ENSG00000153046

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000343762 ENSG00000153046 HEK293_OSMI2_2hA HEK293_TMG_2hB CDYL protein_coding protein_coding 11.78023 8.389216 17.2199 0.337915 0.3730582 1.036588 7.2354565 6.4299749 7.840845 0.4447716 0.4345009 0.2857929 0.64501250 0.76486667 0.45676667 -0.30810000 1.548692e-06 1.33208e-13 FALSE TRUE
ENST00000397588 ENSG00000153046 HEK293_OSMI2_2hA HEK293_TMG_2hB CDYL protein_coding protein_coding 11.78023 8.389216 17.2199 0.337915 0.3730582 1.036588 1.4891032 0.6352022 3.530069 0.6352022 0.3745284 2.4559541 0.11185000 0.07963333 0.20500000 0.12536667 1.735021e-01 1.33208e-13 FALSE TRUE
ENST00000483019 ENSG00000153046 HEK293_OSMI2_2hA HEK293_TMG_2hB CDYL protein_coding processed_transcript 11.78023 8.389216 17.2199 0.337915 0.3730582 1.036588 0.9079024 0.0000000 3.518686 0.0000000 0.6960611 8.4629871 0.05266667 0.00000000 0.20283333 0.20283333 1.332080e-13 1.33208e-13   FALSE
MSTRG.27563.9 ENSG00000153046 HEK293_OSMI2_2hA HEK293_TMG_2hB CDYL protein_coding   11.78023 8.389216 17.2199 0.337915 0.3730582 1.036588 1.4842580 0.8836462 1.192259 0.4492526 0.1281867 0.4279715 0.12960000 0.10370000 0.06903333 -0.03466667 1.000000e+00 1.33208e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153046 E001 0.0000000       6 4706159 4706251 93 +      
ENSG00000153046 E002 0.0000000       6 4715741 4715840 100 +      
ENSG00000153046 E003 0.0000000       6 4715841 4715881 41 +      
ENSG00000153046 E004 0.0000000       6 4733159 4733248 90 +      
ENSG00000153046 E005 0.0000000       6 4734762 4734844 83 +      
ENSG00000153046 E006 0.0000000       6 4772971 4773040 70 +      
ENSG00000153046 E007 0.0000000       6 4773041 4773178 138 +      
ENSG00000153046 E008 1.7026957 0.0081939624 2.348462e-02 5.874550e-02 6 4776404 4776441 38 + 0.558 0.148 -2.687
ENSG00000153046 E009 1.7026957 0.0081939624 2.348462e-02 5.874550e-02 6 4776442 4776443 2 + 0.558 0.148 -2.687
ENSG00000153046 E010 3.0175553 0.0060543870 3.570879e-04 1.607634e-03 6 4776444 4776496 53 + 0.775 0.148 -3.613
ENSG00000153046 E011 24.0157866 0.0007988769 5.105110e-03 1.621643e-02 6 4776497 4776807 311 + 1.469 1.275 -0.674
ENSG00000153046 E012 0.1515154 0.0435110810 7.244030e-01   6 4836098 4836308 211 + 0.101 0.000 -9.607
ENSG00000153046 E013 0.1482932 0.0408437953 3.267814e-01   6 4889992 4890126 135 + 0.000 0.148 9.592
ENSG00000153046 E014 177.0721771 0.0011123984 1.200571e-09 1.752000e-08 6 4891713 4892103 391 + 2.315 2.142 -0.575
ENSG00000153046 E015 156.0140938 0.0005751196 1.265800e-04 6.437810e-04 6 4892104 4892379 276 + 2.238 2.137 -0.340
ENSG00000153046 E016 0.0000000       6 4928695 4928728 34 +      
ENSG00000153046 E017 67.6534730 0.0004173511 1.024638e-01 1.942662e-01 6 4935515 4935580 66 + 1.862 1.802 -0.203
ENSG00000153046 E018 117.5708709 0.0002631903 6.212874e-01 7.382522e-01 6 4935581 4935771 191 + 2.077 2.071 -0.020
ENSG00000153046 E019 110.0037427 0.0003227190 6.583207e-01 7.675122e-01 6 4937565 4937737 173 + 2.032 2.056 0.081
ENSG00000153046 E020 135.7368159 0.0006652276 4.331299e-01 5.755752e-01 6 4943546 4943756 211 + 2.119 2.153 0.114
ENSG00000153046 E021 1.2575109 0.0106452312 5.665719e-01 6.935320e-01 6 4943757 4943813 57 + 0.311 0.418 0.633
ENSG00000153046 E022 105.0057261 0.0003250118 7.037234e-02 1.439718e-01 6 4952266 4952373 108 + 1.991 2.062 0.238
ENSG00000153046 E023 58.3710492 0.0004352881 1.023477e-01 1.941022e-01 6 4952374 4952409 36 + 1.735 1.819 0.283
ENSG00000153046 E024 462.3667308 0.0012667731 2.279038e-08 2.629298e-07 6 4953898 4955551 1654 + 2.613 2.722 0.363