ENSG00000153208

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295408 ENSG00000153208 HEK293_OSMI2_2hA HEK293_TMG_2hB MERTK protein_coding protein_coding 5.961494 4.220213 7.938354 0.5554711 0.8060636 0.9099258 0.6912326 1.5158105 1.250567 0.5142106 0.6378876 -0.2755026 0.1552250 0.4065667 0.1724000 -0.23416667 6.626653e-01 8.428789e-06 FALSE TRUE
ENST00000421804 ENSG00000153208 HEK293_OSMI2_2hA HEK293_TMG_2hB MERTK protein_coding protein_coding 5.961494 4.220213 7.938354 0.5554711 0.8060636 0.9099258 0.9371535 0.0000000 0.000000 0.0000000 0.0000000 0.0000000 0.1864875 0.0000000 0.0000000 0.00000000   8.428789e-06 TRUE TRUE
ENST00000439966 ENSG00000153208 HEK293_OSMI2_2hA HEK293_TMG_2hB MERTK protein_coding nonsense_mediated_decay 5.961494 4.220213 7.938354 0.5554711 0.8060636 0.9099258 0.8598195 0.8890977 1.059687 0.2140199 0.5630985 0.2506383 0.1724500 0.2038000 0.1407000 -0.06310000 7.806459e-01 8.428789e-06 FALSE TRUE
ENST00000449344 ENSG00000153208 HEK293_OSMI2_2hA HEK293_TMG_2hB MERTK protein_coding protein_coding 5.961494 4.220213 7.938354 0.5554711 0.8060636 0.9099258 1.0618052 1.0367003 1.471797 0.6298823 0.7361899 0.5014993 0.1475417 0.2138333 0.1684000 -0.04543333 9.928986e-01 8.428789e-06 FALSE TRUE
MSTRG.19038.3 ENSG00000153208 HEK293_OSMI2_2hA HEK293_TMG_2hB MERTK protein_coding   5.961494 4.220213 7.938354 0.5554711 0.8060636 0.9099258 2.3803165 0.7352343 4.115406 0.2308701 0.6434149 2.4687703 0.3311625 0.1661333 0.5120667 0.34593333 8.428789e-06 8.428789e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153208 E001 1.7046703 0.0083070212 4.285419e-01 5.712776e-01 2 111898607 111898607 1 + 0.489 0.346 -0.771
ENSG00000153208 E002 1.8519193 0.0074884816 3.188238e-01 4.618107e-01 2 111898608 111898614 7 + 0.524 0.346 -0.941
ENSG00000153208 E003 6.0903532 0.0061184159 4.569978e-03 1.473799e-02 2 111898615 111898628 14 + 0.982 0.585 -1.593
ENSG00000153208 E004 9.1389497 0.0197041400 6.370971e-02 1.328770e-01 2 111898629 111898663 35 + 1.095 0.851 -0.909
ENSG00000153208 E005 16.5925110 0.0735098242 8.213305e-02 1.628878e-01 2 111898664 111898796 133 + 1.339 1.077 -0.928
ENSG00000153208 E006 33.8212424 0.0269747680 6.464835e-02 1.344601e-01 2 111929120 111929304 185 + 1.609 1.422 -0.640
ENSG00000153208 E007 43.4594434 0.0122423759 1.084018e-01 2.031777e-01 2 111929305 111929540 236 + 1.692 1.564 -0.434
ENSG00000153208 E008 32.0364708 0.0007148911 1.172038e-02 3.286595e-02 2 111944960 111945060 101 + 1.576 1.412 -0.564
ENSG00000153208 E009 39.0974303 0.0066062187 4.105217e-03 1.343818e-02 2 111947394 111947567 174 + 1.678 1.475 -0.693
ENSG00000153208 E010 28.5264340 0.0007313963 1.198276e-03 4.634555e-03 2 111965191 111965277 87 + 1.552 1.329 -0.767
ENSG00000153208 E011 32.5081848 0.0006052517 5.896002e-04 2.495375e-03 2 111968137 111968252 116 + 1.605 1.384 -0.761
ENSG00000153208 E012 41.9981372 0.0005513614 1.346061e-02 3.699027e-02 2 111975289 111975472 184 + 1.682 1.541 -0.480
ENSG00000153208 E013 37.3757411 0.0005836367 4.154064e-01 5.588002e-01 2 111982842 111982993 152 + 1.603 1.551 -0.175
ENSG00000153208 E014 34.5738925 0.0009755624 7.951209e-01 8.691200e-01 2 111994251 111994404 154 + 1.552 1.531 -0.070
ENSG00000153208 E015 23.1405370 0.0007877088 4.328495e-01 5.753116e-01 2 111997323 111997369 47 + 1.354 1.405 0.177
ENSG00000153208 E016 34.8795784 0.0006152033 6.239201e-01 7.403821e-01 2 111997370 111997476 107 + 1.542 1.566 0.081
ENSG00000153208 E017 33.8384827 0.0009510760 4.715946e-01 6.106913e-01 2 112001201 112001286 86 + 1.558 1.510 -0.165
ENSG00000153208 E018 38.3246075 0.0005535504 9.560000e-01 9.764256e-01 2 112003092 112003187 96 + 1.591 1.589 -0.006
ENSG00000153208 E019 0.5169874 0.0200360089 3.348095e-01 4.785444e-01 2 112003188 112003443 256 + 0.100 0.259 1.645
ENSG00000153208 E020 40.9895524 0.0006352526 6.976347e-01 7.977244e-01 2 112003904 112003984 81 + 1.608 1.624 0.055
ENSG00000153208 E021 44.3191006 0.0005271116 9.931305e-01 9.998384e-01 2 112008383 112008475 93 + 1.653 1.649 -0.015
ENSG00000153208 E022 48.0548066 0.0005326119 2.108737e-01 3.395816e-01 2 112009948 112010066 119 + 1.661 1.718 0.195
ENSG00000153208 E023 40.6917307 0.0008274868 3.482557e-01 4.924758e-01 2 112019413 112019522 110 + 1.594 1.641 0.159
ENSG00000153208 E024 0.3289534 0.0294436314 7.365758e-01   2 112020604 112020654 51 + 0.100 0.148 0.645
ENSG00000153208 E025 44.2594034 0.0020879684 2.158680e-01 3.454454e-01 2 112021422 112021581 160 + 1.619 1.683 0.218
ENSG00000153208 E026 48.6337746 0.0005118693 4.355645e-03 1.413654e-02 2 112022258 112022394 137 + 1.627 1.763 0.461
ENSG00000153208 E027 116.1272572 0.0008553498 2.088456e-15 7.565042e-14 2 112028351 112029293 943 + 1.936 2.192 0.856
ENSG00000153208 E028 3.0035782 0.1756535375 3.192965e-03 1.083476e-02 2 112029294 112029323 30 + 0.182 0.854 3.560
ENSG00000153208 E029 2.8950258 0.1560660096 2.928169e-03 1.005332e-02 2 112029324 112029561 238 + 0.182 0.833 3.477
ENSG00000153208 E030 4.8825543 0.0129812338 6.110868e-02 1.284990e-01 2 112039351 112039436 86 + 0.642 0.898 1.030