ENSG00000153339

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000283351 ENSG00000153339 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC8 protein_coding protein_coding 17.52133 4.159348 29.78482 0.07617057 2.028145 2.837168 2.1802439 0.7021481 4.1763264 0.1837840 0.2954855 2.5554356 0.14427500 0.1688333 0.1403000 -0.02853333 8.516338e-01 4.733699e-12 FALSE TRUE
ENST00000580104 ENSG00000153339 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC8 protein_coding nonsense_mediated_decay 17.52133 4.159348 29.78482 0.07617057 2.028145 2.837168 2.3653132 1.0000159 3.4868919 0.1265484 0.3408805 1.7916953 0.16430417 0.2398333 0.1189333 -0.12090000 2.858120e-02 4.733699e-12 TRUE TRUE
ENST00000581057 ENSG00000153339 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC8 protein_coding protein_coding 17.52133 4.159348 29.78482 0.07617057 2.028145 2.837168 0.2651621 0.4145046 0.2797191 0.2549950 0.1694562 -0.5511254 0.03574167 0.1007333 0.0096000 -0.09113333 4.999912e-01 4.733699e-12   FALSE
ENST00000582509 ENSG00000153339 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC8 protein_coding processed_transcript 17.52133 4.159348 29.78482 0.07617057 2.028145 2.837168 2.9059476 1.3276239 4.4802693 0.2853665 1.1768055 1.7471295 0.23775000 0.3205000 0.1472333 -0.17326667 1.081828e-01 4.733699e-12   FALSE
ENST00000582539 ENSG00000153339 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC8 protein_coding protein_coding 17.52133 4.159348 29.78482 0.07617057 2.028145 2.837168 5.6918074 0.6163362 9.4372325 0.3082873 0.8925454 3.9148826 0.25431250 0.1460667 0.3198000 0.17373333 5.386084e-01 4.733699e-12 FALSE TRUE
MSTRG.15652.5 ENSG00000153339 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC8 protein_coding   17.52133 4.159348 29.78482 0.07617057 2.028145 2.837168 1.1068482 0.0278673 2.0405770 0.0278673 0.5082901 5.7589335 0.03926250 0.0065000 0.0669000 0.06040000 2.046680e-03 4.733699e-12 FALSE TRUE
MSTRG.15652.7 ENSG00000153339 HEK293_OSMI2_2hA HEK293_TMG_2hB TRAPPC8 protein_coding   17.52133 4.159348 29.78482 0.07617057 2.028145 2.837168 2.2479496 0.0000000 4.6546691 0.0000000 0.3324642 8.8656309 0.07995000 0.0000000 0.1586667 0.15866667 4.733699e-12 4.733699e-12 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153339 E001 13.5005723 0.0018497838 4.849054e-04 2.102485e-03 18 31829197 31829937 741 - 0.937 1.318 1.373
ENSG00000153339 E002 177.5718083 0.0053944470 1.034587e-16 4.442416e-15 18 31829938 31830497 560 - 2.010 2.398 1.296
ENSG00000153339 E003 120.8147528 0.0002358141 2.109951e-07 2.013824e-06 18 31830498 31830589 92 - 1.884 2.104 0.740
ENSG00000153339 E004 63.8649926 0.0003789076 1.872888e-04 9.092640e-04 18 31830590 31830594 5 - 1.613 1.830 0.737
ENSG00000153339 E005 64.9504674 0.0004216528 5.823767e-04 2.468664e-03 18 31830595 31830597 3 - 1.624 1.824 0.680
ENSG00000153339 E006 109.7333214 0.0003441142 3.852316e-05 2.229448e-04 18 31830598 31830691 94 - 1.850 2.038 0.629
