ENSG00000153066

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000283033 ENSG00000153066 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNDC11 protein_coding protein_coding 22.64664 29.16993 19.36785 2.247184 0.85781 -0.590568 14.254677 14.387615 15.1477362 0.4272133 0.2261197 0.07422449 0.6444667 0.4981000 0.7862333 0.2881333 0.002675642 0.002675642 FALSE TRUE
ENST00000570917 ENSG00000153066 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNDC11 protein_coding processed_transcript 22.64664 29.16993 19.36785 2.247184 0.85781 -0.590568 4.874628 11.849678 0.7144698 2.5044188 0.3651831 -4.03299554 0.1958917 0.3981333 0.0354000 -0.3627333 0.036769751 0.002675642 FALSE TRUE
MSTRG.12066.5 ENSG00000153066 HEK293_OSMI2_2hA HEK293_TMG_2hB TXNDC11 protein_coding   22.64664 29.16993 19.36785 2.247184 0.85781 -0.590568 1.116825 1.162257 0.9313280 0.1309893 0.3394621 -0.31651964 0.0505875 0.0410000 0.0485000 0.0075000 0.959022173 0.002675642 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153066 E001 272.8641260 0.0019661890 2.698234e-14 8.322571e-13 16 11679083 11679507 425 - 2.270 2.496 0.754
ENSG00000153066 E002 82.5100278 0.0006432033 4.596687e-13 1.191936e-11 16 11679508 11679516 9 - 1.689 2.001 1.049
ENSG00000153066 E003 257.8449317 0.0002426856 3.640685e-22 2.946249e-20 16 11679517 11679695 179 - 2.246 2.471 0.750
ENSG00000153066 E004 271.8458165 0.0018190364 3.154968e-05 1.867402e-04 16 11679696 11679837 142 - 2.347 2.463 0.387
ENSG00000153066 E005 170.0317826 0.0027430791 4.479569e-04 1.959186e-03 16 11684165 11684234 70 - 2.137 2.263 0.420
ENSG00000153066 E006 101.0959790 0.0003428388 1.238882e-04 6.316339e-04 16 11684235 11684245 11 - 1.906 2.043 0.458
ENSG00000153066 E007 227.4106424 0.0057369525 3.078492e-01 4.500849e-01 16 11687857 11687966 110 - 2.322 2.357 0.116
ENSG00000153066 E008 234.1413317 0.0019050848 3.598523e-01 5.041631e-01 16 11688303 11688445 143 - 2.344 2.365 0.068
ENSG00000153066 E009 0.4783925 0.0211597660 3.956851e-01 5.394844e-01 16 11688446 11688568 123 - 0.249 0.105 -1.494
ENSG00000153066 E010 1.1146300 0.0240639711 1.236024e-01 2.250918e-01 16 11689988 11690097 110 - 0.467 0.190 -1.817
ENSG00000153066 E011 2.4441591 0.1369899179 9.735845e-01 9.875126e-01 16 11690734 11691289 556 - 0.521 0.536 0.071
ENSG00000153066 E012 483.5407015 0.0005916298 4.996851e-01 6.359687e-01 16 11691290 11691989 700 - 2.685 2.666 -0.063
ENSG00000153066 E013 78.1937303 0.0060747761 2.606831e-01 3.982493e-01 16 11691990 11692013 24 - 1.928 1.866 -0.209
ENSG00000153066 E014 90.2562088 0.0027210834 2.657188e-02 6.509967e-02 16 11692014 11692049 36 - 2.013 1.910 -0.343
ENSG00000153066 E015 93.5581053 0.0003355826 1.478249e-04 7.376917e-04 16 11692050 11692082 33 - 2.047 1.903 -0.485
ENSG00000153066 E016 0.3289534 0.0295826103 8.127640e-01   16 11692083 11692242 160 - 0.142 0.105 -0.496
ENSG00000153066 E017 82.0922299 0.0003767491 1.587024e-02 4.244587e-02 16 11698125 11698133 9 - 1.965 1.864 -0.338
ENSG00000153066 E018 206.1767045 0.0004396942 1.283578e-06 1.041547e-05 16 11698134 11698325 192 - 2.382 2.252 -0.433
ENSG00000153066 E019 131.9995091 0.0016160384 6.632173e-07 5.724385e-06 16 11700452 11700564 113 - 2.218 2.035 -0.612
ENSG00000153066 E020 1.6210214 0.0086590308 2.559601e-01 3.929186e-01 16 11703670 11703750 81 - 0.521 0.322 -1.079
ENSG00000153066 E021 0.3268771 0.0306598046 8.135222e-01   16 11721314 11721435 122 - 0.142 0.105 -0.495
ENSG00000153066 E022 128.3023523 0.0057532882 3.780727e-02 8.697812e-02 16 11721577 11721670 94 - 2.163 2.053 -0.368
ENSG00000153066 E023 116.7382027 0.0005056237 1.980558e-06 1.542110e-05 16 11730645 11730774 130 - 2.152 1.987 -0.555
ENSG00000153066 E024 111.2133927 0.0027517944 1.714134e-06 1.353130e-05 16 11733982 11734079 98 - 2.152 1.946 -0.692
ENSG00000153066 E025 134.8751858 0.0068895726 8.584455e-09 1.071343e-07 16 11736017 11736233 217 - 2.280 1.984 -0.990
ENSG00000153066 E026 72.9433319 0.0292056939 2.293750e-05 1.402298e-04 16 11742477 11742857 381 - 2.062 1.658 -1.358