ENSG00000152620

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282512 ENSG00000152620 HEK293_OSMI2_2hA HEK293_TMG_2hB NADK2 protein_coding protein_coding 12.27208 4.941193 17.32012 0.3091027 0.3338901 1.807434 3.0943282 0.4791788 4.655461 0.4791788 0.3168484 3.2535858 0.20981667 0.10796667 0.2689333 0.1609667 1.880628e-01 2.18334e-17 FALSE TRUE
ENST00000381937 ENSG00000152620 HEK293_OSMI2_2hA HEK293_TMG_2hB NADK2 protein_coding protein_coding 12.27208 4.941193 17.32012 0.3091027 0.3338901 1.807434 1.2846345 1.1208535 2.125794 0.3070100 0.0773152 0.9173605 0.13876667 0.23313333 0.1229667 -0.1101667 3.508683e-01 2.18334e-17 FALSE TRUE
ENST00000502355 ENSG00000152620 HEK293_OSMI2_2hA HEK293_TMG_2hB NADK2 protein_coding protein_coding 12.27208 4.941193 17.32012 0.3091027 0.3338901 1.807434 0.2712247 0.4587601 0.000000 0.4587601 0.0000000 -5.5507779 0.03360000 0.09400000 0.0000000 -0.0940000 6.396687e-01 2.18334e-17 FALSE FALSE
ENST00000511613 ENSG00000152620 HEK293_OSMI2_2hA HEK293_TMG_2hB NADK2 protein_coding processed_transcript 12.27208 4.941193 17.32012 0.3091027 0.3338901 1.807434 2.6341735 0.3003750 3.147191 0.3003750 0.3463271 3.3465575 0.20180833 0.06766667 0.1826000 0.1149333 2.028875e-01 2.18334e-17   FALSE
ENST00000514504 ENSG00000152620 HEK293_OSMI2_2hA HEK293_TMG_2hB NADK2 protein_coding protein_coding 12.27208 4.941193 17.32012 0.3091027 0.3338901 1.807434 1.7681783 0.0000000 3.156583 0.0000000 0.2514807 8.3067832 0.09583333 0.00000000 0.1823000 0.1823000 2.183340e-17 2.18334e-17 FALSE TRUE
MSTRG.26068.3 ENSG00000152620 HEK293_OSMI2_2hA HEK293_TMG_2hB NADK2 protein_coding   12.27208 4.941193 17.32012 0.3091027 0.3338901 1.807434 2.4847455 2.0480659 3.208506 1.0963051 0.2214192 0.6451021 0.25747083 0.39060000 0.1849000 -0.2057000 8.730762e-01 2.18334e-17 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152620 E001 0.0000000       5 36192589 36192591 3 -      
ENSG00000152620 E002 1.5144556 0.0091320969 3.065148e-03 0.0104586122 5 36192592 36192884 293 - 0.149 0.665 3.145
ENSG00000152620 E003 111.4735499 0.0237420824 1.275912e-04 0.0006481581 5 36192885 36193712 828 - 1.885 2.224 1.135
ENSG00000152620 E004 189.4820267 0.0002251218 1.068484e-02 0.0304173116 5 36193713 36194821 1109 - 2.224 2.311 0.290
ENSG00000152620 E005 74.3293547 0.0004227496 7.891376e-01 0.8650139891 5 36194822 36194985 164 - 1.840 1.872 0.108
ENSG00000152620 E006 31.5351766 0.0006865273 9.109490e-01 0.9474211985 5 36194986 36194987 2 - 1.478 1.506 0.095
ENSG00000152620 E007 65.6248062 0.0004163162 5.036260e-01 0.6395947417 5 36194988 36195061 74 - 1.799 1.789 -0.035
ENSG00000152620 E008 75.3375019 0.0003862252 7.021313e-01 0.8010013428 5 36195062 36195143 82 - 1.855 1.860 0.016
ENSG00000152620 E009 97.2782056 0.0004132467 6.573460e-01 0.7667012930 5 36195144 36195282 139 - 1.952 1.990 0.126
ENSG00000152620 E010 84.5621322 0.0003402437 7.412253e-01 0.8304723915 5 36197541 36197664 124 - 1.896 1.931 0.116
ENSG00000152620 E011 61.4174580 0.0024225395 3.283562e-01 0.4718410072 5 36200227 36200280 54 - 1.781 1.750 -0.103
ENSG00000152620 E012 59.2646469 0.0044252939 4.113427e-01 0.5549096991 5 36201106 36201161 56 - 1.764 1.734 -0.102
ENSG00000152620 E013 70.8309928 0.0053218055 9.842436e-01 0.9942465302 5 36207170 36207265 96 - 1.826 1.842 0.052
ENSG00000152620 E014 4.5855090 0.0040867585 7.441756e-01 0.8325914442 5 36208625 36208690 66 - 0.741 0.711 -0.122
ENSG00000152620 E015 61.2699792 0.0012841687 7.103230e-02 0.1450561202 5 36211844 36211922 79 - 1.792 1.722 -0.239
ENSG00000152620 E016 0.2987644 0.0275465232 5.866155e-01   5 36212264 36212313 50 - 0.149 0.000 -9.770
ENSG00000152620 E017 0.5911862 0.0172671820 2.072355e-01 0.3352158342 5 36213013 36213177 165 - 0.260 0.000 -10.747
ENSG00000152620 E018 51.1731695 0.0010957610 5.821868e-01 0.7065977661 5 36217748 36217793 46 - 1.698 1.691 -0.026
ENSG00000152620 E019 75.0241433 0.0003403811 4.115706e-01 0.5551223465 5 36217794 36217884 91 - 1.861 1.847 -0.048
ENSG00000152620 E020 0.4470576 0.0213925111 8.893679e-01 0.9332917034 5 36217885 36218257 373 - 0.149 0.181 0.336
ENSG00000152620 E021 68.4161784 0.0003739835 1.166638e-01 0.2151991992 5 36219596 36219679 84 - 1.832 1.782 -0.170
ENSG00000152620 E022 69.6468465 0.0005621477 1.946202e-01 0.3195306003 5 36225542 36225623 82 - 1.835 1.796 -0.129
ENSG00000152620 E023 67.7553106 0.0004654598 1.518748e-03 0.0056969058 5 36226475 36226563 89 - 1.847 1.718 -0.438
ENSG00000152620 E024 47.4173350 0.0015303796 1.498388e-03 0.0056306818 5 36227477 36227565 89 - 1.707 1.539 -0.572
ENSG00000152620 E025 0.9514719 0.1623108244 3.142992e-02 0.0747464663 5 36241359 36241498 140 - 0.081 0.494 3.373
ENSG00000152620 E026 37.1655456 0.0091832630 2.520415e-05 0.0001526828 5 36241499 36241925 427 - 1.637 1.304 -1.149
ENSG00000152620 E027 4.4865216 0.0109985256 3.102013e-01 0.4525632755 5 36241963 36242095 133 - 0.757 0.613 -0.601
ENSG00000152620 E028 3.8217927 0.0423283228 1.883437e-01 0.3116448754 5 36242096 36242279 184 - 0.724 0.488 -1.050