ENSG00000153560

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000447368 ENSG00000153560 HEK293_OSMI2_2hA HEK293_TMG_2hB UBP1 protein_coding protein_coding 51.32879 30.19153 77.70661 3.470041 1.99753 1.363601 17.74324 5.692298 42.33457 0.8027472 1.8240447 2.892562 0.3299625 0.1989000 0.5445000 0.34560000 1.327897e-04 8.175085e-52 FALSE TRUE
MSTRG.22687.1 ENSG00000153560 HEK293_OSMI2_2hA HEK293_TMG_2hB UBP1 protein_coding   51.32879 30.19153 77.70661 3.470041 1.99753 1.363601 13.33486 9.463014 21.94335 1.5604777 0.6693086 1.212546 0.2696792 0.3102000 0.2823667 -0.02783333 6.128758e-01 8.175085e-52 FALSE TRUE
MSTRG.22687.4 ENSG00000153560 HEK293_OSMI2_2hA HEK293_TMG_2hB UBP1 protein_coding   51.32879 30.19153 77.70661 3.470041 1.99753 1.363601 12.79544 13.833532 0.00000 3.0359975 0.0000000 -10.434996 0.2728000 0.4485667 0.0000000 -0.44856667 8.175085e-52 8.175085e-52 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153560 E001 6.0612149 0.0457132499 3.199253e-01 4.630061e-01 3 33388336 33388337 2 - 0.735 0.944 0.813
ENSG00000153560 E002 6.4341755 0.0654939281 3.016116e-01 4.434272e-01 3 33388338 33388338 1 - 0.750 0.973 0.860
ENSG00000153560 E003 2708.7858242 0.0039793834 4.439762e-21 3.232512e-19 3 33388339 33390096 1758 - 3.288 3.574 0.951
ENSG00000153560 E004 249.8078543 0.0005537254 5.705555e-05 3.168402e-04 3 33390097 33390133 37 - 2.304 2.484 0.598
ENSG00000153560 E005 388.7381131 0.0002287392 1.131134e-02 3.190833e-02 3 33390134 33390265 132 - 2.515 2.641 0.420
ENSG00000153560 E006 321.8271999 0.0001833698 2.365287e-02 5.909615e-02 3 33390266 33390368 103 - 2.434 2.558 0.415
ENSG00000153560 E007 65.3061709 0.0094868385 3.797922e-06 2.777904e-05 3 33390369 33392362 1994 - 1.846 1.579 -0.906
ENSG00000153560 E008 7.4610132 0.0022062775 3.552720e-02 8.266627e-02 3 33392363 33392562 200 - 0.949 0.733 -0.841
ENSG00000153560 E009 198.4935854 0.0003235226 3.250851e-01 4.685123e-01 3 33392563 33392614 52 - 2.249 2.298 0.161
ENSG00000153560 E010 19.3657773 0.0099779908 9.502052e-06 6.348787e-05 3 33392615 33393311 697 - 1.361 0.940 -1.511
ENSG00000153560 E011 277.9531183 0.0005331509 5.747850e-01 7.005412e-01 3 33393312 33393454 143 - 2.391 2.452 0.203
ENSG00000153560 E012 208.9055240 0.0002868979 9.035968e-02 1.756867e-01 3 33396162 33396242 81 - 2.277 2.307 0.100
ENSG00000153560 E013 180.9788295 0.0002097343 3.990039e-01 5.427553e-01 3 33396243 33396280 38 - 2.209 2.261 0.175
ENSG00000153560 E014 10.8289640 0.0109136611 2.112175e-02 5.385584e-02 3 33396281 33396581 301 - 1.098 0.880 -0.809
ENSG00000153560 E015 10.9313760 0.0191337892 1.277500e-02 3.538594e-02 3 33396582 33396744 163 - 1.111 0.846 -0.984
ENSG00000153560 E016 22.0187720 0.0008431380 2.580147e-04 1.208617e-03 3 33396745 33396878 134 - 1.382 1.136 -0.866
ENSG00000153560 E017 11.9485576 0.0016630171 4.251997e-05 2.436048e-04 3 33396879 33397044 166 - 1.166 0.733 -1.633
