ENSG00000153363

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000423222 ENSG00000153363 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00467 lncRNA lncRNA 8.275195 6.099993 16.13856 1.116231 1.196886 1.402163 1.1265410 1.0675445 1.4952344 0.1792644 0.1418721 0.4822406 0.16490833 0.17860000 0.09366667 -0.08493333 0.0282779520 0.0003481944 FALSE TRUE
ENST00000653498 ENSG00000153363 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00467 lncRNA lncRNA 8.275195 6.099993 16.13856 1.116231 1.196886 1.402163 0.9230520 0.6880162 2.6365247 0.3843934 0.6543804 1.9227667 0.10046250 0.10776667 0.15993333 0.05216667 0.6914776625 0.0003481944 TRUE FALSE
ENST00000656082 ENSG00000153363 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00467 lncRNA lncRNA 8.275195 6.099993 16.13856 1.116231 1.196886 1.402163 0.3106983 0.4495734 0.5249304 0.3101120 0.5249304 0.2190558 0.03516250 0.09136667 0.03816667 -0.05320000 0.5590309487 0.0003481944 TRUE FALSE
ENST00000662549 ENSG00000153363 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00467 lncRNA lncRNA 8.275195 6.099993 16.13856 1.116231 1.196886 1.402163 0.5579914 0.3593515 1.1939613 0.2125699 0.3261635 1.7047228 0.05718333 0.05166667 0.07160000 0.01993333 0.7444584330 0.0003481944 FALSE FALSE
ENST00000663427 ENSG00000153363 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00467 lncRNA lncRNA 8.275195 6.099993 16.13856 1.116231 1.196886 1.402163 0.2542127 0.3941002 0.2285668 0.3069864 0.2285668 -0.7603198 0.05552500 0.08303333 0.01663333 -0.06640000 0.5630591932 0.0003481944 TRUE FALSE
ENST00000664255 ENSG00000153363 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00467 lncRNA lncRNA 8.275195 6.099993 16.13856 1.116231 1.196886 1.402163 0.3997548 0.6876828 0.3512411 0.1159712 0.1092983 -0.9496091 0.06912083 0.11380000 0.02233333 -0.09146667 0.0003481944 0.0003481944 FALSE FALSE
ENST00000669618 ENSG00000153363 HEK293_OSMI2_2hA HEK293_TMG_2hB LINC00467 lncRNA lncRNA 8.275195 6.099993 16.13856 1.116231 1.196886 1.402163 4.3066500 1.9944545 9.2574720 1.0266298 1.1976124 2.2089662 0.45126667 0.28926667 0.56860000 0.27933333 0.5758168619 0.0003481944   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153363 E001 0.0000000       1 211382736 211382756 21 +      
ENSG00000153363 E002 0.0000000       1 211382757 211382761 5 +      
ENSG00000153363 E003 0.2214452 0.0565841678 2.536993e-01   1 211382762 211382766 5 + 0.000 0.162 11.568
ENSG00000153363 E004 0.2214452 0.0565841678 2.536993e-01   1 211382767 211382771 5 + 0.000 0.162 13.669
ENSG00000153363 E005 0.2214452 0.0565841678 2.536993e-01   1 211382772 211382774 3 + 0.000 0.162 13.669
ENSG00000153363 E006 0.2214452 0.0565841678 2.536993e-01   1 211382775 211382776 2 + 0.000 0.162 13.669
ENSG00000153363 E007 1.3275425 0.0112395654 8.564367e-01 9.112263e-01 1 211382777 211382789 13 + 0.337 0.372 0.207
ENSG00000153363 E008 1.6242306 0.0086573578 7.699037e-01 8.514352e-01 1 211382790 211382792 3 + 0.422 0.372 -0.278
ENSG00000153363 E009 1.6242306 0.0086573578 7.699037e-01 8.514352e-01 1 211382793 211382793 1 + 0.422 0.372 -0.278
ENSG00000153363 E010 2.1046994 0.0067422174 7.838126e-01 8.613014e-01 1 211382794 211382799 6 + 0.493 0.448 -0.226
ENSG00000153363 E011 2.2529926 0.0066537530 9.211523e-01 9.542349e-01 1 211382800 211382802 3 + 0.493 0.513 0.095
ENSG00000153363 E012 3.9428124 0.0040467011 5.713257e-01 6.976302e-01 1 211382803 211382807 5 + 0.655 0.741 0.357
