ENSG00000152894

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368202 ENSG00000152894 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRK protein_coding processed_transcript 8.482985 5.32665 11.42441 0.3281694 0.2535901 1.099376 0.2081507 0.62221534 0.04305614 0.28698154 0.04305614 -3.5748244 0.04034167 0.111466667 0.00360000 -0.1078667 2.756502e-03 3.60362e-12   FALSE
ENST00000368215 ENSG00000152894 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRK protein_coding protein_coding 8.482985 5.32665 11.42441 0.3281694 0.2535901 1.099376 0.9787347 0.02080989 1.70506113 0.01238316 0.13661906 5.7987225 0.08000417 0.004133333 0.14956667 0.1454333 3.603620e-12 3.60362e-12 FALSE TRUE
ENST00000368226 ENSG00000152894 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRK protein_coding protein_coding 8.482985 5.32665 11.42441 0.3281694 0.2535901 1.099376 5.6396081 3.75853717 6.56672289 0.17374193 0.15008333 0.8033643 0.69678750 0.707233333 0.57550000 -0.1317333 2.141540e-02 3.60362e-12 FALSE TRUE
ENST00000525459 ENSG00000152894 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRK protein_coding protein_coding 8.482985 5.32665 11.42441 0.3281694 0.2535901 1.099376 0.2619090 0.50184327 0.42773051 0.11903476 0.14008071 -0.2256592 0.03553333 0.096866667 0.03696667 -0.0599000 1.981893e-01 3.60362e-12 FALSE TRUE
MSTRG.28942.6 ENSG00000152894 HEK293_OSMI2_2hA HEK293_TMG_2hB PTPRK protein_coding   8.482985 5.32665 11.42441 0.3281694 0.2535901 1.099376 0.8122036 0.04035473 1.41464803 0.03146765 0.24085069 4.8223343 0.06819167 0.007933333 0.12353333 0.1156000 8.111247e-06 3.60362e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152894 E001 45.7815253 0.0414127987 5.056620e-04 2.181449e-03 6 127968785 127968976 192 - 1.458 1.879 1.430
ENSG00000152894 E002 159.3346649 0.0025343283 9.986311e-25 1.062852e-22 6 127968977 127969836 860 - 2.016 2.394 1.263
ENSG00000152894 E003 27.6090822 0.0007849068 2.555423e-03 8.928428e-03 6 127969837 127969895 59 - 1.343 1.559 0.744
ENSG00000152894 E004 47.3622018 0.0022385354 1.268549e-03 4.872528e-03 6 127969896 127970069 174 - 1.580 1.773 0.654
ENSG00000152894 E005 23.0359802 0.0008208703 5.056098e-01 6.413671e-01 6 127970070 127970112 43 - 1.334 1.397 0.218
ENSG00000152894 E006 63.6249349 0.0003829264 2.451720e-02 6.088528e-02 6 127970113 127970280 168 - 1.747 1.862 0.390
ENSG00000152894 E007 61.6655749 0.0004407145 1.209123e-01 2.212523e-01 6 127973022 127973157 136 - 1.743 1.829 0.289
ENSG00000152894 E008 64.0396483 0.0003846974 3.153450e-02 7.494815e-02 6 127973664 127973827 164 - 1.749 1.860 0.375
ENSG00000152894 E009 64.8916393 0.0003971542 4.590245e-03 1.479227e-02 6 127976657 127976782 126 - 1.742 1.882 0.474
ENSG00000152894 E010 70.3182230 0.0004414084 4.480678e-04 1.959625e-03 6 127976923 127977054 132 - 1.765 1.930 0.556
ENSG00000152894 E011 72.9661859 0.0004766434 1.471290e-01 2.577864e-01 6 127981116 127981289 174 - 1.822 1.899 0.256
ENSG00000152894 E012 65.5361493 0.0004219475 2.574410e-01 3.945620e-01 6 127982831 127982980 150 - 1.782 1.847 0.219
ENSG00000152894 E013 60.2035225 0.0004041239 2.072668e-01 3.352322e-01 6 127983242 127983377 136 - 1.740 1.813 0.246
ENSG00000152894 E014 47.9027967 0.0004930050 5.868276e-01 7.102917e-01 6 127985721 127985820 100 - 1.655 1.698 0.144
ENSG00000152894 E015 37.9853500 0.0005241695 4.867777e-01 6.244994e-01 6 127985821 127985875 55 - 1.580 1.553 -0.095
ENSG00000152894 E016 44.1601377 0.0007225206 1.567191e-02 4.200557e-02 6 127990769 127990859 91 - 1.678 1.552 -0.426
ENSG00000152894 E017 32.0625637 0.0035309428 6.742925e-02 1.390844e-01 6 127990860 127990885 26 - 1.539 1.422 -0.403
ENSG00000152894 E018 50.1052974 0.0006374482 1.047535e-01 1.977463e-01 6 127991294 127991391 98 - 1.712 1.639 -0.248
ENSG00000152894 E019 33.6258735 0.0006520804 7.009873e-02 1.435334e-01 6 127992673 127992709 37 - 1.550 1.445 -0.358
ENSG00000152894 E020 0.0000000       6 127995249 127995266 18 -      
ENSG00000152894 E021 35.6170290 0.0006149805 7.425084e-01 8.313831e-01 6 127995462 127995538 77 - 1.531 1.564 0.115
ENSG00000152894 E022 38.9255225 0.0008581230 5.651494e-01 6.923063e-01 6 127996901 127996988 88 - 1.585 1.565 -0.071
