ENSG00000153201

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000283195 ENSG00000153201 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP2 protein_coding protein_coding 14.35314 4.307057 22.66659 0.4896195 0.6020943 2.393084 9.9277252 0.1828255 16.7091144 0.06743842 0.8912310 6.438059 0.47750833 0.03963333 0.7398667 0.7002333 1.755332e-12 2.609905e-13 FALSE TRUE
MSTRG.18998.1 ENSG00000153201 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP2 protein_coding   14.35314 4.307057 22.66659 0.4896195 0.6020943 2.393084 1.0921038 0.0000000 3.7347145 0.00000000 0.4317335 8.548712 0.05717083 0.00000000 0.1645333 0.1645333 5.066269e-13 2.609905e-13 FALSE TRUE
MSTRG.18998.7 ENSG00000153201 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP2 protein_coding   14.35314 4.307057 22.66659 0.4896195 0.6020943 2.393084 1.9455160 2.7989048 0.9333763 0.29480781 0.9333763 -1.574102 0.32963333 0.66760000 0.0391000 -0.6285000 1.071683e-02 2.609905e-13 FALSE TRUE
MSTRG.18998.8 ENSG00000153201 HEK293_OSMI2_2hA HEK293_TMG_2hB RANBP2 protein_coding   14.35314 4.307057 22.66659 0.4896195 0.6020943 2.393084 0.5571544 1.2645079 0.0000000 0.43255724 0.0000000 -6.993797 0.09109583 0.27963333 0.0000000 -0.2796333 2.609905e-13 2.609905e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153201 E001 0.4502799 0.0264442076 6.861870e-01 7.887588e-01 2 108719470 108719481 12 + 0.160 0.000 -9.730
ENSG00000153201 E002 0.4502799 0.0264442076 6.861870e-01 7.887588e-01 2 108719482 108719488 7 + 0.160 0.000 -9.713
ENSG00000153201 E003 16.8998003 0.0010110473 1.035241e-09 1.531375e-08 2 108719489 108719552 64 + 1.249 0.234 -4.553
ENSG00000153201 E004 23.3293147 0.0032951134 2.020943e-09 2.825130e-08 2 108719553 108719606 54 + 1.374 0.586 -2.989
ENSG00000153201 E005 25.0900740 0.0121971447 5.748578e-09 7.424165e-08 2 108719607 108719678 72 + 1.406 0.586 -3.097
ENSG00000153201 E006 12.6994637 0.0847662612 1.147478e-04 5.897139e-04 2 108729132 108729134 3 + 1.132 0.234 -4.136
ENSG00000153201 E007 22.6576612 0.0585703698 8.909197e-07 7.478491e-06 2 108729135 108729199 65 + 1.368 0.387 -3.960
ENSG00000153201 E008 21.7227875 0.0083123461 6.185292e-09 7.936234e-08 2 108730774 108730816 43 + 1.346 0.498 -3.304
ENSG00000153201 E009 32.4116310 0.0020918297 2.645724e-11 5.141818e-10 2 108730817 108730885 69 + 1.507 0.778 -2.638
ENSG00000153201 E010 37.9596816 0.0005535055 8.082801e-13 2.015349e-11 2 108731322 108731409 88 + 1.572 0.871 -2.499
ENSG00000153201 E011 32.4403750 0.0006016482 1.791930e-09 2.533590e-08 2 108731410 108731474 65 + 1.501 0.911 -2.104
ENSG00000153201 E012 0.2903454 0.3169808946 1.000000e+00   2 108731475 108731898 424 + 0.112 0.000 -9.123
ENSG00000153201 E013 71.2514583 0.0101944750 4.727184e-14 1.408099e-12 2 108735532 108735762 231 + 1.838 1.165 -2.317
ENSG00000153201 E014 47.0975683 0.0490351028 2.626447e-05 1.584071e-04 2 108736104 108736249 146 + 1.654 1.103 -1.915
ENSG00000153201 E015 48.1464463 0.0005800352 1.251569e-10 2.173888e-09 2 108740489 108740681 193 + 1.659 1.163 -1.718
ENSG00000153201 E016 39.9127689 0.0005470080 1.870489e-11 3.724992e-10 2 108746711 108746798 88 + 1.587 0.981 -2.136
ENSG00000153201 E017 46.1585703 0.0005972735 1.336378e-13 3.730811e-12 2 108748920 108749031 112 + 1.651 1.012 -2.236
