ENSG00000153250

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000348849 ENSG00000153250 HEK293_OSMI2_2hA HEK293_TMG_2hB RBMS1 protein_coding protein_coding 11.32569 5.697889 20.46035 0.4121349 0.6158816 1.842507 7.5053721 4.7505757 12.751330 0.53649596 0.4334468 1.422571 0.72000417 0.82930000 0.62350000 -0.20580000 0.001348381 0.0008275102 FALSE TRUE
ENST00000409289 ENSG00000153250 HEK293_OSMI2_2hA HEK293_TMG_2hB RBMS1 protein_coding protein_coding 11.32569 5.697889 20.46035 0.4121349 0.6158816 1.842507 0.8877738 0.0000000 1.043415 0.00000000 1.0434152 6.718930 0.05415833 0.00000000 0.04883333 0.04883333 1.000000000 0.0008275102 FALSE TRUE
ENST00000409972 ENSG00000153250 HEK293_OSMI2_2hA HEK293_TMG_2hB RBMS1 protein_coding protein_coding 11.32569 5.697889 20.46035 0.4121349 0.6158816 1.842507 1.5071656 0.4309163 3.699637 0.04713594 0.7026801 3.072701 0.10929583 0.07693333 0.18283333 0.10590000 0.091761364 0.0008275102 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153250 E001 716.7222175 0.0010681274 2.018641e-36 5.432180e-34 2 160272151 160274414 2264 - 2.736 2.954 0.725
ENSG00000153250 E002 45.3289007 0.0006056286 2.374752e-04 1.122843e-03 2 160274415 160274459 45 - 1.542 1.777 0.799
ENSG00000153250 E003 20.5733928 0.0013003896 7.066157e-06 4.861499e-05 2 160274460 160274479 20 - 1.150 1.531 1.327
ENSG00000153250 E004 15.3711675 0.0159932846 1.355332e-03 5.160717e-03 2 160274480 160274489 10 - 1.030 1.392 1.283
ENSG00000153250 E005 17.9103288 0.0136232240 1.200196e-02 3.353592e-02 2 160274490 160274517 28 - 1.128 1.403 0.969
ENSG00000153250 E006 12.7108527 0.0017119949 2.041348e-01 3.313433e-01 2 160274518 160274519 2 - 1.037 1.196 0.573
ENSG00000153250 E007 14.7306425 0.0012895258 2.064181e-02 5.283071e-02 2 160274520 160274539 20 - 1.065 1.310 0.872
ENSG00000153250 E008 67.3781874 0.0004601786 9.696928e-01 9.850261e-01 2 160274540 160274764 225 - 1.774 1.810 0.121
ENSG00000153250 E009 0.6256415 0.0175767881 1.000000e+00 1.000000e+00 2 160275399 160275629 231 - 0.187 0.201 0.126
ENSG00000153250 E010 61.2534125 0.0004739135 7.477884e-05 4.031482e-04 2 160275630 160275714 85 - 1.787 1.607 -0.612
ENSG00000153250 E011 0.1515154 0.0431096009 1.000000e+00   2 160276642 160276685 44 - 0.072 0.000 -9.288
ENSG00000153250 E012 75.7039365 0.0036787782 4.700926e-04 2.045656e-03 2 160277303 160277383 81 - 1.874 1.712 -0.546
ENSG00000153250 E013 4.1812913 0.0039683505 2.150178e-03 7.690684e-03 2 160277384 160278547 1164 - 0.768 0.201 -3.045
ENSG00000153250 E014 85.4100804 0.0003122538 6.037840e-04 2.546984e-03 2 160278548 160278658 111 - 1.916 1.798 -0.399
ENSG00000153250 E015 1.4706414 0.0096241135 3.390159e-02 7.955329e-02 2 160278659 160279766 1108 - 0.447 0.000 -12.910
