ENSG00000153922

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000284049 ENSG00000153922 HEK293_OSMI2_2hA HEK293_TMG_2hB CHD1 protein_coding protein_coding 17.09135 3.987834 29.3204 0.3359528 0.3463978 2.875106 8.7313561 1.0684803 16.6161426 0.44455945 0.2727135 3.946382 0.42319167 0.2514333 0.566833333 0.31540000 1.250524e-01 1.45872e-07 FALSE TRUE
ENST00000512844 ENSG00000153922 HEK293_OSMI2_2hA HEK293_TMG_2hB CHD1 protein_coding nonsense_mediated_decay 17.09135 3.987834 29.3204 0.3359528 0.3463978 2.875106 2.4435725 0.2698120 3.1323670 0.26981202 0.8326145 3.489322 0.13080417 0.0617000 0.107500000 0.04580000 3.748577e-01 1.45872e-07 FALSE TRUE
ENST00000514344 ENSG00000153922 HEK293_OSMI2_2hA HEK293_TMG_2hB CHD1 protein_coding retained_intron 17.09135 3.987834 29.3204 0.3359528 0.3463978 2.875106 0.9496337 1.8734244 0.2292758 0.36989169 0.1102774 -2.976612 0.17269583 0.4904667 0.007733333 -0.48273333 1.458720e-07 1.45872e-07 FALSE TRUE
ENST00000614616 ENSG00000153922 HEK293_OSMI2_2hA HEK293_TMG_2hB CHD1 protein_coding protein_coding 17.09135 3.987834 29.3204 0.3359528 0.3463978 2.875106 0.7253026 0.3723974 1.1260138 0.10762662 0.1628538 1.570836 0.05476667 0.0992000 0.038533333 -0.06066667 2.137549e-01 1.45872e-07 FALSE TRUE
MSTRG.26670.4 ENSG00000153922 HEK293_OSMI2_2hA HEK293_TMG_2hB CHD1 protein_coding   17.09135 3.987834 29.3204 0.3359528 0.3463978 2.875106 2.2080540 0.1735937 5.1703293 0.09302954 0.5964295 4.818455 0.09278750 0.0422000 0.175966667 0.13376667 2.943296e-03 1.45872e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153922 E001 22.3574904 0.1477673691 5.847485e-03 1.821182e-02 5 98853985 98855203 1219 - 1.042 1.687 2.251
ENSG00000153922 E002 128.4013550 0.0518004584 9.360773e-07 7.814270e-06 5 98855204 98855731 528 - 1.783 2.399 2.066
ENSG00000153922 E003 192.5982277 0.0003022926 1.840383e-27 2.488615e-25 5 98855732 98856282 551 - 2.019 2.413 1.316
ENSG00000153922 E004 135.9751908 0.0030013531 2.159274e-05 1.328186e-04 5 98856283 98856424 142 - 1.901 2.143 0.814
ENSG00000153922 E005 151.9305616 0.0006788128 2.814499e-06 2.120326e-05 5 98856425 98856566 142 - 1.950 2.180 0.769
ENSG00000153922 E006 164.6821543 0.0008439615 1.066164e-06 8.795574e-06 5 98856567 98856725 159 - 1.984 2.216 0.778
ENSG00000153922 E007 163.4412183 0.0002550645 1.033963e-03 4.075934e-03 5 98858180 98858390 211 - 1.991 2.159 0.562
ENSG00000153922 E008 3.3375631 0.0821736103 6.027281e-01 7.236563e-01 5 98858391 98858664 274 - 0.475 0.606 0.611
ENSG00000153922 E009 69.0310447 0.0003729544 8.468109e-02 1.668859e-01 5 98858964 98859015 52 - 1.627 1.770 0.484
ENSG00000153922 E010 73.1186743 0.0003734622 1.559887e-01 2.697752e-01 5 98859972 98860068 97 - 1.655 1.777 0.414
ENSG00000153922 E011 7.2497141 0.0327351152 7.267609e-01 8.196813e-01 5 98860069 98860682 614 - 0.748 0.704 -0.184
ENSG00000153922 E012 121.3883222 0.0002828034 4.243092e-01 5.672877e-01 5 98863408 98863586 179 - 1.876 1.951 0.252
ENSG00000153922 E013 105.5243290 0.0009100237 1.885539e-02 4.901677e-02 5 98868495 98868635 141 - 1.804 1.961 0.529
ENSG00000153922 E014 0.4439371 0.0215659040 1.000000e+00 1.000000e+00 5 98868930 98869013 84 - 0.118 0.000 -9.106
ENSG00000153922 E015 14.9436390 0.0086532914 7.676675e-01 8.498501e-01 5 98869014 98869277 264 - 1.017 1.006 -0.042
ENSG00000153922 E016 2.1014797 0.0065663236 6.203264e-01 7.375304e-01 5 98869479 98869753 275 - 0.353 0.481 0.695
ENSG00000153922 E017 111.8603905 0.0025271770 3.647241e-01 5.090577e-01 5 98869754 98869882 129 - 1.840 1.926 0.289
ENSG00000153922 E018 119.3179384 0.0047346809 6.768622e-01 7.817052e-01 5 98870687 98870803 117 - 1.873 1.931 0.198
ENSG00000153922 E019 138.2528850 0.0002767135 5.121216e-01 6.470453e-01 5 98872051 98872201 151 - 1.942 1.946 0.013