ENSG00000153339 E007 177.8459768 0.0002560294 1.056685e-09 1.559713e-08 18 31830692 31830920 229 - 2.052 2.267 0.718
ENSG00000153339 E008 98.2856647 0.0003252110 6.344482e-06 4.413067e-05 18 31830921 31830984 64 - 1.798 2.012 0.718
ENSG00000153339 E009 65.9204168 0.0004673094 2.298863e-04 1.091374e-03 18 31830985 31830989 5 - 1.630 1.842 0.717
ENSG00000153339 E010 125.1361042 0.0003782518 9.457397e-05 4.965841e-04 18 31832084 31832173 90 - 1.910 2.079 0.566
ENSG00000153339 E011 3.3076085 0.1159263432 4.783453e-02 1.053280e-01 18 31832174 31832595 422 - 0.441 0.854 1.805
ENSG00000153339 E012 1.9519389 0.1874437167 1.340248e-01 2.397465e-01 18 31833276 31833406 131 - 0.313 0.655 1.733
ENSG00000153339 E013 144.5325802 0.0002451175 3.966172e-05 2.287861e-04 18 31839312 31839457 146 - 1.972 2.137 0.552
ENSG00000153339 E014 78.5890721 0.0003719000 9.213579e-03 2.681896e-02 18 31846716 31846750 35 - 1.715 1.858 0.483
ENSG00000153339 E015 92.5734284 0.0006276767 3.500078e-02 8.165600e-02 18 31846751 31846817 67 - 1.789 1.900 0.373
ENSG00000153339 E016 123.8561743 0.0002509631 3.821127e-02 8.774770e-02 18 31849566 31849739 174 - 1.918 2.012 0.314
ENSG00000153339 E017 73.3428129 0.0010094006 1.221205e-01 2.229550e-01 18 31852446 31852504 59 - 1.695 1.788 0.314
ENSG00000153339 E018 82.0509004 0.0026240931 4.918026e-01 6.290625e-01 18 31852595 31852663 69 - 1.752 1.794 0.143
ENSG00000153339 E019 0.3268771 0.0294089422 1.430861e-01   18 31852664 31852872 209 - 0.048 0.279 2.937
ENSG00000153339 E020 96.0361361 0.0003225060 4.993383e-01 6.356506e-01 18 31853849 31853945 97 - 1.830 1.794 -0.120
ENSG00000153339 E021 109.5445735 0.0030372811 2.043673e-01 3.316183e-01 18 31855660 31855807 148 - 1.892 1.818 -0.249
ENSG00000153339 E022 110.6040794 0.0015007119 3.410338e-01 4.849564e-01 18 31857540 31857720 181 - 1.892 1.842 -0.170
ENSG00000153339 E023 129.2513381 0.0002633251 3.811964e-02 8.757913e-02 18 31857721 31857982 262 - 1.963 1.864 -0.335
ENSG00000153339 E024 107.2109944 0.0006188520 1.553893e-01 2.689167e-01 18 31864627 31864781 155 - 1.881 1.806 -0.251
ENSG00000153339 E025 108.3827135 0.0002869394 2.958523e-01 4.370002e-01 18 31866849 31866975 127 - 1.883 1.830 -0.178
ENSG00000153339 E026 93.5374863 0.0005130336 4.305471e-01 5.731850e-01 18 31867402 31867476 75 - 1.818 1.775 -0.144
ENSG00000153339 E027 0.6017953 0.1580740527 1.000000e+00 1.000000e+00 18 31870014 31870356 343 - 0.168 0.000 -10.072
ENSG00000153339 E028 1.1866387 0.0109118528 3.545054e-01 4.988227e-01 18 31870357 31870371 15 - 0.288 0.000 -11.067
ENSG00000153339 E029 119.6011988 0.0002506135 8.631812e-03 2.536720e-02 18 31870372 31870502 131 - 1.935 1.800 -0.452
ENSG00000153339 E030 127.2849605 0.0002470124 1.922355e-04 9.305848e-04 18 31870926 31871065 140 - 1.967 1.775 -0.646
ENSG00000153339 E031 81.4845110 0.0003394819 3.624944e-03 1.208189e-02 18 31871066 31871120 55 - 1.775 1.589 -0.631
