ENSG00000153291

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000371347 ENSG00000153291 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A27 protein_coding protein_coding 3.370205 1.707387 3.290705 0.2780415 0.4691854 0.9425588 0.6682847 0.5102044 0.71056408 0.05515434 0.18883645 0.47004825 0.2215500 0.30476667 0.21746667 -0.0873000000 0.5445868 0.0396077 FALSE TRUE
ENST00000603486 ENSG00000153291 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A27 protein_coding protein_coding 3.370205 1.707387 3.290705 0.2780415 0.4691854 0.9425588 1.0890758 0.4390177 1.25594260 0.17426441 0.22827284 1.49536773 0.2987625 0.23990000 0.37933333 0.1394333333 0.2432366 0.0396077 FALSE FALSE
ENST00000604217 ENSG00000153291 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A27 protein_coding protein_coding 3.370205 1.707387 3.290705 0.2780415 0.4691854 0.9425588 0.4507433 0.0000000 0.34030403 0.00000000 0.34030403 5.13053567 0.1102333 0.00000000 0.09866667 0.0986666667 0.9217209 0.0396077 FALSE FALSE
ENST00000604616 ENSG00000153291 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A27 protein_coding protein_coding 3.370205 1.707387 3.290705 0.2780415 0.4691854 0.9425588 0.3277483 0.1702332 0.18204475 0.17023324 0.18204475 0.09157744 0.0888750 0.07586667 0.07550000 -0.0003666667 0.9231420 0.0396077 FALSE TRUE
MSTRG.28385.3 ENSG00000153291 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A27 protein_coding   3.370205 1.707387 3.290705 0.2780415 0.4691854 0.9425588 0.2769089 0.3268037 0.44486710 0.19287910 0.28405455 0.43353715 0.1038000 0.22153333 0.11576667 -0.1057666667 0.8736215 0.0396077 FALSE TRUE
MSTRG.28385.4 ENSG00000153291 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC25A27 protein_coding   3.370205 1.707387 3.290705 0.2780415 0.4691854 0.9425588 0.1839229 0.2172667 0.05221374 0.02753376 0.05221374 -1.86908142 0.0727375 0.13426667 0.01513333 -0.1191333333 0.0396077 0.0396077 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153291 E001 0.7061804 0.0228259174 0.7978209309 0.870992521 6 46652915 46652974 60 + 0.198 0.239 0.339
ENSG00000153291 E002 6.6178770 0.0037082365 0.0600435872 0.126676884 6 46652975 46653213 239 + 0.751 0.974 0.861
ENSG00000153291 E003 2.8191971 0.0075607612 0.7900951966 0.865744505 6 46653214 46653233 20 + 0.557 0.594 0.167
ENSG00000153291 E004 4.2854809 0.0041397797 0.5354029104 0.667253080 6 46653234 46653298 65 + 0.678 0.760 0.337
ENSG00000153291 E005 13.5231905 0.0014802552 0.3857409292 0.529926990 6 46655843 46656030 188 + 1.198 1.116 -0.291
ENSG00000153291 E006 5.9620306 0.0627317805 0.0287401791 0.069483674 6 46656031 46656034 4 + 0.987 0.629 -1.416
ENSG00000153291 E007 5.5819978 0.0054407024 0.0005810468 0.002463633 6 46658663 46658752 90 + 0.986 0.505 -1.984
ENSG00000153291 E008 9.1187385 0.0342048315 0.0216449345 0.054937941 6 46658753 46658961 209 + 1.119 0.816 -1.132
ENSG00000153291 E009 11.4462519 0.0020400223 0.8724171637 0.921954525 6 46658962 46659046 85 + 1.100 1.078 -0.078
ENSG00000153291 E010 13.8433966 0.0020047884 0.9577200939 0.977493193 6 46662376 46662459 84 + 1.165 1.163 -0.008
ENSG00000153291 E011 10.6776314 0.0021315025 0.2211680469 0.351825672 6 46662460 46662498 39 + 1.119 0.990 -0.470
ENSG00000153291 E012 15.7471625 0.0012243137 0.7458186069 0.833748135 6 46664774 46664874 101 + 1.236 1.204 -0.113
ENSG00000153291 E013 10.3123913 0.0016654374 0.5467067953 0.676826474 6 46664875 46664886 12 + 1.024 1.078 0.199
ENSG00000153291 E014 12.9016369 0.0015129662 0.5111715209 0.646275843 6 46668709 46668793 85 + 1.119 1.173 0.192
ENSG00000153291 E015 13.6379166 0.0016922439 0.0720415547 0.146726895 6 46670135 46670227 93 + 1.090 1.242 0.542
ENSG00000153291 E016 14.1350956 0.0047037120 0.0421621312 0.095022416 6 46671126 46671228 103 + 1.090 1.267 0.632
ENSG00000153291 E017 5.5925262 0.0032200970 0.7598488133 0.844102404 6 46676383 46676512 130 + 0.832 0.787 -0.177
ENSG00000153291 E018 9.6382417 0.0034452090 0.6437500607 0.756220719 6 46676513 46676646 134 + 1.047 0.990 -0.207
ENSG00000153291 E019 16.8637010 0.0012950382 0.1671431418 0.284483916 6 46676647 46676743 97 + 1.198 1.301 0.364
ENSG00000153291 E020 28.0547051 0.0009006728 0.8058134902 0.876548067 6 46676744 46677610 867 + 1.455 1.465 0.034
ENSG00000153291 E021 12.7710827 0.0235632119 0.8129951298 0.881415857 6 46677611 46678190 580 + 1.110 1.146 0.129