ENSG00000153560 E018 319.0600730 0.0003239295 5.874525e-05 3.252224e-04 3 33397045 33397135 91 - 2.473 2.455 -0.059
ENSG00000153560 E019 2.9676978 0.0049937790 5.862364e-03 1.825146e-02 3 33397136 33398438 1303 - 0.668 0.190 -2.732
ENSG00000153560 E020 367.3384113 0.0001445996 1.966606e-07 1.886801e-06 3 33400189 33400282 94 - 2.539 2.507 -0.105
ENSG00000153560 E021 295.6374009 0.0001649929 4.506686e-06 3.241621e-05 3 33400962 33401016 55 - 2.445 2.416 -0.097
ENSG00000153560 E022 360.0682808 0.0002354767 7.854497e-03 2.341628e-02 3 33402801 33402904 104 - 2.516 2.536 0.068
ENSG00000153560 E023 132.1835745 0.0013331322 2.042687e-01 3.315009e-01 3 33408690 33408797 108 - 2.081 2.110 0.096
ENSG00000153560 E024 257.5277140 0.0013293362 1.389331e-01 2.466244e-01 3 33409236 33409284 49 - 2.367 2.397 0.099
ENSG00000153560 E025 301.4527024 0.0002301144 1.662276e-02 4.410643e-02 3 33409285 33409346 62 - 2.438 2.460 0.071
ENSG00000153560 E026 429.9715804 0.0001675136 3.998680e-07 3.605435e-06 3 33409449 33409587 139 - 2.604 2.582 -0.074
ENSG00000153560 E027 197.7023232 0.0002038768 1.409431e-04 7.075801e-04 3 33409588 33409601 14 - 2.271 2.240 -0.104
ENSG00000153560 E028 361.0056110 0.0001884642 1.567482e-09 2.242522e-08 3 33411581 33411687 107 - 2.537 2.485 -0.175
ENSG00000153560 E029 173.3585298 0.0004322393 1.015417e-02 2.914353e-02 3 33412722 33412725 4 - 2.207 2.204 -0.009
ENSG00000153560 E030 380.9736618 0.0001491823 7.678371e-15 2.570951e-13 3 33412726 33412827 102 - 2.570 2.485 -0.283
ENSG00000153560 E031 0.0000000       3 33416006 33416100 95 -      
ENSG00000153560 E032 256.0787474 0.0013423553 2.806990e-13 7.489799e-12 3 33416758 33416792 35 - 2.413 2.257 -0.519
ENSG00000153560 E033 263.3769531 0.0001481467 5.319082e-23 4.719832e-21 3 33416793 33416834 42 - 2.431 2.255 -0.589
ENSG00000153560 E034 338.4522447 0.0001909842 3.672855e-27 4.808648e-25 3 33425590 33425741 152 - 2.539 2.368 -0.570
ENSG00000153560 E035 201.6944548 0.0148432666 2.846757e-04 1.317607e-03 3 33439736 33439856 121 - 2.314 2.135 -0.599
ENSG00000153560 E036 104.9928268 0.0279827631 6.379196e-04 2.672848e-03 3 33439857 33439925 69 - 2.047 1.790 -0.864
ENSG00000153560 E037 117.2351578 0.0305325451 3.598996e-06 2.647327e-05 3 33439926 33440333 408 - 2.117 1.725 -1.318
ENSG00000153560 E038 6.6991577 0.0345104646 3.900797e-02 8.921281e-02 3 33440334 33440458 125 - 0.919 0.634 -1.142
ENSG00000153560 E039 0.8921407 0.0132170187 8.505888e-02 1.674998e-01 3 33440459 33440676 218 - 0.333 0.000 -10.405
ENSG00000153560 E040 3.8952097 0.0107481230 1.327836e-01 2.379778e-01 3 33440677 33440923 247 - 0.703 0.506 -0.875
ENSG00000153560 E041 0.4427912 0.1757659895 9.019041e-01 9.415031e-01 3 33440924 33441268 345 - 0.141 0.189 0.503
ENSG00000153560 E042 1.0706228 0.0117337466 9.594283e-01 9.785343e-01 3 33441269 33441526 258 - 0.293 0.322 0.194