ENSG00000153048

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000311052 ENSG00000153048 HEK293_OSMI2_2hA HEK293_TMG_2hB CARHSP1 protein_coding protein_coding 121.5577 227.7261 80.42312 4.427606 0.927519 -1.501501 28.06901 47.09446 21.59076 1.516220 0.6466884 -1.124782 0.2410083 0.2068667 0.2683667 0.06150000 0.0007642854 7.510784e-05 FALSE  
ENST00000561530 ENSG00000153048 HEK293_OSMI2_2hA HEK293_TMG_2hB CARHSP1 protein_coding protein_coding 121.5577 227.7261 80.42312 4.427606 0.927519 -1.501501 20.75649 33.41905 12.67621 5.714203 0.8491845 -1.397841 0.1796000 0.1477333 0.1578667 0.01013333 0.8951492769 7.510784e-05 FALSE  
MSTRG.12012.1 ENSG00000153048 HEK293_OSMI2_2hA HEK293_TMG_2hB CARHSP1 protein_coding   121.5577 227.7261 80.42312 4.427606 0.927519 -1.501501 70.23118 142.93164 44.45105 9.158851 1.4027723 -1.684812 0.5577583 0.6265667 0.5525000 -0.07406667 0.2526019003 7.510784e-05 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153048 E001 0.2998086 2.949098e-02 3.917756e-01   16 8824107 8824173 67 - 0.201 0.072 -1.715
ENSG00000153048 E002 6.3262330 1.205837e-02 3.779876e-01 5.222906e-01 16 8852942 8852942 1 - 0.874 0.742 -0.521
ENSG00000153048 E003 13.0595530 1.762465e-03 5.509827e-01 6.805230e-01 16 8852943 8852946 4 - 1.107 1.037 -0.251
ENSG00000153048 E004 1989.4657116 3.956138e-04 1.192034e-17 5.788960e-16 16 8852947 8854920 1974 - 3.285 3.180 -0.350
ENSG00000153048 E005 259.2520318 2.365392e-03 2.835325e-01 4.236717e-01 16 8854921 8855040 120 - 2.295 2.329 0.112
ENSG00000153048 E006 392.9560840 2.694501e-03 9.144620e-01 9.498554e-01 16 8855041 8855064 24 - 2.507 2.499 -0.029
ENSG00000153048 E007 1139.3442525 6.302039e-04 5.215411e-01 6.554189e-01 16 8855065 8855213 149 - 2.957 2.963 0.019
ENSG00000153048 E008 736.3522465 1.236825e-03 2.603137e-01 3.977999e-01 16 8855214 8855230 17 - 2.756 2.777 0.069
ENSG00000153048 E009 637.9682431 3.660602e-04 7.512277e-01 8.377107e-01 16 8855231 8855233 3 - 2.710 2.711 0.002
ENSG00000153048 E010 913.1007640 2.910439e-04 5.999683e-01 7.212800e-01 16 8855234 8855270 37 - 2.877 2.863 -0.045
ENSG00000153048 E011 769.6075975 9.179068e-05 2.075570e-01 3.355497e-01 16 8855271 8855289 19 - 2.779 2.793 0.046
ENSG00000153048 E012 842.0201925 9.037149e-05 5.528097e-03 1.736008e-02 16 8855290 8855326 37 - 2.801 2.837 0.120
ENSG00000153048 E013 8.2991524 2.526786e-03 3.364572e-04 1.526251e-03 16 8857464 8858089 626 - 1.180 0.767 -1.543
ENSG00000153048 E014 4.8776109 1.267905e-02 1.318098e-03 5.037719e-03 16 8858090 8858349 260 - 1.018 0.566 -1.811
ENSG00000153048 E015 1096.4478648 1.204622e-04 1.228454e-07 1.226492e-06 16 8858350 8858417 68 - 2.890 2.956 0.221
ENSG00000153048 E016 930.7688683 1.171864e-04 3.231564e-03 1.094886e-02 16 8858418 8858472 55 - 2.843 2.880 0.123
ENSG00000153048 E017 8.6630683 2.868291e-02 1.003000e-03 3.968742e-03 16 8858473 8858912 440 - 1.213 0.777 -1.621
ENSG00000153048 E018 5.3226133 4.798167e-03 3.320270e-01 4.756475e-01 16 8858913 8859063 151 - 0.838 0.695 -0.576
ENSG00000153048 E019 7.1607132 6.892070e-03 6.581497e-02 1.363971e-01 16 8859064 8859170 107 - 1.018 0.780 -0.909
ENSG00000153048 E020 1139.8122303 8.149185e-04 1.302519e-01 2.345121e-01 16 8859171 8859330 160 - 2.943 2.965 0.070
ENSG00000153048 E021 497.9041177 2.077018e-03 9.683356e-01 9.842279e-01 16 8859331 8859335 5 - 2.606 2.599 -0.022
ENSG00000153048 E022 26.2392119 7.570876e-04 8.303444e-01 8.935448e-01 16 8859336 8859351 16 - 1.335 1.347 0.041
ENSG00000153048 E023 2.7439662 4.095908e-02 5.227229e-01 6.564773e-01 16 8860105 8860218 114 - 0.596 0.474 -0.575
ENSG00000153048 E024 2.5755981 5.192622e-02 4.124260e-01 5.559736e-01 16 8860219 8860309 91 - 0.338 0.502 0.888
ENSG00000153048 E025 1.8370794 7.954846e-03 7.814551e-01 8.595834e-01 16 8861642 8861665 24 - 0.442 0.387 -0.298
ENSG00000153048 E026 3.0557919 3.887863e-02 8.439761e-01 9.028518e-01 16 8861666 8861810 145 - 0.526 0.564 0.176
ENSG00000153048 E027 0.8576959 3.282076e-01 2.268788e-01 3.586635e-01 16 8867252 8867428 177 - 0.444 0.136 -2.272
ENSG00000153048 E028 3.0173703 5.112399e-03 5.514375e-01 6.809027e-01 16 8867707 8868048 342 - 0.442 0.546 0.511
ENSG00000153048 E029 10.3974353 3.772782e-03 7.273803e-01 8.201162e-01 16 8868049 8868160 112 - 0.937 0.975 0.142
ENSG00000153048 E030 9.8429592 9.154959e-03 8.261454e-01 8.905915e-01 16 8868161 8868326 166 - 0.966 0.933 -0.122
ENSG00000153048 E031 3.4008278 5.631863e-03 5.181143e-01 6.523885e-01 16 8868327 8868401 75 - 0.657 0.546 -0.490
ENSG00000153048 E032 18.8840309 3.344252e-02 2.882051e-01 4.287600e-01 16 8868532 8868965 434 - 1.086 1.226 0.499
ENSG00000153048 E033 468.9551887 3.453596e-03 9.631424e-01 9.807207e-01 16 8868966 8869032 67 - 2.577 2.574 -0.011