ENSG00000153446

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000315997 ENSG00000153446 HEK293_OSMI2_2hA HEK293_TMG_2hB C16orf89 protein_coding protein_coding 0.3219109 0.4680399 0.4406134 0.09718182 0.09131568 -0.08524096 0.01247034 0.0000000 0.00000000 0.00000000 0.00000000 0.0000000 0.1089625 0.0000000 0.00000000 0.00000000   0.01928817 FALSE TRUE
ENST00000472572 ENSG00000153446 HEK293_OSMI2_2hA HEK293_TMG_2hB C16orf89 protein_coding protein_coding 0.3219109 0.4680399 0.4406134 0.09718182 0.09131568 -0.08524096 0.10957038 0.2340795 0.01533575 0.07135783 0.01533575 -3.2681046 0.4361000 0.5759667 0.05613333 -0.51983333 0.20551149 0.01928817 FALSE TRUE
ENST00000586629 ENSG00000153446 HEK293_OSMI2_2hA HEK293_TMG_2hB C16orf89 protein_coding retained_intron 0.3219109 0.4680399 0.4406134 0.09718182 0.09131568 -0.08524096 0.04964039 0.0588371 0.09854033 0.05883710 0.05694939 0.6569729 0.1161750 0.1596667 0.19840000 0.03873333 0.77763727 0.01928817 FALSE TRUE
ENST00000591875 ENSG00000153446 HEK293_OSMI2_2hA HEK293_TMG_2hB C16orf89 protein_coding retained_intron 0.3219109 0.4680399 0.4406134 0.09718182 0.09131568 -0.08524096 0.05311895 0.0000000 0.18542538 0.00000000 0.06103561 4.2885459 0.1492625 0.0000000 0.50493333 0.50493333 0.01928817 0.01928817 FALSE TRUE
ENST00000592343 ENSG00000153446 HEK293_OSMI2_2hA HEK293_TMG_2hB C16orf89 protein_coding retained_intron 0.3219109 0.4680399 0.4406134 0.09718182 0.09131568 -0.08524096 0.09711085 0.1751233 0.14131191 0.17512332 0.14131191 -0.2909611 0.1895000 0.2643667 0.24053333 -0.02383333 1.00000000 0.01928817 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153446 E001 2.6977678 0.009606654 0.56237837 0.68999273 16 5044122 5044478 357 - 0.457 0.506 0.244
ENSG00000153446 E002 0.0000000       16 5044479 5044836 358 -      
ENSG00000153446 E003 2.0690189 0.008431020 0.13136208 0.23604431 16 5047878 5047964 87 - 0.210 0.458 1.589
ENSG00000153446 E004 2.1597893 0.105290194 0.47604531 0.61473529 16 5055246 5055350 105 - 0.351 0.435 0.473
ENSG00000153446 E005 0.0000000       16 5055351 5055377 27 -      
ENSG00000153446 E006 0.0000000       16 5055687 5055782 96 -      
ENSG00000153446 E007 2.5618075 0.105029378 0.63677624 0.75073806 16 5056053 5056188 136 - 0.457 0.483 0.131
ENSG00000153446 E008 2.4292941 0.008431669 0.31835010 0.46131878 16 5058493 5058610 118 - 0.351 0.483 0.716
ENSG00000153446 E009 0.0000000       16 5058611 5058620 10 -      
ENSG00000153446 E010 0.1451727 0.050027695 0.15032766   16 5060224 5060285 62 - 0.210 0.000 -11.057
ENSG00000153446 E011 1.7263490 0.009026742 0.22602977 0.35763532 16 5060286 5060436 151 - 0.210 0.403 1.300
ENSG00000153446 E012 1.4058172 0.014517717 0.17330370 0.29249661 16 5062425 5062574 150 - 0.543 0.267 -1.551
ENSG00000153446 E013 1.9699349 0.371685871 0.03372447 0.07920509 16 5065701 5066110 410 - 0.778 0.257 -2.628