ENSG00000152942

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305138 ENSG00000152942 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD17 protein_coding protein_coding 11.71695 5.305402 18.12245 0.6071427 0.8584795 1.770323 1.5939045 0.21847131 3.0249501 0.14362053 0.25390662 3.731588 0.11752083 0.03963333 0.16663333 0.12700000 6.788818e-02 7.567783e-18 FALSE TRUE
ENST00000354312 ENSG00000152942 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD17 protein_coding protein_coding 11.71695 5.305402 18.12245 0.6071427 0.8584795 1.770323 3.0497201 0.14486057 3.7045435 0.14486057 2.09925055 4.584143 0.21010833 0.03390000 0.20103333 0.16713333 5.447478e-01 7.567783e-18 FALSE TRUE
ENST00000358030 ENSG00000152942 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD17 protein_coding protein_coding 11.71695 5.305402 18.12245 0.6071427 0.8584795 1.770323 0.2337827 1.24728728 0.0000000 0.37152481 0.00000000 -6.974171 0.05379583 0.25556667 0.00000000 -0.25556667 3.135164e-08 7.567783e-18 FALSE TRUE
ENST00000504177 ENSG00000152942 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD17 protein_coding processed_transcript 11.71695 5.305402 18.12245 0.6071427 0.8584795 1.770323 0.2213762 0.93390838 0.0000000 0.93390838 0.00000000 -6.560575 0.04109583 0.14653333 0.00000000 -0.14653333 6.148854e-01 7.567783e-18 FALSE TRUE
ENST00000509734 ENSG00000152942 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD17 protein_coding protein_coding 11.71695 5.305402 18.12245 0.6071427 0.8584795 1.770323 1.6513880 0.36978956 2.1528998 0.19580931 0.36692648 2.509695 0.11493333 0.06940000 0.12126667 0.05186667 6.543982e-01 7.567783e-18 FALSE TRUE
ENST00000513214 ENSG00000152942 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD17 protein_coding protein_coding 11.71695 5.305402 18.12245 0.6071427 0.8584795 1.770323 0.5569442 1.07117536 0.2350851 0.22291842 0.04276717 -2.141246 0.10448333 0.19766667 0.01286667 -0.18480000 7.567783e-18 7.567783e-18 FALSE TRUE
ENST00000521422 ENSG00000152942 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD17 protein_coding protein_coding 11.71695 5.305402 18.12245 0.6071427 0.8584795 1.770323 1.7425407 0.09577041 4.1098149 0.09577041 1.26919993 5.283572 0.11154167 0.01816667 0.22916667 0.21100000 3.040338e-02 7.567783e-18 FALSE TRUE
ENST00000616683 ENSG00000152942 HEK293_OSMI2_2hA HEK293_TMG_2hB RAD17 protein_coding protein_coding 11.71695 5.305402 18.12245 0.6071427 0.8584795 1.770323 1.0362481 0.68462832 2.2112037 0.36809008 0.59603319 1.677029 0.08229583 0.14160000 0.12450000 -0.01710000 9.547043e-01 7.567783e-18 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152942 E001 0.0000000       5 69369293 69369296 4 +      
ENSG00000152942 E002 0.0000000       5 69369297 69369309 13 +      
ENSG00000152942 E003 0.6017953 0.1638216252 5.228473e-01 0.6565900106 5 69369310 69369464 155 + 0.200 0.000 -10.056
ENSG00000152942 E004 6.9634683 0.0166447754 7.262804e-02 0.1477208571 5 69369806 69369817 12 + 0.862 0.590 -1.119
ENSG00000152942 E005 7.1107173 0.0232890431 7.080513e-02 0.1446873575 5 69369818 69369819 2 + 0.871 0.590 -1.154
ENSG00000152942 E006 7.2558900 0.0237846263 6.372883e-02 0.1329070363 5 69369820 69369820 1 + 0.879 0.590 -1.186
ENSG00000152942 E007 9.7897673 0.0265784541 2.748442e-02 0.0669767692 5 69369821 69369824 4 + 0.996 0.664 -1.302
ENSG00000152942 E008 15.5153445 0.0011359908 1.817777e-04 0.0008855948 5 69369825 69369841 17 + 1.185 0.728 -1.720
ENSG00000152942 E009 23.3625876 0.0009640770 1.662065e-05 0.0001049822 5 69369842 69369908 67 + 1.349 0.916 -1.558
ENSG00000152942 E010 22.8046989 0.0017989012 3.444271e-05 0.0002017584 5 69369909 69369933 25 + 1.338 0.916 -1.518
