ENSG00000153707

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356435 ENSG00000153707 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRD protein_coding protein_coding 0.9443035 0.2966407 1.50305 0.02279597 0.1904093 2.302838 0.17746063 0.13207739 0.19062490 0.08615762 0.100496183 0.4978237 0.27275417 0.46516667 0.13970000 -0.32546667 0.76081998 0.03016606 FALSE TRUE
ENST00000397606 ENSG00000153707 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRD protein_coding protein_coding 0.9443035 0.2966407 1.50305 0.02279597 0.1904093 2.302838 0.06997839 0.00000000 0.32912001 0.00000000 0.066375015 5.0837240 0.04661667 0.00000000 0.22600000 0.22600000 0.03016606 0.03016606 FALSE TRUE
ENST00000471274 ENSG00000153707 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRD protein_coding processed_transcript 0.9443035 0.2966407 1.50305 0.02279597 0.1904093 2.302838 0.15570892 0.02747162 0.38987677 0.02747162 0.080090353 3.4156854 0.12626250 0.08143333 0.25700000 0.17556667 0.28639926 0.03016606 FALSE FALSE
ENST00000477552 ENSG00000153707 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRD protein_coding retained_intron 0.9443035 0.2966407 1.50305 0.02279597 0.1904093 2.302838 0.06377151 0.00000000 0.11326123 0.00000000 0.001318759 3.6236472 0.04985833 0.00000000 0.07830000 0.07830000 0.34660483 0.03016606   FALSE
ENST00000481079 ENSG00000153707 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRD protein_coding protein_coding 0.9443035 0.2966407 1.50305 0.02279597 0.1904093 2.302838 0.11986631 0.00000000 0.10740502 0.00000000 0.053882727 3.5534222 0.10683333 0.00000000 0.06396667 0.06396667 0.63013682 0.03016606 TRUE FALSE
ENST00000488774 ENSG00000153707 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRD protein_coding processed_transcript 0.9443035 0.2966407 1.50305 0.02279597 0.1904093 2.302838 0.07293728 0.00000000 0.00000000 0.00000000 0.000000000 0.0000000 0.05528333 0.00000000 0.00000000 0.00000000   0.03016606 FALSE FALSE
ENST00000540109 ENSG00000153707 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRD protein_coding protein_coding 0.9443035 0.2966407 1.50305 0.02279597 0.1904093 2.302838 0.08838996 0.00000000 0.08865439 0.00000000 0.088654387 3.3023832 0.05860417 0.00000000 0.04936667 0.04936667 1.00000000 0.03016606 TRUE TRUE
ENST00000651105 ENSG00000153707 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRD protein_coding processed_transcript 0.9443035 0.2966407 1.50305 0.02279597 0.1904093 2.302838 0.16267917 0.13709174 0.24250563 0.07423038 0.047619849 0.7795993 0.20556667 0.45340000 0.16253333 -0.29086667 0.48945989 0.03016606 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153707 E001 0.0000000       9 8314246 8314246 1 -      
ENSG00000153707 E002 0.0000000       9 8314247 8314250 4 -      
ENSG00000153707 E003 31.5480975 0.001767703 2.841022e-14 8.737389e-13 9 8314251 8317276 3026 - 1.303 1.720 1.431
ENSG00000153707 E004 3.0486826 0.009813462 4.244395e-02 9.552507e-02 9 8317277 8317403 127 - 0.455 0.752 1.330
ENSG00000153707 E005 2.3865120 0.038682313 9.818094e-01 9.926576e-01 9 8317404 8317404 1 - 0.513 0.487 -0.126