ENSG00000153250 E016 67.0881620 0.0003826955 6.982139e-03 2.117699e-02 2 160281314 160281364 51 - 1.808 1.708 -0.340
ENSG00000153250 E017 2.4982761 0.0385865722 4.979329e-02 1.087951e-01 2 160281365 160282256 892 - 0.588 0.201 -2.291
ENSG00000153250 E018 12.1874906 0.0014252318 7.327729e-02 1.487574e-01 2 160282257 160282304 48 - 1.110 0.937 -0.633
ENSG00000153250 E019 5.6218575 0.0028343258 6.618345e-06 4.583366e-05 2 160282305 160284260 1956 - 0.894 0.000 -14.756
ENSG00000153250 E020 2.0660940 0.0070623260 9.339597e-03 2.713116e-02 2 160284261 160284774 514 - 0.546 0.000 -13.394
ENSG00000153250 E021 80.2484075 0.0003781100 4.437524e-04 1.942771e-03 2 160284775 160284868 94 - 1.889 1.760 -0.436
ENSG00000153250 E022 76.4631841 0.0006066035 1.785615e-04 8.717869e-04 2 160284995 160285044 50 - 1.875 1.727 -0.497
ENSG00000153250 E023 27.5640491 0.0006909850 1.403095e-02 3.829485e-02 2 160286969 160286977 9 - 1.444 1.284 -0.555
ENSG00000153250 E024 88.2998387 0.0012965928 1.170466e-04 6.002418e-04 2 160286978 160287084 107 - 1.937 1.789 -0.496
ENSG00000153250 E025 79.0307657 0.0004282157 3.744284e-05 2.173633e-04 2 160300651 160300730 80 - 1.893 1.732 -0.543
ENSG00000153250 E026 0.1451727 0.0436285273 1.000000e+00   2 160302504 160302824 321 - 0.072 0.000 -9.281
ENSG00000153250 E027 66.9549050 0.0003608363 1.295671e-06 1.050505e-05 2 160303330 160303407 78 - 1.833 1.613 -0.746
ENSG00000153250 E028 64.0515258 0.0003663917 2.819451e-05 1.687742e-04 2 160303408 160303487 80 - 1.807 1.619 -0.637
ENSG00000153250 E029 55.2347302 0.0004563041 3.137211e-02 7.462773e-02 2 160313156 160313247 92 - 1.721 1.637 -0.285
ENSG00000153250 E030 51.5230537 0.0004622914 1.236594e-02 3.441288e-02 2 160318169 160318227 59 - 1.697 1.587 -0.372
ENSG00000153250 E031 0.0000000       2 160366913 160367215 303 -      
ENSG00000153250 E032 58.7888703 0.0004079883 3.433183e-03 1.153284e-02 2 160367216 160367388 173 - 1.755 1.631 -0.421
ENSG00000153250 E033 12.4456374 0.0110984844 6.826675e-03 2.077279e-02 2 160367389 160367391 3 - 1.150 0.837 -1.163
ENSG00000153250 E034 0.1472490 0.0439112764 1.000000e+00   2 160401968 160402102 135 - 0.072 0.000 -9.278
ENSG00000153250 E035 17.1146171 0.0011804283 2.981494e-03 1.020885e-02 2 160407464 160407809 346 - 1.266 0.993 -0.983
ENSG00000153250 E036 5.4133412 0.0736244988 8.745031e-01 9.233073e-01 2 160407810 160407889 80 - 0.767 0.757 -0.042
ENSG00000153250 E037 0.0000000       2 160408509 160408609 101 -      
ENSG00000153250 E038 0.0000000       2 160416138 160416178 41 -      
ENSG00000153250 E039 0.7406253 0.0154303000 1.940780e-01 3.189084e-01 2 160432368 160432477 110 - 0.279 0.000 -11.888
ENSG00000153250 E040 0.0000000       2 160492887 160492969 83 -      
ENSG00000153250 E041 22.0804631 0.0008298189 4.642876e-03 1.493926e-02 2 160493289 160493807 519 - 1.364 1.145 -0.773