793333 6.501141e-22 6.501141e-22 FALSE FALSE
ENST00000582453 ENSG00000153944 HEK293_OSMI2_2hA HEK293_TMG_2hB MSI2 protein_coding processed_transcript 22.09961 19.99815 30.7504 1.625498 0.7341801 0.6204862 2.5415263 0.3844745 5.207610 0.3844745 1.3703095 3.725385 0.09405417 0.02036667 0.1674333 0.14706667 6.433336e-02 6.501141e-22 FALSE FALSE
ENST00000675379 ENSG00000153944 HEK293_OSMI2_2hA HEK293_TMG_2hB MSI2 protein_coding protein_coding 22.09961 19.99815 30.7504 1.625498 0.7341801 0.6204862 0.6849793 2.0357574 0.000000 1.2928001 0.0000000 -7.676491 0.04026250 0.09483333 0.0000000 -0.09483333 1.216925e-01 6.501141e-22   FALSE
MSTRG.14732.14 ENSG00000153944 HEK293_OSMI2_2hA HEK293_TMG_2hB MSI2 protein_coding   22.09961 19.99815 30.7504 1.625498 0.7341801 0.6204862 1.8011462 0.0000000 4.031449 0.0000000 0.9231129 8.658729 0.06604167 0.00000000 0.1325667 0.13256667 5.401204e-12 6.501141e-22 FALSE TRUE
MSTRG.14732.6 ENSG00000153944 HEK293_OSMI2_2hA HEK293_TMG_2hB MSI2 protein_coding   22.09961 19.99815 30.7504 1.625498 0.7341801 0.6204862 6.5967789 3.1285016 10.716194 0.7574279 0.3526739 1.772990 0.27803333 0.15256667 0.3494000 0.19683333 1.049973e-03 6.501141e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

No results under this category.

Splicing

All exons whithin this gene region are shown and numbering below.

No results under this category.

Transcripts

All isoforms whithin this gene region are shown below.