ENSG00000153707 E006 4.1029373 0.004059462 6.450978e-01 7.572830e-01 9 8317405 8317471 67 - 0.708 0.612 -0.409
ENSG00000153707 E007 9.5571867 0.001906411 2.788241e-01 4.184879e-01 9 8317472 8317703 232 - 0.965 1.053 0.327
ENSG00000153707 E008 10.6144535 0.007352755 1.460354e-02 3.960259e-02 9 8317704 8317942 239 - 0.945 1.174 0.836
ENSG00000153707 E009 8.8732646 0.002446552 1.350169e-02 3.708095e-02 9 8319831 8319966 136 - 0.867 1.109 0.897
ENSG00000153707 E010 7.8683500 0.002410563 2.784587e-01 4.181278e-01 9 8331582 8331736 155 - 0.891 0.989 0.370
ENSG00000153707 E011 6.4655369 0.002643423 7.588365e-02 1.529199e-01 9 8338922 8339047 126 - 0.773 0.966 0.742
ENSG00000153707 E012 4.9541000 0.003478831 1.606681e-01 2.759924e-01 9 8340343 8340469 127 - 0.691 0.856 0.664
ENSG00000153707 E013 6.1403615 0.031788629 9.353538e-01 9.633051e-01 9 8341090 8341268 179 - 0.842 0.822 -0.077
ENSG00000153707 E014 7.7635755 0.019118561 6.047661e-01 7.252026e-01 9 8341693 8341978 286 - 0.955 0.855 -0.378
ENSG00000153707 E015 5.3404272 0.003531725 4.975769e-01 6.341156e-01 9 8375936 8376090 155 - 0.758 0.824 0.263
ENSG00000153707 E016 5.0104191 0.003331393 2.318040e-01 3.646015e-01 9 8376607 8376726 120 - 0.816 0.612 -0.843
ENSG00000153707 E017 5.0190274 0.004630400 3.814670e-02 8.763469e-02 9 8389232 8389407 176 - 0.842 0.486 -1.531
ENSG00000153707 E018 2.9100722 0.006932819 2.498159e-01 3.857026e-01 9 8404537 8404660 124 - 0.632 0.406 -1.088
ENSG00000153707 E019 1.4759519 0.010430369 1.862768e-01 3.090751e-01 9 8436592 8436646 55 - 0.455 0.180 -1.844
ENSG00000153707 E020 1.7916682 0.012252480 1.077741e-01 2.022474e-01 9 8436647 8436689 43 - 0.513 0.180 -2.134
ENSG00000153707 E021 0.0000000       9 8437198 8437239 42 -      
ENSG00000153707 E022 0.0000000       9 8438701 8438820 120 -      
ENSG00000153707 E023 2.6764220 0.008365087 1.525006e-03 5.717551e-03 9 8449725 8449837 113 - 0.672 0.000 -14.641
ENSG00000153707 E024 0.0000000       9 8454580 8454591 12 -      
ENSG00000153707 E025 0.0000000       9 8454592 8454594 3 -      
ENSG00000153707 E026 2.1057461 0.006852467 2.533759e-01 3.898931e-01 9 8460411 8460571 161 - 0.540 0.308 -1.259
ENSG00000153707 E027 3.3049686 0.044176526 3.626948e-01 5.071180e-01 9 8465466 8465675 210 - 0.672 0.484 -0.855
ENSG00000153707 E028 2.6688197 0.007399213 1.856951e-02 4.838380e-02 9 8470995 8471085 91 - 0.653 0.180 -2.761
ENSG00000153707 E029 3.6515141 0.004726915 2.298209e-01 3.622413e-01 9 8484119 8484237 119 - 0.708 0.486 -0.995
ENSG00000153707 E030 4.1172317 0.004191825 6.757536e-01 7.809305e-01 9 8484238 8484378 141 - 0.672 0.710 0.158
ENSG00000153707 E031 2.5660408 0.086253950 7.718894e-01 8.527799e-01 9 8485227 8485324 98 - 0.564 0.484 -0.380
ENSG00000153707 E032 0.4396707 0.049134192 3.814488e-01 5.257384e-01 9 8485325 8485327 3 - 0.208 0.000 -12.196
ENSG00000153707 E033 0.5933762 0.019300864 2.403102e-01 3.744997e-01 9 8485328 8485636 309 - 0.261 0.000 -12.599
ENSG00000153707 E034 1.3285892 0.010166973 2.435048e-01 3.782925e-01 9 8485762 8485762 1 - 0.422 0.180 -1.674
