ENSG00000152556

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359794 ENSG00000152556 HEK293_OSMI2_2hA HEK293_TMG_2hB PFKM protein_coding protein_coding 51.72599 58.73216 42.64207 5.504334 1.632785 -0.4617807 31.437901 43.023436 22.589566 4.2762410 1.1159146 -0.92916300 0.6003750 0.73170000 0.5319 -0.19980000 0.000385899 4.722857e-09 FALSE TRUE
ENST00000546964 ENSG00000152556 HEK293_OSMI2_2hA HEK293_TMG_2hB PFKM protein_coding retained_intron 51.72599 58.73216 42.64207 5.504334 1.632785 -0.4617807 6.149208 5.408969 5.647599 0.4085073 0.3526047 0.06217143 0.1212042 0.09426667 0.1325 0.03823333 0.231577637 4.722857e-09 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152556 E001 0.9599055 0.0210353444 4.707653e-01 6.099751e-01 12 48105139 48105419 281 + 0.363 0.238 -0.843
ENSG00000152556 E002 0.2987644 0.0273939906 8.385252e-02   12 48105482 48105620 139 + 0.272 0.000 -13.233
ENSG00000152556 E003 1.6649269 0.0081333665 7.632453e-01 8.466168e-01 12 48105621 48105717 97 + 0.438 0.391 -0.258
ENSG00000152556 E004 1.5970734 0.0143073174 3.513158e-01 4.955307e-01 12 48105718 48105810 93 + 0.502 0.345 -0.844
ENSG00000152556 E005 0.7029582 0.0168641282 6.627227e-01 7.709717e-01 12 48105911 48105922 12 + 0.157 0.238 0.743
ENSG00000152556 E006 13.3323775 0.0015948981 5.100834e-02 1.109623e-01 12 48105923 48106105 183 + 1.234 1.059 -0.625
ENSG00000152556 E007 8.0986430 0.0149834921 7.490723e-01 8.361242e-01 12 48106106 48106106 1 + 0.947 0.908 -0.145
ENSG00000152556 E008 9.1262776 0.0171187322 2.562423e-01 3.932148e-01 12 48106107 48106115 9 + 1.059 0.921 -0.511
ENSG00000152556 E009 7.9846954 0.0028296100 8.265820e-02 1.637117e-01 12 48106116 48106117 2 + 1.042 0.850 -0.721
ENSG00000152556 E010 10.8790337 0.0018055376 3.237209e-02 7.657762e-02 12 48106118 48106137 20 + 1.174 0.967 -0.754
ENSG00000152556 E011 0.9566712 0.2800933908 2.309968e-01 3.636694e-01 12 48106138 48106143 6 + 0.438 0.173 -1.835
ENSG00000152556 E012 1.2564799 0.0473178711 1.415430e-01 2.501390e-01 12 48106144 48106156 13 + 0.502 0.238 -1.582
ENSG00000152556 E013 1.9196841 0.0076958678 3.054511e-01 4.475597e-01 12 48106157 48106181 25 + 0.558 0.390 -0.843
ENSG00000152556 E014 1.1394067 0.0109752102 6.856563e-01 7.883408e-01 12 48106182 48106218 37 + 0.363 0.295 -0.427
ENSG00000152556 E015 2.0627805 0.0069530998 1.799129e-01 3.010755e-01 12 48106219 48106252 34 + 0.607 0.390 -1.065
ENSG00000152556 E016 2.9797970 0.0053636948 2.125735e-01 3.415842e-01 12 48106253 48106311 59 + 0.692 0.504 -0.841
ENSG00000152556 E017 1.1782197 0.0108647759 1.020176e-04 5.312660e-04 12 48106388 48106535 148 + 0.652 0.000 -15.644
ENSG00000152556 E018 16.1665283 0.0047959370 9.835372e-04 3.903369e-03 12 48107365 48107455 91 + 1.374 1.086 -1.017
ENSG00000152556 E019 23.3016504 0.0084960463 4.075189e-04 1.803403e-03 12 48108072 48108194 123 + 1.528 1.239 -1.002
ENSG00000152556 E020 2.2475908 0.0090019540 7.271082e-01 8.199409e-01 12 48118482 48118577 96 + 0.438 0.504 0.329
