ENSG00000152700

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000402673 ENSG00000152700 HEK293_OSMI2_2hA HEK293_TMG_2hB SAR1B protein_coding protein_coding 29.27858 12.74521 40.13605 0.6700633 1.60075 1.654172 5.626467 3.255592 8.939625 0.3197243 0.29338190 1.4544827 0.2187167 0.2543333 0.22293333 -0.0314000 4.419153e-01 9.883535e-21 FALSE TRUE
ENST00000439578 ENSG00000152700 HEK293_OSMI2_2hA HEK293_TMG_2hB SAR1B protein_coding protein_coding 29.27858 12.74521 40.13605 0.6700633 1.60075 1.654172 21.172840 6.827878 29.403065 0.2806566 1.36209773 2.1048365 0.6309125 0.5364667 0.73220000 0.1957333 3.161391e-12 9.883535e-21 FALSE TRUE
MSTRG.26941.3 ENSG00000152700 HEK293_OSMI2_2hA HEK293_TMG_2hB SAR1B protein_coding   29.27858 12.74521 40.13605 0.6700633 1.60075 1.654172 1.734272 1.925014 1.326734 0.1780638 0.05539588 -0.5336319 0.1012000 0.1504333 0.03303333 -0.1174000 9.883535e-21 9.883535e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152700 E001 686.0554905 0.0007393183 2.473240e-03 8.683244e-03 5 134601149 134606428 5280 - 2.793 2.846 0.178
ENSG00000152700 E002 26.6594299 0.0007319285 4.115846e-01 5.551254e-01 5 134606429 134606429 1 - 1.432 1.375 -0.195
ENSG00000152700 E003 155.6476436 0.0002259840 3.198081e-06 2.377907e-05 5 134606430 134606737 308 - 2.118 2.258 0.470
ENSG00000152700 E004 82.2369191 0.0003378702 6.348033e-05 3.484833e-04 5 134606738 134606801 64 - 1.834 1.999 0.554
ENSG00000152700 E005 197.8052115 0.0001851165 3.755796e-02 8.650961e-02 5 134606802 134606948 147 - 2.252 2.311 0.196
ENSG00000152700 E006 152.3220643 0.0002355238 8.500724e-01 9.069970e-01 5 134606949 134606986 38 - 2.157 2.166 0.032
ENSG00000152700 E007 126.0086357 0.0002925714 7.251740e-01 8.185103e-01 5 134606987 134606989 3 - 2.081 2.073 -0.028
ENSG00000152700 E008 179.3330038 0.0002347829 3.195956e-01 4.626844e-01 5 134606990 134607036 47 - 2.236 2.211 -0.084
ENSG00000152700 E009 164.9610536 0.0002513380 6.064677e-02 1.277204e-01 5 134607037 134607066 30 - 2.209 2.156 -0.178
ENSG00000152700 E010 256.0669178 0.0002594064 3.326356e-03 1.122434e-02 5 134608372 134608503 132 - 2.403 2.334 -0.228
ENSG00000152700 E011 0.0000000       5 134608976 134609133 158 -      
ENSG00000152700 E012 157.7620917 0.0002442504 2.540481e-03 8.884742e-03 5 134609571 134609609 39 - 2.200 2.109 -0.303
ENSG00000152700 E013 180.6015824 0.0002185863 1.872583e-02 4.873546e-02 5 134609610 134609674 65 - 2.251 2.187 -0.213
ENSG00000152700 E014 201.0630938 0.0002117657 9.886344e-02 1.887396e-01 5 134612691 134612756 66 - 2.292 2.251 -0.136
ENSG00000152700 E015 1.3994745 0.0098466375 9.673978e-02 1.854928e-01 5 134612757 134613009 253 - 0.260 0.554 1.654
ENSG00000152700 E016 0.2924217 0.0275801928 6.028886e-01   5 134613010 134613013 4 - 0.149 0.000 -11.501
ENSG00000152700 E017 1.2459845 0.0143568479 5.907156e-01 7.135454e-01 5 134613014 134613075 62 - 0.306 0.406 0.597
ENSG00000152700 E018 6.2441909 0.0047814498 8.058911e-02 1.604726e-01 5 134613076 134614903 1828 - 0.741 0.967 0.876
ENSG00000152700 E019 0.1451727 0.0436323636 1.000000e+00   5 134618192 134618313 122 - 0.081 0.000 -10.494
ENSG00000152700 E020 174.4379391 0.0002164577 6.097661e-04 2.568673e-03 5 134620933 134621001 69 - 2.246 2.148 -0.327
ENSG00000152700 E021 112.5037895 0.0002936517 2.108678e-04 1.010377e-03 5 134621002 134621052 51 - 2.066 1.931 -0.454
ENSG00000152700 E022 123.9474761 0.0009116477 7.211086e-03 2.177290e-02 5 134623962 134624037 76 - 2.099 2.003 -0.323
ENSG00000152700 E023 0.1817044 0.0432690915 1.889255e-01   5 134625777 134625876 100 - 0.000 0.181 11.930
ENSG00000152700 E024 4.6339375 0.0131673948 4.733435e-05 2.682506e-04 5 134631602 134632076 475 - 0.454 1.033 2.410
ENSG00000152700 E025 13.9738185 0.0012949586 3.180379e-03 1.079850e-02 5 134632077 134632195 119 - 1.043 1.315 0.967
ENSG00000152700 E026 0.2214452 0.0413882693 1.886422e-01   5 134632196 134632199 4 - 0.000 0.181 11.961
ENSG00000152700 E027 91.7766515 0.0068832309 8.288183e-02 1.640611e-01 5 134632728 134632828 101 - 1.968 1.871 -0.327
ENSG00000152700 E028 39.2175684 0.0005821866 1.639477e-26 2.035348e-24 5 134648116 134649271 1156 - 1.284 1.889 2.067