ENSG00000152942 E011 12.8006245 0.0020717212 9.100991e-01 0.9468542892 5 69369934 69370059 126 + 1.045 1.074 0.108
ENSG00000152942 E012 9.4488398 0.0288725172 4.677014e-02 0.1034146326 5 69370060 69370091 32 + 0.854 1.166 1.150
ENSG00000152942 E013 16.3907627 0.0028545628 2.780189e-01 0.4176500287 5 69370092 69370190 99 + 1.113 1.264 0.537
ENSG00000152942 E014 17.0893679 0.0010574530 8.359537e-01 0.8974421240 5 69370191 69370241 51 + 1.146 1.210 0.227
ENSG00000152942 E015 14.3903619 0.0012116687 7.813038e-01 0.8595167181 5 69370242 69370245 4 + 1.088 1.100 0.044
ENSG00000152942 E016 17.9397801 0.0010084702 5.867277e-01 0.7102336960 5 69370246 69370284 39 + 1.181 1.169 -0.042
ENSG00000152942 E017 15.2067756 0.0011524660 3.479152e-03 0.0116645114 5 69370705 69371034 330 + 1.160 0.832 -1.213
ENSG00000152942 E018 30.2470926 0.0007014625 1.972196e-02 0.0509007345 5 69371035 69371083 49 + 1.420 1.265 -0.539
ENSG00000152942 E019 33.6255570 0.0041184284 8.278256e-03 0.0244869421 5 69371084 69371171 88 + 1.470 1.282 -0.651
ENSG00000152942 E020 4.9972706 0.0032752933 1.394587e-01 0.2472886585 5 69371454 69371557 104 + 0.731 0.502 -1.012
ENSG00000152942 E021 18.8714782 0.0126443692 1.031595e-01 0.1952861038 5 69372034 69372054 21 + 1.225 1.076 -0.535
ENSG00000152942 E022 26.8869158 0.0055142422 1.864889e-01 0.3093455949 5 69372055 69372156 102 + 1.360 1.282 -0.274
ENSG00000152942 E023 32.4642224 0.0130551965 1.986370e-01 0.3244822335 5 69372157 69372217 61 + 1.439 1.359 -0.279
ENSG00000152942 E024 85.5186372 0.0027564889 1.070222e-02 0.0304594218 5 69373830 69374087 258 + 1.851 1.756 -0.321
ENSG00000152942 E025 46.6580745 0.0166441258 2.593302e-01 0.3967050956 5 69374628 69374711 84 + 1.586 1.532 -0.185
ENSG00000152942 E026 73.9571614 0.0035961073 1.213417e-03 0.0046865127 5 69381901 69382057 157 + 1.798 1.643 -0.526
ENSG00000152942 E027 0.2966881 0.0269885833 1.000000e+00   5 69384080 69384197 118 + 0.111 0.000 -9.020
ENSG00000152942 E028 70.6496149 0.0003929892 1.054137e-01 0.1987293046 5 69384797 69384933 137 + 1.761 1.720 -0.140
ENSG00000152942 E029 41.0292025 0.0006348312 3.439880e-01 0.4880436287 5 69386043 69386095 53 + 1.528 1.507 -0.071
ENSG00000152942 E030 47.9323906 0.0004986708 1.280024e-01 0.2313767007 5 69386180 69386222 43 + 1.599 1.545 -0.185
ENSG00000152942 E031 68.7657534 0.0004172614 1.372490e-01 0.2442456992 5 69386223 69386305 83 + 1.749 1.714 -0.119
ENSG00000152942 E032 62.5111099 0.0005534428 3.971987e-01 0.5409787704 5 69386396 69386465 70 + 1.704 1.701 -0.007
ENSG00000152942 E033 78.1750594 0.0012342866 3.474854e-01 0.4917095572 5 69389034 69389145 112 + 1.800 1.797 -0.011
ENSG00000152942 E034 96.5403544 0.0048201866 3.085908e-01 0.4508741015 5 69391831 69391967 137 + 1.890 1.880 -0.034
ENSG00000152942 E035 54.7995976 0.0030478057 6.543407e-01 0.7645234427 5 69391968 69392013 46 + 1.646 1.662 0.055
ENSG00000152942 E036 0.0000000       5 69392771 69392892 122 +      
ENSG00000152942 E037 65.3264852 0.0003828231 9.127268e-01 0.9486920853 5 69393155 69393240 86 + 1.715 1.754 0.134
ENSG00000152942 E038 92.7428213 0.0016562458 5.887635e-01 0.7119295585 5 69393354 69393500 147 + 1.856 1.927 0.239
ENSG00000152942 E039 80.8341188 0.0008682740 7.059257e-02 0.1443246044 5 69396397 69396546 150 + 1.784 1.915 0.442
ENSG00000152942 E040 75.1431479 0.0012034771 1.991516e-04 0.0009602127 5 69400049 69400169 121 + 1.727 1.952 0.758
ENSG00000152942 E041 43.5045889 0.0050654255 8.825428e-03 0.0258459851 5 69410493 69410513 21 + 1.497 1.720 0.761
ENSG00000152942 E042 55.7239418 0.0099518483 2.252414e-02 0.0567709391 5 69410514 69410550 37 + 1.608 1.815 0.700
ENSG00000152942 E043 233.5942970 0.0369675688 4.064030e-03 0.0133215390 5 69414031 69414801 771 + 2.193 2.495 1.007