ENSG00000153015

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381070 ENSG00000153015 HEK293_OSMI2_2hA HEK293_TMG_2hB CWC27 protein_coding protein_coding 17.46978 7.333186 25.15343 0.7485395 0.8685769 1.77685 3.670397 2.012436 5.209921 0.1938341 0.1335334 1.3679338 0.2352250 0.2765000 0.2074667 -0.06903333 0.15122242 0.01779525 FALSE TRUE
ENST00000687314 ENSG00000153015 HEK293_OSMI2_2hA HEK293_TMG_2hB CWC27 protein_coding protein_coding 17.46978 7.333186 25.15343 0.7485395 0.8685769 1.77685 4.931016 3.563106 6.238017 0.2777297 0.1510742 0.8062197 0.3467083 0.5004333 0.2483000 -0.25213333 0.01779525 0.01779525 FALSE TRUE
ENST00000688896 ENSG00000153015 HEK293_OSMI2_2hA HEK293_TMG_2hB CWC27 protein_coding protein_coding 17.46978 7.333186 25.15343 0.7485395 0.8685769 1.77685 7.821731 1.102809 12.273648 0.7515378 0.6930652 3.4644618 0.3492042 0.1334000 0.4876667 0.35426667 0.21046052 0.01779525 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000153015 E001 0.0000000       5 64766368 64766520 153 +      
ENSG00000153015 E002 0.0000000       5 64767997 64768089 93 +      
ENSG00000153015 E003 1.5511803 0.0091320969 1.605907e-01 0.2759093296 5 64768918 64768923 6 + 0.455 0.181 -1.844
ENSG00000153015 E004 1.5511803 0.0091320969 1.605907e-01 0.2759093296 5 64768924 64768929 6 + 0.455 0.181 -1.844
ENSG00000153015 E005 1.8415257 0.0116362939 9.048660e-02 0.1758972218 5 64768930 64768933 4 + 0.513 0.181 -2.133
ENSG00000153015 E006 5.8961669 0.0106550455 3.343273e-04 0.0015176427 5 64768934 64768939 6 + 0.935 0.308 -2.882
ENSG00000153015 E007 12.0380014 0.0822097542 1.489939e-02 0.0402596451 5 64768940 64768943 4 + 1.181 0.760 -1.574
ENSG00000153015 E008 12.9989390 0.0262247282 6.305602e-03 0.0194167600 5 64768944 64768945 2 + 1.204 0.828 -1.390
ENSG00000153015 E009 22.2430429 0.0422924708 4.821360e-02 0.1060136213 5 64768946 64768959 14 + 1.399 1.153 -0.865
ENSG00000153015 E010 43.0308794 0.0010755920 1.688887e-04 0.0008303607 5 64768960 64768986 27 + 1.678 1.436 -0.828
ENSG00000153015 E011 81.2837515 0.0035265327 4.775219e-04 0.0020738884 5 64768987 64769075 89 + 1.937 1.750 -0.629
ENSG00000153015 E012 113.2854114 0.0023062428 1.326943e-02 0.0365454843 5 64769076 64769188 113 + 2.061 1.951 -0.370
ENSG00000153015 E013 0.0000000       5 64773818 64773895 78 +      
ENSG00000153015 E014 91.2393100 0.0003642605 3.296842e-01 0.4732144429 5 64774691 64774787 97 + 1.948 1.905 -0.146
ENSG00000153015 E015 62.7681434 0.0004012033 7.342288e-01 0.8252396369 5 64781921 64781948 28 + 1.781 1.761 -0.068
ENSG00000153015 E016 98.6013842 0.0003260431 2.054975e-01 0.3330329712 5 64781949 64782033 85 + 1.985 1.932 -0.178
ENSG00000153015 E017 140.8534544 0.0007005335 1.052951e-02 0.0300443827 5 64783836 64783979 144 + 2.148 2.057 -0.306
ENSG00000153015 E018 1.2210915 0.0112304210 1.158799e-01 0.2140637730 5 64783980 64785480 1501 + 0.209 0.486 1.741
ENSG00000153015 E019 132.1683884 0.0002642065 5.309423e-02 0.1146494783 5 64785481 64785579 99 + 2.115 2.046 -0.230
ENSG00000153015 E020 0.5910844 0.3968801291 4.977116e-01 0.6342488225 5 64785580 64786179 600 + 0.149 0.299 1.273
ENSG00000153015 E021 126.0183717 0.0004320953 2.253237e-01 0.3567988137 5 64786524 64786627 104 + 2.088 2.042 -0.154
