ENSG00000152520

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380958 ENSG00000152520 HEK293_OSMI2_2hA HEK293_TMG_2hB PAN3 protein_coding protein_coding 5.860594 3.148838 8.74527 0.3682915 0.2241236 1.470758 0.98693174 0.38397736 1.7964499 0.07045035 0.07123122 2.196973 0.15531250 0.12953333 0.205900000 0.07636667 2.521987e-01 5.685048e-05 FALSE  
ENST00000399613 ENSG00000152520 HEK293_OSMI2_2hA HEK293_TMG_2hB PAN3 protein_coding protein_coding 5.860594 3.148838 8.74527 0.3682915 0.2241236 1.470758 3.81355543 2.22176711 5.1747973 0.18768803 0.20402597 1.216101 0.67175000 0.71306667 0.591433333 -0.12163333 2.597711e-01 5.685048e-05 FALSE  
ENST00000503791 ENSG00000152520 HEK293_OSMI2_2hA HEK293_TMG_2hB PAN3 protein_coding retained_intron 5.860594 3.148838 8.74527 0.3682915 0.2241236 1.470758 0.28271017 0.00000000 0.5578450 0.00000000 0.22072115 5.827425 0.03319583 0.00000000 0.063666667 0.06366667 4.531621e-03 5.685048e-05 FALSE  
MSTRG.8530.3 ENSG00000152520 HEK293_OSMI2_2hA HEK293_TMG_2hB PAN3 protein_coding   5.860594 3.148838 8.74527 0.3682915 0.2241236 1.470758 0.36005402 0.17817287 0.3959846 0.06363973 0.03810678 1.109366 0.07117917 0.06070000 0.045166667 -0.01553333 8.923566e-01 5.685048e-05 TRUE  
MSTRG.8530.4 ENSG00000152520 HEK293_OSMI2_2hA HEK293_TMG_2hB PAN3 protein_coding   5.860594 3.148838 8.74527 0.3682915 0.2241236 1.470758 0.06401781 0.31963732 0.0338824 0.31963732 0.03388240 -2.909165 0.01465000 0.08253333 0.004033333 -0.07850000 7.935192e-01 5.685048e-05 TRUE  
MSTRG.8530.5 ENSG00000152520 HEK293_OSMI2_2hA HEK293_TMG_2hB PAN3 protein_coding   5.860594 3.148838 8.74527 0.3682915 0.2241236 1.470758 0.30781016 0.02909746 0.7863106 0.02909746 0.08207078 4.348184 0.04448333 0.01003333 0.089866667 0.07983333 5.685048e-05 5.685048e-05 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152520 E001 0.6017953 0.1368841189 3.307305e-01 4.743191e-01 13 28138506 28138544 39 + 0.218 0.000 -10.462
ENSG00000152520 E002 3.0535353 0.0323202367 2.529104e-02 6.247309e-02 13 28138545 28138642 98 + 0.612 0.218 -2.247
ENSG00000152520 E003 14.0761848 0.0013764050 2.601940e-02 6.398444e-02 13 28138643 28139032 390 + 1.137 1.005 -0.478
ENSG00000152520 E004 10.5942281 0.0379997404 2.822275e-01 4.222013e-01 13 28139033 28139087 55 + 1.011 0.946 -0.240
ENSG00000152520 E005 24.9578026 0.0008940115 5.538545e-03 1.738770e-02 13 28174272 28174393 122 + 1.370 1.253 -0.409
ENSG00000152520 E006 24.3150244 0.0008123259 5.811654e-04 2.464025e-03 13 28176493 28176559 67 + 1.370 1.185 -0.650
ENSG00000152520 E007 27.5709502 0.0008900295 6.758009e-05 3.684590e-04 13 28177865 28177935 71 + 1.424 1.203 -0.771
ENSG00000152520 E008 14.5068547 0.0230958637 5.435228e-02 1.168652e-01 13 28197185 28197346 162 + 1.152 1.005 -0.531
ENSG00000152520 E009 36.0174194 0.0122148780 5.863121e-03 1.825332e-02 13 28220231 28220378 148 + 1.523 1.390 -0.460
ENSG00000152520 E010 0.0000000       13 28239557 28239578 22 +      
ENSG00000152520 E011 5.5530710 0.0041752427 2.045142e-04 9.833154e-04 13 28239579 28239696 118 + 0.836 0.218 -3.170
ENSG00000152520 E012 0.4407149 0.0229414406 7.319004e-01 8.234727e-01 13 28239697 28240037 341 + 0.122 0.217 0.998
ENSG00000152520 E013 52.1594110 0.0177178487 6.611590e-05 3.613495e-04 13 28256292 28256539 248 + 1.698 1.446 -0.860
ENSG00000152520 E014 32.8283586 0.0069895255 2.480676e-04 1.167130e-03 13 28260447 28260551 105 + 1.499 1.298 -0.698
ENSG00000152520 E015 27.0893074 0.0007660847 4.258451e-04 1.873507e-03 13 28261401 28261458 58 + 1.413 1.237 -0.614
ENSG00000152520 E016 14.8360119 0.0051127334 2.982827e-03 1.021231e-02 13 28266715 28266717 3 + 1.176 0.945 -0.842
ENSG00000152520 E017 38.3209120 0.0005786658 1.896961e-05 1.182919e-04 13 28266718 28266876 159 + 1.560 1.376 -0.633
ENSG00000152520 E018 31.0491103 0.0016198346 2.223565e-02 5.616710e-02 13 28267095 28267211 117 + 1.445 1.388 -0.197
ENSG00000152520 E019 30.5598099 0.0055589280 9.849260e-01 9.946055e-01 13 28267300 28267401 102 + 1.397 1.509 0.386
ENSG00000152520 E020 38.6457621 0.0005782443 2.165843e-01 3.462902e-01 13 28270701 28270866 166 + 1.519 1.558 0.132
ENSG00000152520 E021 27.4578527 0.0007478087 4.661619e-03 1.498939e-02 13 28271981 28272071 91 + 1.408 1.298 -0.381
ENSG00000152520 E022 1.9123885 0.0112716408 1.331844e-02 3.666233e-02 13 28272072 28272313 242 + 0.493 0.000 -12.148
ENSG00000152520 E023 43.0740603 0.0005116955 1.662551e-02 4.411154e-02 13 28277237 28277376 140 + 1.581 1.550 -0.106
ENSG00000152520 E024 49.7000610 0.0024952766 4.540932e-05 2.584856e-04 13 28280412 28280541 130 + 1.664 1.517 -0.501
ENSG00000152520 E025 37.2386202 0.0005872456 5.847963e-05 3.238939e-04 13 28281315 28281379 65 + 1.544 1.376 -0.579
ENSG00000152520 E026 45.0705837 0.0011746623 1.377641e-01 2.449620e-01 13 28287984 28288122 139 + 1.588 1.616 0.095
ENSG00000152520 E027 62.1222074 0.0074408206 1.035549e-01 1.959152e-01 13 28292382 28292660 279 + 1.727 1.735 0.026
ENSG00000152520 E028 30.9470513 0.0006730310 1.967490e-03 7.124413e-03 13 28292661 28292768 108 + 1.457 1.339 -0.410
ENSG00000152520 E029 155.6769627 0.0039891039 4.092653e-02 9.274855e-02 13 28292769 28293862 1094 + 2.068 2.263 0.653
ENSG00000152520 E030 272.0315298 0.0114560574 2.982496e-21 2.197685e-19 13 28293863 28295335 1473 + 2.173 2.703 1.769