ENSG00000152894 E023 59.6864991 0.0010042283 4.065323e-01 5.501560e-01 6 127998720 127998904 185 - 1.773 1.746 -0.092
ENSG00000152894 E024 0.2966881 0.0270551987 5.118743e-01   6 127999987 128000330 344 - 0.156 0.000 -10.221
ENSG00000152894 E025 0.0000000       6 128001196 128001207 12 -      
ENSG00000152894 E026 0.5985731 0.0201481015 7.884292e-01 8.645791e-01 6 128003197 128003232 36 - 0.218 0.173 -0.414
ENSG00000152894 E027 0.0000000       6 128004977 128005083 107 -      
ENSG00000152894 E028 44.8075495 0.0045236747 4.997334e-01 6.360082e-01 6 128005084 128005244 161 - 1.621 1.676 0.187
ENSG00000152894 E029 0.1472490 0.0428318398 1.000000e+00   6 128006026 128006055 30 - 0.085 0.000 -9.221
ENSG00000152894 E030 0.0000000       6 128008046 128008087 42 -      
ENSG00000152894 E031 40.8963716 0.0039692262 6.836315e-01 7.867757e-01 6 128009130 128009265 136 - 1.602 1.588 -0.047
ENSG00000152894 E032 17.4621991 0.0010384378 4.002885e-02 9.108796e-02 6 128009266 128009268 3 - 1.293 1.121 -0.609
ENSG00000152894 E033 1.1405380 0.3783678855 1.837566e-01 3.059250e-01 6 128062066 128062424 359 - 0.156 0.488 2.260
ENSG00000152894 E034 0.1472490 0.0428318398 1.000000e+00   6 128063436 128063525 90 - 0.085 0.000 -9.221
ENSG00000152894 E035 24.7098023 0.0009698146 5.020104e-02 1.095130e-01 6 128064758 128064794 37 - 1.428 1.292 -0.473
ENSG00000152894 E036 63.3359955 0.0017788831 1.715335e-04 8.416821e-04 6 128067519 128067792 274 - 1.845 1.662 -0.617
ENSG00000152894 E037 45.8521362 0.0021951565 5.098341e-03 1.619900e-02 6 128078813 128078918 106 - 1.701 1.546 -0.525
ENSG00000152894 E038 61.7197387 0.0024065432 2.597163e-03 9.057225e-03 6 128082437 128082638 202 - 1.824 1.676 -0.500
ENSG00000152894 E039 38.7418938 0.0005566459 1.111617e-04 5.731034e-04 6 128083715 128083824 110 - 1.645 1.414 -0.791
ENSG00000152894 E040 74.9664229 0.0004780968 2.993739e-04 1.377091e-03 6 128089690 128089992 303 - 1.906 1.757 -0.501
ENSG00000152894 E041 59.0558650 0.0004433938 1.089415e-02 3.091124e-02 6 128184432 128184572 141 - 1.793 1.681 -0.381
ENSG00000152894 E042 64.6770837 0.0004517052 1.477283e-08 1.764830e-07 6 128184573 128184725 153 - 1.873 1.603 -0.914
ENSG00000152894 E043 55.3967699 0.0081585250 2.325425e-05 1.420196e-04 6 128218922 128219069 148 - 1.810 1.528 -0.958
ENSG00000152894 E044 25.6405966 0.0008864521 2.098483e-04 1.005950e-03 6 128219070 128219096 27 - 1.484 1.208 -0.960
ENSG00000152894 E045 0.0000000       6 128230732 128230865 134 -      
ENSG00000152894 E046 0.0000000       6 128232090 128232151 62 -      
ENSG00000152894 E047 0.8136755 0.0145966067 6.884946e-01 7.906051e-01 6 128235380 128235604 225 - 0.218 0.296 0.588
ENSG00000152894 E048 40.5392486 0.0103688164 8.768317e-04 3.533119e-03 6 128240035 128240150 116 - 1.672 1.421 -0.858
ENSG00000152894 E049 0.0000000       6 128241223 128241299 77 -      
ENSG00000152894 E050 36.0825501 0.0005720923 7.816265e-04 3.193513e-03 6 128242521 128242602 82 - 1.609 1.405 -0.699
ENSG00000152894 E051 3.0988567 0.0051843921 5.215417e-03 1.651697e-02 6 128321041 128321402 362 - 0.401 0.836 1.949
ENSG00000152894 E052 19.0544476 0.0124917210 2.555458e-04 1.198356e-03 6 128321403 128322038 636 - 1.126 1.480 1.242
ENSG00000152894 E053 75.6395746 0.0003931187 2.908931e-02 7.017462e-02 6 128322039 128322250 212 - 1.888 1.807 -0.275
ENSG00000152894 E054 47.1669876 0.0004838694 9.811025e-02 1.876422e-01 6 128322251 128322310 60 - 1.685 1.608 -0.262
ENSG00000152894 E055 54.9954154 0.0007667970 5.343095e-03 1.686578e-02 6 128397566 128397688 123 - 1.767 1.634 -0.450
ENSG00000152894 E056 2.5444839 0.0070536421 5.802218e-01 7.049941e-01 6 128409294 128409332 39 - 0.556 0.471 -0.411
ENSG00000152894 E057 1.6908520 0.0114033699 7.341505e-01 8.251843e-01 6 128491732 128491849 118 - 0.401 0.470 0.364
ENSG00000152894 E058 0.0000000       6 128491850 128491857 8 -      
ENSG00000152894 E059 3.8526515 0.0362165545 8.811105e-09 1.097316e-07 6 128518928 128519141 214 - 0.085 1.051 5.562
ENSG00000152894 E060 60.2992537 0.0004321791 2.237570e-02 5.645781e-02 6 128520259 128520616 358 - 1.796 1.698 -0.332