ENSG00000153395

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000283415 ENSG00000153395 HEK293_OSMI2_2hA HEK293_TMG_2hB LPCAT1 protein_coding protein_coding 67.18207 76.53162 58.99947 0.2732698 0.4163299 -0.375298 52.69438 44.91127 55.7711778 3.811504 0.3305441 0.3123797 0.8022542 0.5872 0.94543333 0.3582333 3.338244e-11 3.338244e-11 FALSE TRUE
ENST00000503252 ENSG00000153395 HEK293_OSMI2_2hA HEK293_TMG_2hB LPCAT1 protein_coding processed_transcript 67.18207 76.53162 58.99947 0.2732698 0.4163299 -0.375298 12.66186 30.95922 0.9899683 4.001874 0.4972867 -4.9528090 0.1692542 0.4042 0.01673333 -0.3874667 1.175815e-02 3.338244e-11 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153395 E001 0.7341688 0.2706940096 3.705027e-02 8.556599e-02 5 1456480 1458091 1612 - 0.422 0.000 -11.622
ENSG00000153395 E002 0.1515154 0.0426792141 4.096011e-01   5 1460123 1460378 256 - 0.124 0.000 -11.699
ENSG00000153395 E003 0.4418608 0.0268604671 5.928385e-02 1.254120e-01 5 1461190 1461397 208 - 0.298 0.000 -13.586
ENSG00000153395 E004 1.1113958 0.0116282580 2.743770e-02 6.688270e-02 5 1461427 1461428 2 - 0.473 0.121 -2.614
ENSG00000153395 E005 1055.1642765 0.0094396894 3.752876e-09 5.001204e-08 5 1461429 1461839 411 - 2.796 3.145 1.161
ENSG00000153395 E006 4047.9434947 0.0011602225 6.454257e-19 3.634779e-17 5 1461840 1463835 1996 - 3.499 3.675 0.587
ENSG00000153395 E007 583.3744555 0.0021552009 2.013889e-04 9.697166e-04 5 1466749 1466890 142 - 2.775 2.753 -0.071
ENSG00000153395 E008 16.2805968 0.0165565168 5.434854e-01 6.740967e-01 5 1467181 1467338 158 - 1.151 1.283 0.469
ENSG00000153395 E009 439.1664382 0.0006331719 1.810910e-06 1.422411e-05 5 1470826 1470924 99 - 2.652 2.630 -0.073
ENSG00000153395 E010 589.0980631 0.0002222336 8.799458e-09 1.095938e-07 5 1473957 1474110 154 - 2.776 2.761 -0.051
ENSG00000153395 E011 469.5187187 0.0010109909 8.704088e-06 5.863599e-05 5 1474560 1474685 126 - 2.681 2.659 -0.075
ENSG00000153395 E012 424.9714441 0.0016465618 1.388437e-04 6.985399e-04 5 1477404 1477486 83 - 2.638 2.615 -0.075
ENSG00000153395 E013 8.7321229 0.0056641511 6.504233e-04 2.717525e-03 5 1479476 1479620 145 - 1.130 0.811 -1.191
ENSG00000153395 E014 382.0675546 0.0012009229 9.792078e-05 5.122832e-04 5 1479621 1479675 55 - 2.590 2.570 -0.065
ENSG00000153395 E015 308.7294219 0.0002040412 2.188388e-07 2.082078e-06 5 1480942 1480976 35 - 2.506 2.473 -0.110
ENSG00000153395 E016 335.6818525 0.0004403079 5.246002e-08 5.631776e-07 5 1483428 1483486 59 - 2.546 2.505 -0.138
ENSG00000153395 E017 1.1468953 0.0112328003 5.307787e-01 6.633141e-01 5 1488377 1488390 14 - 0.365 0.294 -0.445
ENSG00000153395 E018 290.4877084 0.0002210811 1.249869e-06 1.017025e-05 5 1488391 1488451 61 - 2.477 2.447 -0.098
ENSG00000153395 E019 352.0262602 0.0022452453 2.103214e-07 2.007697e-06 5 1489746 1489858 113 - 2.585 2.507 -0.258
ENSG00000153395 E020 394.8615584 0.0032294892 1.238670e-09 1.802876e-08 5 1494700 1494914 215 - 2.657 2.536 -0.402
ENSG00000153395 E021 0.2214452 0.0401523899 5.757059e-01   5 1494915 1494928 14 - 0.000 0.122 11.161
ENSG00000153395 E022 261.7776130 0.0051177741 8.512780e-12 1.793905e-10 5 1501461 1501603 143 - 2.517 2.314 -0.678
ENSG00000153395 E023 0.6998377 0.0164528559 8.495664e-01 9.066453e-01 5 1521347 1521480 134 - 0.220 0.216 -0.029
ENSG00000153395 E024 149.9087473 0.0061862479 6.797583e-20 4.258537e-18 5 1523710 1523963 254 - 2.341 1.971 -1.237