No results under this category.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153944 E001 1.1717857 0.0133758594 4.015075e-02 9.131490e-02 17 57255851 57255981 131 + 0.158 0.534 2.467
ENSG00000153944 E002 0.1472490 0.0446154142 1.000000e+00   17 57256523 57256542 20 + 0.086 0.000 -30.210
ENSG00000153944 E003 2.4099203 0.0464503743 6.728859e-01 7.787297e-01 17 57256543 57256735 193 + 0.533 0.469 -0.309
ENSG00000153944 E004 4.7027686 0.1671227371 6.184516e-01 7.360692e-01 17 57256736 57256739 4 + 0.766 0.656 -0.453
ENSG00000153944 E005 4.8510618 0.0807775718 6.896676e-01 7.915155e-01 17 57256740 57256740 1 + 0.765 0.694 -0.291
ENSG00000153944 E006 5.7314579 0.0652019458 7.632441e-01 8.466168e-01 17 57256741 57256742 2 + 0.781 0.839 0.227
ENSG00000153944 E007 28.5175955 0.0041885513 8.992216e-01 9.397040e-01 17 57256743 57256758 16 + 1.443 1.463 0.072
ENSG00000153944 E008 40.1253527 0.0005547229 1.786405e-01 2.994471e-01 17 57256759 57256773 15 + 1.556 1.667 0.377
ENSG00000153944 E009 46.6240879 0.0007200670 1.551133e-01 2.685551e-01 17 57256774 57256781 8 + 1.620 1.730 0.373
ENSG00000153944 E010 58.8364627 0.0004419852 3.039855e-01 4.459608e-01 17 57256782 57256804 23 + 1.729 1.812 0.282
ENSG00000153944 E011 0.5997190 0.1464448858 2.013932e-01 3.279214e-01 17 57257013 57257017 5 + 0.274 0.000 -32.214
ENSG00000153944 E012 0.8964071 0.1669281732 9.933476e-02 1.894733e-01 17 57257018 57257041 24 + 0.365 0.000 -32.799
ENSG00000153944 E013 1.7121589 0.0100705056 2.800836e-01 4.198827e-01 17 57257042 57257051 10 + 0.473 0.294 -1.025
ENSG00000153944 E014 3.5932231 0.0044958244 2.431296e-01 3.778567e-01 17 57257052 57257097 46 + 0.694 0.534 -0.703
ENSG00000153944 E015 75.0416242 0.0003490478 3.275194e-01 4.709886e-01 17 57257098 57257123 26 + 1.836 1.913 0.257
ENSG00000153944 E016 71.7934781 0.0003795061 2.928304e-01 4.338457e-01 17 57257124 57257138 15 + 1.817 1.897 0.271
ENSG00000153944 E017 59.0896385 0.0012196096 8.585499e-01 9.127342e-01 17 57257466 57257469 4 + 1.746 1.788 0.144
ENSG00000153944 E018 123.5429062 0.0004912835 4.690546e-02 1.036558e-01 17 57257470 57257547 78 + 2.040 2.141 0.336
ENSG00000153944 E019 151.6868977 0.0080759337 1.690636e-02 4.472766e-02 17 57258270 57258354 85 + 2.110 2.252 0.474
ENSG00000153944 E020 0.0000000       17 57259977 57260054 78 +      
ENSG00000153944 E021 0.1515154 0.0438974628 1.000000e+00   17 57262115 57262150 36 + 0.086 0.000 -30.211
ENSG00000153944 E022 129.2309229 0.0089095913 7.668687e-03 2.294853e-02 17 57262151 57262192 42 + 2.031 2.195 0.547
ENSG00000153944 E023 0.5546650 0.0307175553 2.343699e-01 3.676100e-01 17 57262193 57262433 241 + 0.086 0.295 2.148
ENSG00000153944 E024 0.0000000       17 57263488 57263569 82 +      
ENSG00000153944 E025 1.1018414 0.0253890609 1.215986e-02 3.391409e-02 17 57263570 57268550 4981 + 0.086 0.535 3.471
ENSG00000153944 E026 43.7661279 0.0133785460 6.088871e-29 9.355380e-27 17 57274268 57274489 222 + 1.069 1.999 3.203
ENSG00000153944 E027 0.0000000       17 57285844 57286012 169 +      
ENSG00000153944 E028 0.0000000       17 57294685 57294789 105 +      
ENSG00000153944 E029 0.1817044 0.0460841604 2.348301e-01   17 57310131 57310326 196 + 0.000 0.172 32.227
ENSG00000153944 E030 2.5755135 0.0065493017 1.791499e-02 4.695288e-02 17 57364922 57365021 100 + 0.364 0.766 1.880
ENSG00000153944 E031 0.2924217 0.0274779265 4.968002e-01   17 57370949 57370991 43 + 0.158 0.000 -31.210
ENSG00000153944 E032 116.5925470 0.0004684684 2.209230e-09 3.069991e-08 17 57401379 57401471 93 + 2.111 1.925 -0.622
ENSG00000153944 E033 0.0000000       17 57406812 57407039 228 +      
ENSG00000153944 E034 0.1817044 0.0460841604 2.348301e-01   17 57432586 57432614 29 + 0.000 0.172 32.227
ENSG00000153944 E035 0.0000000       17 57440690 57440739 50 +      
ENSG00000153944 E036 0.0000000       17 57444487 57444752 266 +      
ENSG00000153944 E037 0.1515154 0.0438974628 1.000000e+00   17 57487061 57487289 229 + 0.086 0.000 -30.211
ENSG00000153944 E038 0.0000000       17 57524309 57524378 70 +      
ENSG00000153944 E039 84.9264348 0.0003424622 6.120358e-06 4.271916e-05 17 57529676 57529724 49 + 1.968 1.815 -0.515
ENSG00000153944 E040 0.0000000       17 57556990 57557131 142 +      
ENSG00000153944 E041 0.6579068 0.5744394132 5.811303e-01 7.057224e-01 17 57565923 57565995 73 + 0.157 0.296 1.160
ENSG00000153944 E042 62.5074582 0.0020380779 1.658226e-05 1.047677e-04 17 57596868 57596902 35 + 1.848 1.652 -0.660
ENSG00000153944 E043 64.1350353 0.0024990716 8.535832e-05 4.533467e-04 17 57596903 57596950 48 + 1.853 1.675 -0.601
ENSG00000153944 E044 94.6068563 0.0003837048 1.026391e-07 1.040045e-06 17 57615970 57616084 115 + 2.019 1.840 -0.602
ENSG00000153944 E045 0.5169874 0.0202952234 2.369336e-01 3.706277e-01 17 57616085 57616631 547 + 0.086 0.294 2.145
ENSG00000153944 E046 0.5901394 0.5081443759 3.493500e-01 4.935627e-01 17 57625572 57626914 1343 + 0.086 0.306 2.228
ENSG00000153944 E047 0.0000000       17 57626915 57627228 314 +      
ENSG00000153944 E048 66.2391103 0.0016452665 6.876894e-05 3.741768e-04 17 57627229 57627303 75 + 1.863 1.693 -0.574
ENSG00000153944 E049 6.3314312 0.0135367640 5.248456e-05 2.941729e-04 17 57627304 57631790 4487 + 0.559 1.118 2.207
ENSG00000153944 E050 33.9735087 0.0005883138 1.020468e-17 5.012307e-16 17 57631791 57632401 611 + 1.257 1.805 1.881
ENSG00000153944 E051 39.7654189 0.0084396612 1.830486e-15 6.686852e-14 17 57632402 57633183 782 + 1.287 1.879 2.022
ENSG00000153944 E052 0.0000000       17 57650650 57650673 24 +      
ENSG00000153944 E053 54.8028752 0.0006608574 3.737113e-08 4.130841e-07 17 57652099 57652161 63 + 1.806 1.542 -0.896
ENSG00000153944 E054 0.0000000       17 57655695 57655744 50 +      
ENSG00000153944 E055 0.1472490 0.0446154142 1.000000e+00   17 57671474 57671574 101 + 0.086 0.000 -30.210
ENSG00000153944 E056 16.8589818 0.0010611818 2.262090e-01 3.578529e-01 17 57674918 57674971 54 + 1.262 1.191 -0.252
ENSG00000153944 E057 75.3748212 0.0003551839 2.740446e-08 3.108798e-07 17 57674972 57675126 155 + 1.931 1.714 -0.730
ENSG00000153944 E058 68.4880015 0.0058108717 8.251071e-05 4.399000e-04 17 57676987 57677059 73 + 1.888 1.679 -0.706
ENSG00000153944 E059 75.9090904 0.0031016681 2.333005e-08 2.684529e-07 17 57679549 57679606 58 + 1.945 1.680 -0.896
ENSG00000153944 E060 1464.6934833 0.0187901611 8.967793e-01 9.380502e-01 17 57679607 57684689 5083 + 3.136 3.167 0.104
ENSG00000153944 E061 0.5879639 0.0212706193 7.502708e-01 8.369984e-01 17 57700368 57700433 66 + 0.219 0.171 -0.442