ENSG00000153443

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000283474 ENSG00000153443 HEK293_OSMI2_2hA HEK293_TMG_2hB UBALD1 protein_coding protein_coding 40.36701 73.79033 27.65228 4.520874 0.8291282 -1.415707 28.879398 57.5875283 18.400317 2.4085207 0.85667653 -1.6454924 0.68465000 0.78233333 0.66490000 -0.11743333 4.613979e-03 1.765858e-06 FALSE FALSE
ENST00000587649 ENSG00000153443 HEK293_OSMI2_2hA HEK293_TMG_2hB UBALD1 protein_coding protein_coding 40.36701 73.79033 27.65228 4.520874 0.8291282 -1.415707 1.300649 0.9063618 1.787121 0.2749021 0.13311265 0.9716983 0.03776667 0.01216667 0.06453333 0.05236667 1.765858e-06 1.765858e-06 FALSE FALSE
ENST00000590891 ENSG00000153443 HEK293_OSMI2_2hA HEK293_TMG_2hB UBALD1 protein_coding protein_coding 40.36701 73.79033 27.65228 4.520874 0.8291282 -1.415707 6.049647 7.6556165 3.960983 0.5019649 0.06266252 -0.9489057 0.17236250 0.10380000 0.14343333 0.03963333 9.915556e-03 1.765858e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153443 E001 1.213603 0.0110751127 8.261601e-01 8.905972e-01 16 4608883 4608883 1 - 0.324 0.291 -0.212
ENSG00000153443 E002 85.345559 0.0027501399 4.766903e-03 1.528083e-02 16 4608884 4609052 169 - 1.720 1.891 0.576
ENSG00000153443 E003 648.829836 0.0037963408 7.557982e-04 3.100219e-03 16 4609053 4609367 315 - 2.634 2.757 0.409
ENSG00000153443 E004 921.592889 0.0017274390 6.347482e-04 2.661306e-03 16 4609368 4609720 353 - 2.812 2.902 0.301
ENSG00000153443 E005 318.261906 0.0003240025 2.976044e-01 4.389588e-01 16 4609721 4609830 110 - 2.385 2.428 0.146
ENSG00000153443 E006 271.353345 0.0012576462 6.973275e-01 7.974658e-01 16 4609831 4609908 78 - 2.326 2.358 0.105
ENSG00000153443 E007 249.055903 0.0019633589 1.641333e-01 2.805406e-01 16 4609909 4609983 75 - 2.335 2.311 -0.082
ENSG00000153443 E008 88.097199 0.0038841681 2.062269e-02 5.279190e-02 16 4609984 4610492 509 - 1.944 1.847 -0.327
ENSG00000153443 E009 277.208152 0.0031196001 3.573011e-01 5.017019e-01 16 4610493 4610555 63 - 2.370 2.360 -0.036
ENSG00000153443 E010 52.919004 0.0004677465 8.716962e-02 1.708553e-01 16 4610556 4610656 101 - 1.706 1.630 -0.257
ENSG00000153443 E011 209.702342 0.0002931738 5.031965e-11 9.348737e-10 16 4610657 4611523 867 - 2.357 2.197 -0.534
ENSG00000153443 E012 39.408780 0.0199286146 3.093100e-08 3.470203e-07 16 4613960 4614492 533 - 1.837 1.370 -1.594
ENSG00000153443 E013 16.776307 0.0025449000 4.481085e-13 1.163712e-11 16 4614493 4614677 185 - 1.548 0.956 -2.095
ENSG00000153443 E014 244.238279 0.0029213702 1.504877e-01 2.623513e-01 16 4614678 4614764 87 - 2.330 2.300 -0.099
ENSG00000153443 E015 182.221403 0.0008489983 3.165634e-02 7.518020e-02 16 4614765 4614888 124 - 2.217 2.167 -0.168
ENSG00000153443 E016 7.801893 0.0022476048 3.996351e-01 5.433800e-01 16 4614917 4615027 111 - 0.942 0.852 -0.342