ENSG00000152795

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000507721 ENSG00000152795 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPDL protein_coding protein_coding 179.5313 160.7176 264.4315 7.17283 10.05755 0.7183312 45.921173 19.204708 58.56113 2.563434 1.5856453 1.6079788 0.27009583 0.11890000 0.22223333 0.103333333 5.450033e-04 1.720788e-39 FALSE TRUE
ENST00000602300 ENSG00000152795 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPDL protein_coding protein_coding 179.5313 160.7176 264.4315 7.17283 10.05755 0.7183312 7.633277 0.000000 19.19317 0.000000 2.3374278 10.9071287 0.03860417 0.00000000 0.07283333 0.072833333 1.720788e-39 1.720788e-39 FALSE TRUE
ENST00000621267 ENSG00000152795 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPDL protein_coding protein_coding 179.5313 160.7176 264.4315 7.17283 10.05755 0.7183312 13.667517 13.339225 20.83427 1.498375 1.4162278 0.6428951 0.07516667 0.08266667 0.07860000 -0.004066667 8.849093e-01 1.720788e-39 FALSE TRUE
ENST00000630114 ENSG00000152795 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPDL protein_coding nonsense_mediated_decay 179.5313 160.7176 264.4315 7.17283 10.05755 0.7183312 17.860296 8.602451 24.12127 3.345173 0.9891547 1.4864082 0.10331667 0.05206667 0.09120000 0.039133333 2.278351e-01 1.720788e-39 TRUE TRUE
ENST00000630827 ENSG00000152795 HEK293_OSMI2_2hA HEK293_TMG_2hB HNRNPDL protein_coding protein_coding 179.5313 160.7176 264.4315 7.17283 10.05755 0.7183312 87.144277 110.505019 135.17199 3.405902 9.7358718 0.2906606 0.47061667 0.68866667 0.50983333 -0.178833333 3.638211e-06 1.720788e-39 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152795 E001 0.00000       4 82422565 82422568 4 -      
ENSG00000152795 E002 1143.24160 0.0038471917 2.587252e-01 3.960401e-01 4 82422569 82424624 2056 - 3.047 3.070 0.078
ENSG00000152795 E003 104.96601 0.0004749343 4.210100e-04 1.854992e-03 4 82424625 82424628 4 - 1.973 2.085 0.378
ENSG00000152795 E004 105.24233 0.0008600814 2.936205e-05 1.751158e-04 4 82424629 82424629 1 - 1.959 2.100 0.474
ENSG00000152795 E005 106.58834 0.0003014495 1.522811e-06 1.215932e-05 4 82424630 82424630 1 - 1.957 2.111 0.516
ENSG00000152795 E006 1732.47719 0.0023769765 5.946813e-09 7.661380e-08 4 82424631 82424883 253 - 3.176 3.302 0.419
ENSG00000152795 E007 732.79181 0.0071805644 2.136072e-05 1.315623e-04 4 82424884 82425562 679 - 2.941 2.749 -0.639
ENSG00000152795 E008 255.34816 0.0020766074 3.476333e-14 1.056095e-12 4 82425563 82425582 20 - 2.506 2.246 -0.865
ENSG00000152795 E009 428.15417 0.0035632781 1.526708e-09 2.187493e-08 4 82425583 82425667 85 - 2.717 2.497 -0.735
ENSG00000152795 E010 472.93207 0.0096677496 1.305925e-11 2.669150e-10 4 82425668 82426036 369 - 2.802 2.443 -1.194
ENSG00000152795 E011 1972.52037 0.0008234710 4.175828e-06 3.023035e-05 4 82426037 82426129 93 - 3.268 3.324 0.187
ENSG00000152795 E012 2414.01534 0.0008667502 1.885075e-03 6.868123e-03 4 82426463 82426633 171 - 3.367 3.399 0.109
ENSG00000152795 E013 1660.73780 0.0001613775 2.284961e-06 1.754891e-05 4 82427190 82427304 115 - 3.205 3.239 0.116
ENSG00000152795 E014 1910.80262 0.0010828795 1.421822e-01 2.510087e-01 4 82427433 82427564 132 - 3.276 3.284 0.025
ENSG00000152795 E015 2310.73926 0.0023289975 5.236444e-01 6.572782e-01 4 82428018 82428179 162 - 3.364 3.360 -0.012
ENSG00000152795 E016 2354.63171 0.0017678144 7.025713e-03 2.129192e-02 4 82428278 82428446 169 - 3.401 3.330 -0.237
ENSG00000152795 E017 1518.15450 0.0027601432 1.699593e-04 8.348876e-04 4 82429248 82429412 165 - 3.229 3.113 -0.384
ENSG00000152795 E018 645.58342 0.0067528933 7.802028e-02 1.562922e-01 4 82429413 82430341 929 - 2.848 2.756 -0.307
ENSG00000152795 E019 12.18881 0.0042630858 3.282606e-01 4.717501e-01 4 82430342 82430568 227 - 1.073 1.156 0.298