ENSG00000152642

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282541 ENSG00000152642 HEK293_OSMI2_2hA HEK293_TMG_2hB GPD1L protein_coding protein_coding 12.79318 8.703387 15.05987 1.963832 0.4354533 0.7903618 10.049247 4.929667 13.2337135 0.7271299 0.3184781 1.422822 0.7415917 0.5849667 0.87993333 0.2949667 6.044808e-05 6.044808e-05 FALSE TRUE
ENST00000496151 ENSG00000152642 HEK293_OSMI2_2hA HEK293_TMG_2hB GPD1L protein_coding retained_intron 12.79318 8.703387 15.05987 1.963832 0.4354533 0.7903618 1.598842 3.388342 0.5096906 1.0791070 0.5096906 -2.709106 0.1759667 0.3746000 0.03263333 -0.3419667 2.652843e-02 6.044808e-05 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152642 E001 0.0000000       3 32105689 32105829 141 +      
ENSG00000152642 E002 0.9545818 0.0153401582 8.038627e-01 8.752061e-01 3 32106612 32106619 8 + 0.289 0.278 -0.072
ENSG00000152642 E003 1.6167550 0.0096323824 9.086607e-01 9.459761e-01 3 32106620 32106632 13 + 0.383 0.447 0.343
ENSG00000152642 E004 19.4128450 0.0155971324 7.214695e-03 2.178206e-02 3 32106633 32106698 66 + 1.374 1.159 -0.756
ENSG00000152642 E005 28.4559558 0.0022680615 5.298828e-05 2.967153e-04 3 32106699 32106758 60 + 1.538 1.316 -0.765
ENSG00000152642 E006 0.1817044 0.0492783978 2.977123e-01   3 32106759 32106817 59 + 0.000 0.161 10.105
ENSG00000152642 E007 63.6699658 0.0009916331 1.815701e-06 1.425702e-05 3 32128076 32128253 178 + 1.859 1.702 -0.531
ENSG00000152642 E008 62.0906506 0.0041741384 4.199091e-03 1.370096e-02 3 32138587 32138727 141 + 1.828 1.737 -0.308
ENSG00000152642 E009 77.5409303 0.0003826679 1.368747e-03 5.204835e-03 3 32140228 32140366 139 + 1.912 1.854 -0.197
ENSG00000152642 E010 67.8245893 0.0004014890 1.079754e-02 3.068005e-02 3 32146622 32146734 113 + 1.849 1.811 -0.129
ENSG00000152642 E011 2.0860751 0.1961773164 5.341918e-01 6.662872e-01 3 32158334 32158756 423 + 0.425 0.564 0.680
ENSG00000152642 E012 1.8111463 0.0078415531 7.166468e-01 8.122455e-01 3 32158757 32158875 119 + 0.461 0.446 -0.075
ENSG00000152642 E013 100.9121922 0.0012765644 8.908336e-07 7.478100e-06 3 32158876 32159109 234 + 2.045 1.921 -0.417
ENSG00000152642 E014 83.6891635 0.0026592177 1.203081e-05 7.845787e-05 3 32159568 32159674 107 + 1.970 1.835 -0.454
ENSG00000152642 E015 887.4428458 0.0021577149 1.926353e-18 1.025117e-16 3 32165814 32168709 2896 + 2.873 3.031 0.523