ENSG00000153707 E035 9.4235076 0.016845608 5.645332e-01 6.918198e-01 9 8485763 8486349 587 - 1.019 0.916 -0.382
ENSG00000153707 E036 3.2442460 0.007359438 2.165191e-01 3.462124e-01 9 8492862 8492979 118 - 0.540 0.710 0.743
ENSG00000153707 E037 0.5202097 0.021315070 8.011025e-01 8.732449e-01 9 8497242 8497268 27 - 0.150 0.181 0.329
ENSG00000153707 E038 4.3189979 0.003769850 8.036000e-01 8.750107e-01 9 8499647 8499840 194 - 0.725 0.663 -0.258
ENSG00000153707 E039 5.0458935 0.003295726 2.319556e-01 3.647745e-01 9 8500754 8501059 306 - 0.816 0.612 -0.843
ENSG00000153707 E040 4.2878770 0.004961873 5.670455e-01 6.939245e-01 9 8504261 8504405 145 - 0.726 0.612 -0.479
ENSG00000153707 E041 4.7341075 0.012062529 2.018954e-02 5.187993e-02 9 8507301 8507434 134 - 0.830 0.406 -1.894
ENSG00000153707 E042 10.0279525 0.001912133 2.386039e-04 1.127364e-03 9 8517848 8518429 582 - 1.125 0.612 -1.995
ENSG00000153707 E043 5.9878351 0.026764960 7.731924e-04 3.161986e-03 9 8521277 8521546 270 - 0.945 0.307 -2.925
ENSG00000153707 E044 0.0000000       9 8523513 8523524 12 -      
ENSG00000153707 E045 2.6826510 0.040029764 2.394272e-03 8.443083e-03 9 8524925 8524948 24 - 0.672 0.000 -14.623
ENSG00000153707 E046 3.2717609 0.007953810 3.970501e-04 1.762995e-03 9 8524949 8525035 87 - 0.742 0.000 -14.920
ENSG00000153707 E047 0.0000000       9 8526627 8526644 18 -      
ENSG00000153707 E048 0.0000000       9 8527345 8527353 9 -      
ENSG00000153707 E049 0.0000000       9 8528152 8528492 341 -      
ENSG00000153707 E050 2.8712498 0.008051611 7.739650e-02 1.552938e-01 9 8528591 8528779 189 - 0.652 0.308 -1.760
ENSG00000153707 E051 0.0000000       9 8534920 8534952 33 -      
ENSG00000153707 E052 1.6804584 0.135497986 5.753721e-01 7.009854e-01 9 8633317 8633389 73 - 0.454 0.308 -0.834
ENSG00000153707 E053 2.3134617 0.012110929 2.060105e-01 3.336988e-01 9 8633390 8633458 69 - 0.565 0.308 -1.372
ENSG00000153707 E054 0.0000000       9 8633459 8633460 2 -      
ENSG00000153707 E055 2.8744589 0.006411031 1.388646e-02 3.796940e-02 9 8636699 8636844 146 - 0.672 0.181 -2.842
ENSG00000153707 E056 1.5595994 0.008968046 1.847186e-01 3.071158e-01 9 8733780 8733946 167 - 0.455 0.181 -1.842
ENSG00000153707 E057 0.0000000       9 8733947 8733949 3 -      
ENSG00000153707 E058 0.4783925 0.020704516 8.012930e-01 8.733961e-01 9 8857638 8857776 139 - 0.150 0.181 0.327
ENSG00000153707 E059 0.0000000       9 9018697 9018735 39 -      
ENSG00000153707 E060 0.0000000       9 9183304 9183363 60 -      
ENSG00000153707 E061 0.0000000       9 9397449 9397482 34 -      
ENSG00000153707 E062 0.0000000       9 9414752 9414823 72 -      
ENSG00000153707 E063 0.0000000       9 9574732 9574781 50 -      
ENSG00000153707 E064 0.0000000       9 9734533 9734571 39 -      
ENSG00000153707 E065 0.0000000       9 9766810 9766851 42 -      
ENSG00000153707 E066 0.0000000       9 9938507 9938610 104 -      
ENSG00000153707 E067 0.0000000       9 10033718 10033790 73 -      
ENSG00000153707 E068 0.0000000       9 10340963 10341017 55 -      
ENSG00000153707 E069 0.0000000       9 10612398 10612505 108 -      
ENSG00000153707 E070 0.0000000       9 10612688 10613002 315 -