ENSG00000153922 E020 1.7885478 0.0983781614 2.740151e-01 4.131161e-01 5 98872202 98872416 215 - 0.353 0.000 -11.110
ENSG00000153922 E021 127.2711438 0.0006878157 1.424392e-01 2.513594e-01 5 98872417 98872555 139 - 1.911 1.870 -0.140
ENSG00000153922 E022 0.3268771 0.0289517850 1.159321e-01   5 98872556 98872557 2 - 0.043 0.304 3.281
ENSG00000153922 E023 111.6929683 0.0003519115 1.536618e-01 2.666511e-01 5 98873593 98873723 131 - 1.855 1.812 -0.146
ENSG00000153922 E024 71.1375585 0.0003508217 4.979986e-01 6.345090e-01 5 98875072 98875113 42 - 1.660 1.649 -0.035
ENSG00000153922 E025 133.9352618 0.0002817071 2.170008e-01 3.467894e-01 5 98876398 98876558 161 - 1.930 1.904 -0.087
ENSG00000153922 E026 135.9477564 0.0002465428 8.024885e-02 1.599415e-01 5 98879552 98879728 177 - 1.939 1.887 -0.175
ENSG00000153922 E027 96.9409182 0.0026760647 4.760293e-02 1.049156e-01 5 98881076 98881171 96 - 1.800 1.706 -0.319
ENSG00000153922 E028 0.1451727 0.0428372437 6.349830e-01   5 98881247 98881278 32 - 0.043 0.000 -7.521
ENSG00000153922 E029 80.1029598 0.0047949062 1.326766e-01 2.378175e-01 5 98881279 98881375 97 - 1.716 1.641 -0.256
ENSG00000153922 E030 111.2944639 0.0005198384 5.771045e-02 1.227015e-01 5 98881975 98882123 149 - 1.856 1.784 -0.242
ENSG00000153922 E031 71.8338792 0.0006545455 1.069347e-02 3.043730e-02 5 98883088 98883133 46 - 1.676 1.525 -0.517
ENSG00000153922 E032 85.3118680 0.0003192484 3.157271e-02 7.501731e-02 5 98883134 98883237 104 - 1.744 1.640 -0.355
ENSG00000153922 E033 70.7314147 0.0003417007 5.344757e-02 1.152850e-01 5 98885578 98885649 72 - 1.665 1.562 -0.349
ENSG00000153922 E034 5.4310792 0.0291338748 1.066234e-01 2.005688e-01 5 98885650 98886231 582 - 0.668 0.305 -1.849
ENSG00000153922 E035 94.0903827 0.0002833128 1.153991e-01 2.134289e-01 5 98888088 98888240 153 - 1.782 1.722 -0.202
ENSG00000153922 E036 90.6600001 0.0003637258 1.616005e-01 2.771892e-01 5 98889076 98889238 163 - 1.764 1.714 -0.171
ENSG00000153922 E037 94.0905733 0.0003222840 1.220706e-03 4.710727e-03 5 98892525 98892713 189 - 1.793 1.619 -0.590
ENSG00000153922 E038 76.3812827 0.0003395252 3.307661e-02 7.796092e-02 5 98893416 98893606 191 - 1.698 1.586 -0.380
ENSG00000153922 E039 41.1884517 0.0006978050 3.212894e-03 1.089360e-02 5 98894597 98894686 90 - 1.448 1.182 -0.929
ENSG00000153922 E040 88.9902704 0.0049613869 1.488869e-04 7.422285e-04 5 98896226 98896442 217 - 1.775 1.512 -0.895
ENSG00000153922 E041 76.4300915 0.0011228454 1.929172e-03 7.006018e-03 5 98897193 98897320 128 - 1.705 1.511 -0.660
ENSG00000153922 E042 79.6529495 0.0003403070 2.775953e-04 1.288361e-03 5 98898256 98898434 179 - 1.726 1.497 -0.779
ENSG00000153922 E043 51.5676116 0.0005734435 5.314148e-04 2.277044e-03 5 98898664 98898764 101 - 1.547 1.261 -0.990
ENSG00000153922 E044 94.4520114 0.0002854143 4.263532e-07 3.824038e-06 5 98899480 98899705 226 - 1.805 1.483 -1.095
ENSG00000153922 E045 133.9527578 0.0002249168 3.337066e-11 6.376812e-10 5 98900811 98901082 272 - 1.957 1.586 -1.255
ENSG00000153922 E046 106.9083299 0.0004323494 2.817466e-12 6.424656e-11 5 98901186 98901335 150 - 1.865 1.386 -1.633
ENSG00000153922 E047 63.7173436 0.0003781631 9.820444e-08 9.986868e-07 5 98902900 98902964 65 - 1.644 1.182 -1.599
ENSG00000153922 E048 82.5375190 0.0003309710 2.920446e-07 2.709583e-06 5 98903792 98903908 117 - 1.748 1.386 -1.238
ENSG00000153922 E049 95.5587382 0.0003022156 8.169393e-06 5.537468e-05 5 98904897 98905098 202 - 1.806 1.538 -0.911
ENSG00000153922 E050 57.7566261 0.0004186514 1.008127e-04 5.256559e-04 5 98926334 98926534 201 - 1.596 1.285 -1.073
ENSG00000153922 E051 46.0764620 0.0004837430 9.666865e-03 2.794303e-02 5 98928539 98929015 477 - 1.491 1.285 -0.715