ENSG00000153815

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000537098 ENSG00000153815 HEK293_OSMI2_2hA HEK293_TMG_2hB CMIP protein_coding protein_coding 9.372567 12.12041 7.915763 0.7784503 0.4782023 -0.6140063 3.999790 3.636694 5.063047 0.9833300 0.4694494 0.4762634 0.4388125 0.2954000 0.6374000 0.342 0.002067858 0.002067858 FALSE TRUE
ENST00000539778 ENSG00000153815 HEK293_OSMI2_2hA HEK293_TMG_2hB CMIP protein_coding protein_coding 9.372567 12.12041 7.915763 0.7784503 0.4782023 -0.6140063 4.545378 7.920288 2.164892 0.8231913 0.4677894 -1.8664292 0.4695667 0.6539333 0.2819333 -0.372 0.008890376 0.002067858 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153815 E001 66.6520117 0.0116222029 2.500863e-05 0.0001516342 16 81444808 81445541 734 + 1.944 1.711 -0.787
ENSG00000153815 E002 0.0000000       16 81495349 81495494 146 +      
ENSG00000153815 E003 72.3392946 0.0059739929 7.712756e-05 0.0004144778 16 81607567 81607692 126 + 1.948 1.773 -0.589
ENSG00000153815 E004 0.0000000       16 81610307 81610540 234 +      
ENSG00000153815 E005 34.2219367 0.0006495635 1.328969e-01 0.2381404302 16 81620876 81620926 51 + 1.563 1.508 -0.188
ENSG00000153815 E006 0.0000000       16 81620927 81622200 1274 +      
ENSG00000153815 E007 0.0000000       16 81645358 81645359 2 +      
ENSG00000153815 E008 0.2214452 0.0378557997 7.154916e-01   16 81645360 81645598 239 + 0.000 0.105 10.346
ENSG00000153815 E009 0.0000000       16 81645599 81645781 183 +      
ENSG00000153815 E010 0.0000000       16 81651191 81651427 237 +      
ENSG00000153815 E011 83.8879477 0.0005005284 2.219717e-02 0.0560803801 16 81652203 81652364 162 + 1.943 1.889 -0.180
ENSG00000153815 E012 54.8982377 0.0163501111 1.995523e-01 0.3256657032 16 81657775 81657816 42 + 1.765 1.712 -0.181
ENSG00000153815 E013 59.1802298 0.0044142399 2.055861e-02 0.0526682743 16 81660884 81660946 63 + 1.814 1.727 -0.296
ENSG00000153815 E014 52.8785267 0.0062107140 3.800697e-01 0.5243373610 16 81664269 81664349 81 + 1.726 1.711 -0.050
ENSG00000153815 E015 2.1390410 0.0115740909 1.175278e-01 0.2164088702 16 81664350 81667276 2927 + 0.612 0.375 -1.174
ENSG00000153815 E016 52.6278457 0.0004726936 5.139125e-01 0.6486850307 16 81670142 81670245 104 + 1.665 1.734 0.233
ENSG00000153815 E017 58.8361983 0.0004510374 2.391422e-01 0.3730999068 16 81671966 81672070 105 + 1.768 1.749 -0.065
ENSG00000153815 E018 125.0011282 0.0004175485 1.141897e-02 0.0321598682 16 81678275 81678628 354 + 2.107 2.061 -0.153
ENSG00000153815 E019 0.0000000       16 81691656 81691774 119 +      
ENSG00000153815 E020 69.7222788 0.0043766845 1.594958e-01 0.2744508682 16 81691775 81691840 66 + 1.853 1.816 -0.126
ENSG00000153815 E021 56.6415015 0.0036831473 1.177305e-01 0.2166942756 16 81693158 81693184 27 + 1.771 1.722 -0.164
ENSG00000153815 E022 0.4396707 0.0248036460 3.670587e-02 0.0849160024 16 81693187 81693438 252 + 0.334 0.000 -13.198
ENSG00000153815 E023 66.1024709 0.0046234831 8.847694e-02 0.1727920228 16 81693439 81693487 49 + 1.839 1.785 -0.183
ENSG00000153815 E024 0.9651910 0.0123042799 1.834634e-01 0.3055541453 16 81695437 81696559 1123 + 0.406 0.190 -1.498
ENSG00000153815 E025 79.1472851 0.0004973283 6.048545e-01 0.7252902350 16 81696560 81696667 108 + 1.870 1.885 0.051
ENSG00000153815 E026 4.1255595 0.0040201976 3.926370e-01 0.5365742419 16 81696668 81698121 1454 + 0.751 0.659 -0.382
ENSG00000153815 E027 94.3154512 0.0003167293 3.586255e-01 0.5030200746 16 81699685 81699801 117 + 1.958 1.960 0.007
ENSG00000153815 E028 1.2501240 0.0348797698 2.118553e-01 0.3406907043 16 81700510 81700579 70 + 0.467 0.260 -1.236
ENSG00000153815 E029 119.1711611 0.0003503342 6.730874e-01 0.7788708197 16 81701660 81701800 141 + 2.024 2.075 0.170
ENSG00000153815 E030 66.9760671 0.0003704713 1.412334e-01 0.2497291958 16 81702622 81702669 48 + 1.741 1.844 0.346
ENSG00000153815 E031 1.4048591 0.0155071988 9.107372e-01 0.9472788919 16 81703857 81703938 82 + 0.334 0.375 0.241
ENSG00000153815 E032 132.6147389 0.0046897027 9.318145e-02 0.1800990254 16 81703939 81704085 147 + 2.026 2.144 0.396
ENSG00000153815 E033 125.9976037 0.0003823050 5.652630e-01 0.6923825765 16 81705499 81705604 106 + 2.043 2.099 0.187
ENSG00000153815 E034 111.3679907 0.0003780258 5.246735e-02 0.1135546900 16 81707014 81707084 71 + 2.046 2.016 -0.100
ENSG00000153815 E035 0.9912127 0.1398924198 4.079007e-01 0.5514956091 16 81707085 81707085 1 + 0.142 0.328 1.543
ENSG00000153815 E036 553.1404339 0.0112219844 4.840903e-05 0.0002737678 16 81709746 81711762 2017 + 2.579 2.796 0.721