ENSG00000153933

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000284061 ENSG00000153933 HEK293_OSMI2_2hA HEK293_TMG_2hB DGKE protein_coding protein_coding 3.814644 1.101436 6.676701 0.1993256 0.2757776 2.58887 2.4874756 0.52984900 4.4340968 0.06924709 0.19214411 3.041262 0.62000833 0.53023333 0.66583333 0.13560000 0.713018986 0.000559652 FALSE TRUE
ENST00000570738 ENSG00000153933 HEK293_OSMI2_2hA HEK293_TMG_2hB DGKE protein_coding protein_coding 3.814644 1.101436 6.676701 0.1993256 0.2757776 2.58887 0.1324879 0.38409412 0.0000000 0.20200463 0.00000000 -5.300468 0.10784583 0.30790000 0.00000000 -0.30790000 0.017934113 0.000559652 FALSE FALSE
ENST00000572810 ENSG00000153933 HEK293_OSMI2_2hA HEK293_TMG_2hB DGKE protein_coding protein_coding 3.814644 1.101436 6.676701 0.1993256 0.2757776 2.58887 0.2320982 0.11199654 0.3791458 0.01911001 0.05321307 1.673471 0.07584583 0.10326667 0.05730000 -0.04596667 0.506648259 0.000559652 FALSE TRUE
ENST00000572944 ENSG00000153933 HEK293_OSMI2_2hA HEK293_TMG_2hB DGKE protein_coding protein_coding 3.814644 1.101436 6.676701 0.1993256 0.2757776 2.58887 0.2746063 0.04119267 0.5277175 0.02382266 0.18185259 3.392839 0.05994167 0.03546667 0.07916667 0.04370000 0.604170730 0.000559652 FALSE TRUE
MSTRG.14717.1 ENSG00000153933 HEK293_OSMI2_2hA HEK293_TMG_2hB DGKE protein_coding   3.814644 1.101436 6.676701 0.1993256 0.2757776 2.58887 0.3672477 0.00000000 0.6913317 0.00000000 0.07353646 6.132025 0.06469167 0.00000000 0.10306667 0.10306667 0.000559652 0.000559652 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153933 E001 1.519859 0.0088418966 0.7758034946 0.855612220 17 56834107 56834130 24 + 0.284 0.308 0.163
ENSG00000153933 E002 2.261528 0.0065648823 0.9912242375 0.998639932 17 56834131 56834150 20 + 0.368 0.486 0.632
ENSG00000153933 E003 10.110892 0.0017788875 0.7930083403 0.867643602 17 56834151 56834260 110 + 0.842 0.967 0.475
ENSG00000153933 E004 17.610299 0.0010894718 0.4777331034 0.616255308 17 56834778 56834965 188 + 1.043 1.292 0.888
ENSG00000153933 E005 32.369393 0.0006522018 0.3547935593 0.499116899 17 56834966 56835259 294 + 1.314 1.411 0.340
ENSG00000153933 E006 7.903586 0.0023831749 0.0077824309 0.023233606 17 56835260 56836466 1207 + 0.681 1.189 1.930
ENSG00000153933 E007 30.654952 0.0099169485 0.0003266758 0.001487436 17 56844019 56844178 160 + 1.322 1.054 -0.953
ENSG00000153933 E008 32.947194 0.0121333461 0.0041304754 0.013507322 17 56845690 56845809 120 + 1.345 1.189 -0.546
ENSG00000153933 E009 1.494980 0.1052559776 0.8089974004 0.878679163 17 56845810 56846302 493 + 0.284 0.307 0.150
ENSG00000153933 E010 0.894217 0.0134978499 0.4602362506 0.600286248 17 56847360 56847429 70 + 0.208 0.000 -21.235
ENSG00000153933 E011 1.933607 0.0076886659 0.1138347679 0.211109259 17 56847516 56847658 143 + 0.368 0.000 -22.351
ENSG00000153933 E012 31.373471 0.0006987753 0.0049746270 0.015859653 17 56847922 56848065 144 + 1.320 1.217 -0.360
ENSG00000153933 E013 35.625456 0.0087260696 0.2878913970 0.428427936 17 56848696 56848853 158 + 1.355 1.428 0.254
ENSG00000153933 E014 25.942069 0.0007653196 0.0033340411 0.011245867 17 56849181 56849232 52 + 1.246 1.092 -0.548
ENSG00000153933 E015 31.552746 0.0007513933 0.0342882057 0.080308465 17 56856512 56856625 114 + 1.316 1.292 -0.082
ENSG00000153933 E016 1.920921 0.0072470513 0.1138045860 0.211067749 17 56856626 56856665 40 + 0.368 0.000 -22.350
ENSG00000153933 E017 27.228664 0.0034020256 0.0050805134 0.016150212 17 56858594 56858665 72 + 1.265 1.127 -0.491
ENSG00000153933 E018 15.290501 0.0110513899 0.0023455224 0.008293402 17 56861791 56861794 4 + 1.047 0.710 -1.296
ENSG00000153933 E019 40.995012 0.0019963199 0.0021197477 0.007595609 17 56861795 56861918 124 + 1.432 1.336 -0.334
ENSG00000153933 E020 26.872135 0.0374108925 0.1949837351 0.319962959 17 56862140 56862185 46 + 1.248 1.242 -0.020
ENSG00000153933 E021 29.658945 0.0065030502 0.0572680379 0.121926434 17 56862186 56862251 66 + 1.291 1.268 -0.082
ENSG00000153933 E022 4.446392 0.0726163226 0.6732457261 0.778981217 17 56862252 56862611 360 + 0.575 0.610 0.156
ENSG00000153933 E023 20.891240 0.0353404559 0.0031243319 0.010631449 17 56862612 56862644 33 + 1.171 0.854 -1.173
ENSG00000153933 E024 520.740743 0.0421296081 0.0011500031 0.004471311 17 56862645 56869567 6923 + 2.463 2.778 1.050