ENSG00000152556 E021 2.0261707 0.0235743524 1.682165e-01 2.858896e-01 12 48119264 48119326 63 + 0.272 0.535 1.476
ENSG00000152556 E022 3.1290457 0.0050210538 7.343813e-01 8.253523e-01 12 48119327 48119342 16 + 0.558 0.619 0.272
ENSG00000152556 E023 3.2407054 0.0051838794 3.311190e-01 4.747048e-01 12 48119343 48119347 5 + 0.502 0.666 0.740
ENSG00000152556 E024 5.1584124 0.0032420603 4.631215e-01 6.029536e-01 12 48119348 48119350 3 + 0.692 0.802 0.446
ENSG00000152556 E025 6.7720324 0.0024508817 9.590957e-01 9.783638e-01 12 48119351 48119351 1 + 0.851 0.865 0.051
ENSG00000152556 E026 42.9185329 0.0005136043 2.684163e-01 4.068705e-01 12 48119352 48119363 12 + 1.653 1.601 -0.179
ENSG00000152556 E027 110.2170582 0.0002653234 6.745556e-01 7.800496e-01 12 48119364 48119390 27 + 2.025 2.019 -0.021
ENSG00000152556 E028 132.3620098 0.0002346988 7.038088e-01 8.024461e-01 12 48119391 48119406 16 + 2.102 2.098 -0.013
ENSG00000152556 E029 1.4769060 0.2864599936 6.476804e-01 7.593079e-01 12 48119407 48119462 56 + 0.439 0.345 -0.531
ENSG00000152556 E030 1.5272454 0.0539285674 7.648582e-03 2.289644e-02 12 48119787 48119929 143 + 0.652 0.172 -2.848
ENSG00000152556 E031 0.0000000       12 48122574 48122646 73 +      
ENSG00000152556 E032 0.0000000       12 48122647 48122653 7 +      
ENSG00000152556 E033 0.1482932 0.0410312600 8.317454e-01   12 48122654 48122677 24 + 0.000 0.094 10.141
ENSG00000152556 E034 0.0000000       12 48122678 48122719 42 +      
ENSG00000152556 E035 0.3299976 0.0274424043 4.175835e-01   12 48122720 48122766 47 + 0.000 0.172 11.317
ENSG00000152556 E036 261.4309699 0.0002567826 6.655184e-05 3.634385e-04 12 48122767 48122859 93 + 2.448 2.363 -0.283
ENSG00000152556 E037 0.8973375 0.0700032249 2.284254e-02 5.741380e-02 12 48125325 48125562 238 + 0.503 0.094 -3.172
ENSG00000152556 E038 258.6123147 0.0006431736 1.434914e-04 7.186977e-04 12 48130363 48130436 74 + 2.446 2.357 -0.296
ENSG00000152556 E039 273.5968802 0.0002589913 2.827421e-06 2.128707e-05 12 48131316 48131393 78 + 2.478 2.379 -0.328
ENSG00000152556 E040 1.4424375 0.0093764849 2.231283e-01 3.541274e-01 12 48131394 48131678 285 + 0.502 0.295 -1.165
ENSG00000152556 E041 0.8836079 0.0130851589 8.789176e-04 3.540314e-03 12 48131679 48131920 242 + 0.558 0.000 -15.165
ENSG00000152556 E042 1.6262182 0.0101423343 3.511960e-01 4.954069e-01 12 48132019 48132211 193 + 0.502 0.345 -0.843
ENSG00000152556 E043 473.4594701 0.0010770368 7.294542e-07 6.241494e-06 12 48132868 48133057 190 + 2.716 2.610 -0.353
ENSG00000152556 E044 446.1356799 0.0009908378 1.179645e-05 7.709401e-05 12 48133315 48133480 166 + 2.683 2.590 -0.308
ENSG00000152556 E045 168.7109447 0.0027890110 5.225954e-02 1.131812e-01 12 48134232 48134238 7 + 2.246 2.178 -0.226
ENSG00000152556 E046 196.8375411 0.0041071811 2.492113e-01 3.849826e-01 12 48134239 48134276 38 + 2.295 2.253 -0.140
ENSG00000152556 E047 232.1336995 0.0018985346 6.961354e-01 7.965691e-01 12 48134721 48134788 68 + 2.343 2.336 -0.025