ENSG00000153363 E013 10.9879855 0.0016208636 5.967299e-01 7.186322e-01 1 211382808 211382816 9 + 1.089 1.038 -0.183
ENSG00000153363 E014 17.2807688 0.0068279078 1.318751e-01 2.367259e-01 1 211382817 211382826 10 + 1.301 1.162 -0.490
ENSG00000153363 E015 22.5186654 0.0036094829 9.718651e-01 9.864324e-01 1 211382827 211382829 3 + 1.363 1.363 0.002
ENSG00000153363 E016 29.1087536 0.0007556787 5.635666e-01 6.910157e-01 1 211382830 211382836 7 + 1.482 1.448 -0.116
ENSG00000153363 E017 64.6831748 0.0028039853 2.863933e-01 4.267786e-01 1 211382837 211382909 73 + 1.827 1.778 -0.167
ENSG00000153363 E018 53.0761086 0.0011813754 1.089229e-01 2.039437e-01 1 211382910 211382925 16 + 1.753 1.676 -0.261
ENSG00000153363 E019 0.0000000       1 211382926 211382975 50 +      
ENSG00000153363 E020 0.8868276 0.0668118057 7.835414e-01 8.610933e-01 1 211384442 211384534 93 + 0.232 0.281 0.371
ENSG00000153363 E021 0.0000000       1 211390564 211390670 107 +      
ENSG00000153363 E022 93.9287018 0.0003398480 1.879869e-01 3.111821e-01 1 211391616 211391697 82 + 1.988 1.945 -0.145
ENSG00000153363 E023 113.2724951 0.0002844270 1.936107e-01 3.183248e-01 1 211391827 211391910 84 + 2.067 2.029 -0.127
ENSG00000153363 E024 88.5887602 0.0016320416 6.237538e-01 7.402451e-01 1 211391911 211391949 39 + 1.937 1.959 0.074
ENSG00000153363 E025 86.9846972 0.0027915132 8.163795e-01 8.838104e-01 1 211391950 211391976 27 + 1.942 1.933 -0.028
ENSG00000153363 E026 3.8104404 0.0060588714 8.836513e-01 9.295842e-01 1 211394952 211395001 50 + 0.677 0.704 0.110
ENSG00000153363 E027 89.9242497 0.0061235229 2.803841e-01 4.202471e-01 1 211396767 211396831 65 + 1.973 1.915 -0.195
ENSG00000153363 E028 0.2214452 0.0565841678 2.536993e-01   1 211396832 211396841 10 + 0.000 0.162 13.669
ENSG00000153363 E029 0.5911836 0.1026901263 2.740946e-02 6.682246e-02 1 211396842 211397513 672 + 0.000 0.374 15.022
ENSG00000153363 E030 13.4858883 0.0077368865 1.391364e-10 2.397579e-09 1 211398036 211399219 1184 + 0.790 1.439 2.358
ENSG00000153363 E031 0.0000000       1 211399258 211399376 119 +      
ENSG00000153363 E032 0.4375944 0.0261994352 2.497662e-01 3.856424e-01 1 211399377 211399437 61 + 0.231 0.000 -14.425
ENSG00000153363 E033 0.1482932 0.0411597534 2.569415e-01   1 211408201 211408439 239 + 0.000 0.161 13.738
ENSG00000153363 E034 0.6934950 0.1419052166 5.056377e-01 6.413854e-01 1 211422539 211422639 101 + 0.167 0.282 0.961
ENSG00000153363 E035 0.3268771 0.0318549781 6.307011e-01   1 211422640 211422670 31 + 0.092 0.162 0.944
ENSG00000153363 E036 0.0000000       1 211422671 211422700 30 +      
ENSG00000153363 E037 73.6342770 0.0016836309 2.761326e-01 4.155413e-01 1 211426211 211426283 73 + 1.885 1.841 -0.150
ENSG00000153363 E038 0.0000000       1 211428417 211428575 159 +      
ENSG00000153363 E039 0.1482932 0.0411597534 2.569415e-01   1 211432046 211432290 245 + 0.000 0.161 13.738
ENSG00000153363 E040 39.3356281 0.0005501910 7.469329e-01 8.345843e-01 1 211432319 211432320 2 + 1.591 1.614 0.078
ENSG00000153363 E041 101.7550450 0.0003324039 3.911925e-01 5.351306e-01 1 211432321 211433225 905 + 1.993 2.027 0.115
ENSG00000153363 E042 25.4075903 0.0047331031 4.190333e-01 5.622855e-01 1 211433226 211434088 863 + 1.389 1.454 0.227
ENSG00000153363 E043 43.2151012 0.0075846591 7.063506e-05 3.831854e-04 1 211434089 211435333 1245 + 1.517 1.785 0.909
ENSG00000153363 E044 1.4727151 0.0112279946 9.480215e-01 9.713350e-01 1 211435355 211435570 216 + 0.382 0.372 -0.056