ENSG00000153339 E032 90.6661738 0.0013332678 1.735285e-02 4.571929e-02 18 31873430 31873538 109 - 1.817 1.672 -0.490
ENSG00000153339 E033 0.2934659 0.0299393520 1.433581e-01   18 31873570 31874479 910 - 0.048 0.278 2.934
ENSG00000153339 E034 94.6092656 0.0006657007 5.051073e-04 2.179300e-03 18 31874480 31874704 225 - 1.840 1.628 -0.719
ENSG00000153339 E035 77.4590573 0.0003334674 2.735708e-04 1.272144e-03 18 31890735 31890866 132 - 1.759 1.512 -0.841
ENSG00000153339 E036 0.5933762 0.0203075586 1.000000e+00 1.000000e+00 18 31890867 31891207 341 - 0.167 0.000 -10.067
ENSG00000153339 E037 76.2576556 0.0026261882 1.680080e-01 2.856147e-01 18 31897786 31897891 106 - 1.736 1.646 -0.305
ENSG00000153339 E038 64.2229506 0.0007074995 5.863934e-02 1.242985e-01 18 31900925 31901025 101 - 1.668 1.536 -0.449
ENSG00000153339 E039 82.2380304 0.0003232102 4.811954e-06 3.440044e-05 18 31907460 31907610 151 - 1.789 1.475 -1.071
ENSG00000153339 E040 72.9525091 0.0003561607 3.348734e-07 3.067439e-06 18 31908303 31908418 116 - 1.744 1.354 -1.333
ENSG00000153339 E041 124.6835912 0.0374474107 2.943198e-03 1.009725e-02 18 31908754 31909010 257 - 1.969 1.652 -1.068
ENSG00000153339 E042 3.1861363 0.0549086036 3.191588e-01 4.622021e-01 18 31909011 31909013 3 - 0.525 0.280 -1.380
ENSG00000153339 E043 63.7650890 0.0013466701 3.482582e-02 8.131489e-02 18 31909667 31909760 94 - 1.665 1.513 -0.521
ENSG00000153339 E044 76.5593440 0.0020528732 2.469637e-03 8.673007e-03 18 31913369 31913501 133 - 1.750 1.536 -0.725
ENSG00000153339 E045 43.0463151 0.0101977691 2.521965e-03 8.828247e-03 18 31913502 31913522 21 - 1.514 1.190 -1.129
ENSG00000153339 E046 90.6395042 0.0003215944 1.059002e-07 1.070912e-06 18 31916272 31916446 175 - 1.834 1.475 -1.220
ENSG00000153339 E047 69.8687837 0.0060861109 3.577349e-04 1.609935e-03 18 31917578 31917667 90 - 1.718 1.420 -1.017
ENSG00000153339 E048 0.0000000       18 31926468 31926605 138 -      
ENSG00000153339 E049 86.0345088 0.0005987493 4.616587e-05 2.623665e-04 18 31931329 31931523 195 - 1.805 1.536 -0.914
ENSG00000153339 E050 0.2966881 0.0274424043 1.000000e+00   18 31936339 31936396 58 - 0.092 0.000 -9.067
ENSG00000153339 E051 0.1451727 0.0426668368 7.253861e-01   18 31939381 31939394 14 - 0.048 0.000 -8.067
ENSG00000153339 E052 0.2903454 0.2943426703 1.000000e+00   18 31939395 31939744 350 - 0.091 0.000 -9.063
ENSG00000153339 E053 54.9985994 0.0030887847 1.056708e-06 8.725161e-06 18 31942608 31942893 286 - 1.629 1.162 -1.620
ENSG00000153339 E054 24.9674018 0.0008771380 2.282482e-03 8.097249e-03 18 31942894 31942951 58 - 1.294 0.914 -1.376
ENSG00000153339 E055 46.8202175 0.0149789233 4.540506e-05 2.584769e-04 18 31942952 31943037 86 - 1.560 1.074 -1.703
ENSG00000153339 E056 42.1927990 0.0153621260 1.100513e-04 5.681978e-04 18 31943038 31943114 77 - 1.516 1.039 -1.677
ENSG00000153339 E057 7.2867750 0.0022071155 1.203698e-02 3.362037e-02 18 31943115 31943933 819 - 0.823 0.279 -2.648
ENSG00000153339 E058 0.0000000       18 31953050 31953136 87 -