ENSG00000152556 E048 220.7273373 0.0027780983 9.457324e-02 1.822424e-01 12 48134789 48134829 41 + 2.353 2.296 -0.189
ENSG00000152556 E049 298.0108711 0.0003274308 7.540865e-04 3.094339e-03 12 48134943 48135038 96 + 2.494 2.426 -0.227
ENSG00000152556 E050 39.0329350 0.0007413707 4.680412e-14 1.395044e-12 12 48135039 48135290 252 + 1.807 1.391 -1.422
ENSG00000152556 E051 307.7488241 0.0008372812 1.130660e-04 5.819211e-04 12 48135291 48135383 93 + 2.521 2.434 -0.291
ENSG00000152556 E052 21.6010406 0.0136310642 1.509159e-06 1.206047e-05 12 48137357 48137720 364 + 1.575 1.146 -1.492
ENSG00000152556 E053 320.8604099 0.0001617713 2.247321e-04 1.069316e-03 12 48137721 48137790 70 + 2.528 2.459 -0.228
ENSG00000152556 E054 309.4851418 0.0001483494 1.871491e-02 4.871039e-02 12 48137791 48137846 56 + 2.492 2.451 -0.139
ENSG00000152556 E055 339.8529407 0.0001536781 6.568461e-02 1.361892e-01 12 48139285 48139349 65 + 2.525 2.496 -0.098
ENSG00000152556 E056 4.1661079 0.1305829118 5.690461e-02 1.212985e-01 12 48139350 48139504 155 + 0.924 0.528 -1.638
ENSG00000152556 E057 269.8553297 0.0001584377 9.044818e-01 9.431752e-01 12 48139849 48139912 64 + 2.399 2.410 0.037
ENSG00000152556 E058 243.3088919 0.0001836462 3.844648e-01 5.286070e-01 12 48140722 48140770 49 + 2.342 2.372 0.099
ENSG00000152556 E059 358.2352740 0.0003287324 9.064757e-01 9.445787e-01 12 48140771 48140871 101 + 2.526 2.532 0.020
ENSG00000152556 E060 248.3574504 0.0016108546 4.843794e-01 6.223962e-01 12 48141311 48141337 27 + 2.379 2.366 -0.044
ENSG00000152556 E061 284.2263315 0.0014681070 4.550003e-01 5.955728e-01 12 48141338 48141381 44 + 2.437 2.423 -0.048
ENSG00000152556 E062 2.2614142 0.0109723582 5.762771e-05 3.197644e-04 12 48141672 48141704 33 + 0.824 0.172 -3.544
ENSG00000152556 E063 3.6461254 0.0449545039 1.289455e-02 3.566805e-02 12 48141705 48141739 35 + 0.877 0.469 -1.748
ENSG00000152556 E064 320.3168989 0.0017922517 8.188075e-01 8.855130e-01 12 48141740 48141827 88 + 2.470 2.481 0.036
ENSG00000152556 E065 3.7950118 0.1019635269 5.736158e-02 1.220968e-01 12 48141828 48141913 86 + 0.879 0.501 -1.599
ENSG00000152556 E066 448.5804546 0.0007133526 3.448743e-02 8.068988e-02 12 48141914 48142066 153 + 2.588 2.639 0.170
ENSG00000152556 E067 5.6519370 0.0387083352 2.854058e-03 9.835248e-03 12 48142067 48142378 312 + 1.042 0.595 -1.773
ENSG00000152556 E068 541.1265253 0.0001330173 6.156002e-07 5.350443e-06 12 48142782 48142946 165 + 2.641 2.733 0.305
ENSG00000152556 E069 374.5114777 0.0001555395 4.890246e-05 2.762264e-04 12 48143753 48143814 62 + 2.484 2.574 0.299
ENSG00000152556 E070 526.3769552 0.0002282974 2.331840e-10 3.858841e-09 12 48144046 48144157 112 + 2.609 2.730 0.402
ENSG00000152556 E071 518.1544628 0.0011732244 3.084023e-08 3.461455e-07 12 48145031 48145130 100 + 2.590 2.726 0.453
ENSG00000152556 E072 530.3410734 0.0008313140 1.149202e-10 2.007680e-09 12 48145210 48145315 106 + 2.594 2.738 0.482
ENSG00000152556 E073 850.8636672 0.0021105877 4.368843e-11 8.188209e-10 12 48145564 48146404 841 + 2.778 2.948 0.565