ENSG00000153015 E022 2.2027313 0.0476633443 5.941956e-01 0.7164610364 5 64786628 64787738 1111 + 0.513 0.407 -0.542
ENSG00000153015 E023 113.7194008 0.0003450489 6.567941e-01 0.7662793289 5 64788951 64789020 70 + 2.028 2.040 0.040
ENSG00000153015 E024 133.5055611 0.0003204387 2.089711e-01 0.3372882782 5 64800248 64800327 80 + 2.088 2.125 0.124
ENSG00000153015 E025 96.6307548 0.0003143051 3.311750e-01 0.4747551884 5 64801302 64801332 31 + 1.950 1.984 0.111
ENSG00000153015 E026 1.8572179 0.0287783688 3.618187e-01 0.5062404108 5 64801333 64804228 2896 + 0.485 0.308 -0.997
ENSG00000153015 E027 149.5756458 0.0003086318 2.490933e-01 0.3848504608 5 64804229 64804334 106 + 2.138 2.170 0.105
ENSG00000153015 E028 103.4986358 0.0003618033 4.286600e-03 0.0139449610 5 64804335 64804386 52 + 1.954 2.054 0.335
ENSG00000153015 E029 0.2934659 0.0293686914 4.983036e-01   5 64804387 64804907 521 + 0.081 0.180 1.323
ENSG00000153015 E030 6.1007213 0.1205362259 9.716538e-01 0.9862800862 5 64807599 64810298 2700 + 0.841 0.816 -0.097
ENSG00000153015 E031 4.4657985 0.0592738732 3.517347e-02 0.0819730708 5 64815285 64819083 3799 + 0.817 0.403 -1.863
ENSG00000153015 E032 8.4345243 0.0025849869 5.463211e-03 0.0171907950 5 64821638 64822667 1030 + 0.816 1.126 1.156
ENSG00000153015 E033 0.0000000       5 64842783 64842965 183 +      
ENSG00000153015 E034 11.2841772 0.0031925451 3.639553e-03 0.0121256777 5 64844923 64854696 9774 + 1.145 0.789 -1.329
ENSG00000153015 E035 1.1050531 0.0118027605 3.844311e-01 0.5285760554 5 64863520 64867850 4331 + 0.349 0.181 -1.259
ENSG00000153015 E036 0.5483223 0.0212222506 1.717059e-01 0.2904390291 5 64867851 64868482 632 + 0.081 0.308 2.328
ENSG00000153015 E037 0.2903454 0.3310450549 7.079509e-01   5 64881389 64884155 2767 + 0.149 0.000 -9.555
ENSG00000153015 E038 0.0000000       5 64884156 64884285 130 +      
ENSG00000153015 E039 0.2903454 0.3310450549 7.079509e-01   5 64884286 64885442 1157 + 0.149 0.000 -9.555
ENSG00000153015 E040 116.6118713 0.0008767972 2.086042e-04 0.0010007961 5 64885443 64885546 104 + 1.997 2.125 0.430
ENSG00000153015 E041 12.0346269 0.0047754519 1.291229e-01 0.2329508780 5 64893951 64900499 6549 + 1.138 0.966 -0.629
ENSG00000153015 E042 0.6633060 0.0216127543 9.019990e-01 0.9415605421 5 64901866 64902742 877 + 0.209 0.181 -0.258
ENSG00000153015 E043 0.0000000       5 64970454 64970515 62 +      
ENSG00000153015 E044 108.3616638 0.0008013179 5.347239e-05 0.0002990990 5 64971703 64971812 110 + 1.960 2.104 0.483
ENSG00000153015 E045 126.7988789 0.0003119916 4.166056e-03 0.0136086431 5 64977135 64977238 104 + 2.046 2.137 0.303
ENSG00000153015 E046 0.3666179 0.0289378121 4.963573e-01 0.6330498952 5 64977239 64977823 585 + 0.081 0.181 1.328
ENSG00000153015 E047 0.0000000       5 64998103 64998144 42 +      
ENSG00000153015 E048 1.6813993 0.1105923563 7.096508e-02 0.1449469757 5 65007649 65008153 505 + 0.260 0.614 1.920
ENSG00000153015 E049 213.9243712 0.0004660826 1.683022e-03 0.0062288728 5 65018159 65020990 2832 + 2.278 2.356 0.260
ENSG00000153015 E050 0.1472490 0.0439685732 1.000000e+00   5 65099252 65102412 3161 + 0.081 0.000 -8.875