ENSG00000153201 E018 52.6113674 0.0004183585 5.748845e-16 2.242795e-14 2 108749032 108749129 98 + 1.707 1.041 -2.321
ENSG00000153201 E019 65.9205039 0.0003593216 3.051332e-17 1.398997e-15 2 108751264 108751445 182 + 1.800 1.204 -2.051
ENSG00000153201 E020 19.1013988 0.0009555163 8.652833e-07 7.285246e-06 2 108751528 108751550 23 + 1.284 0.660 -2.353
ENSG00000153201 E021 55.3379566 0.0961489180 6.147288e-04 2.587220e-03 2 108751551 108751703 153 + 1.722 1.195 -1.816
ENSG00000153201 E022 4.4584101 0.0308172868 2.742119e-01 4.133436e-01 2 108751704 108751870 167 + 0.687 0.498 -0.846
ENSG00000153201 E023 66.7478299 0.0061177557 4.929307e-11 9.169702e-10 2 108751871 108751994 124 + 1.799 1.293 -1.731
ENSG00000153201 E024 50.5073138 0.0024212892 3.221819e-09 4.347321e-08 2 108752998 108753159 162 + 1.676 1.223 -1.562
ENSG00000153201 E025 40.1431943 0.0006880615 4.464731e-09 5.870965e-08 2 108753426 108753563 138 + 1.584 1.094 -1.710
ENSG00000153201 E026 53.0820382 0.0004463892 1.344182e-10 2.323460e-09 2 108753825 108753971 147 + 1.700 1.241 -1.579
ENSG00000153201 E027 71.4595648 0.0049931419 4.261132e-12 9.423987e-11 2 108754905 108755084 180 + 1.829 1.323 -1.730
ENSG00000153201 E028 61.1960751 0.0003694261 7.263430e-18 3.621145e-16 2 108755176 108755259 84 + 1.772 1.119 -2.260
ENSG00000153201 E029 30.2159139 0.0057558862 2.925094e-10 4.769345e-09 2 108758413 108758416 4 + 1.478 0.723 -2.762
ENSG00000153201 E030 50.7225486 0.0004807166 1.900581e-12 4.450123e-11 2 108758417 108758548 132 + 1.687 1.142 -1.889
ENSG00000153201 E031 37.6301514 0.0137147172 3.636344e-05 2.116874e-04 2 108762101 108762195 95 + 1.550 1.142 -1.425
ENSG00000153201 E032 740.7473459 0.0059835707 7.587563e-26 8.972791e-24 2 108763237 108766047 2811 + 2.827 2.448 -1.261
ENSG00000153201 E033 98.4641952 0.0016241316 5.343974e-06 3.778317e-05 2 108766048 108766164 117 + 1.934 1.726 -0.702
ENSG00000153201 E034 725.4987103 0.0102210332 8.438221e-02 1.664198e-01 2 108766165 108768388 2224 + 2.770 2.740 -0.100
ENSG00000153201 E035 171.0115593 0.0019086335 4.690320e-02 1.036520e-01 2 108771701 108771871 171 + 2.111 2.222 0.371
ENSG00000153201 E036 139.1531615 0.0010060592 3.492314e-06 2.577059e-05 2 108772489 108772581 93 + 1.997 2.204 0.691
ENSG00000153201 E037 185.9652458 0.0024349740 1.757758e-06 1.384336e-05 2 108772868 108773046 179 + 2.123 2.335 0.708
ENSG00000153201 E038 202.4817709 0.0028755203 3.312818e-09 4.459310e-08 2 108775732 108775936 205 + 2.148 2.402 0.848
ENSG00000153201 E039 119.4619898 0.0002454485 9.252845e-10 1.380364e-08 2 108777130 108777231 102 + 1.916 2.175 0.868
ENSG00000153201 E040 176.7518845 0.0016694470 5.038583e-15 1.733329e-13 2 108781269 108781429 161 + 2.069 2.376 1.025
ENSG00000153201 E041 80.8161601 0.0074850622 7.142372e-05 3.870869e-04 2 108782128 108782131 4 + 1.745 2.019 0.922
ENSG00000153201 E042 257.0464827 0.0024290612 4.539546e-22 3.644082e-20 2 108782132 108782401 270 + 2.215 2.568 1.177
ENSG00000153201 E043 303.8014988 0.0015559721 3.862645e-40 1.350123e-37 2 108782528 108782862 335 + 2.270 2.672 1.341
ENSG00000153201 E044 548.4567488 0.0120969925 1.970579e-17 9.268129e-16 2 108783596 108785809 2214 + 2.503 2.966 1.540