ENSG00000152503

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282369 ENSG00000152503 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM36 protein_coding protein_coding 1.957107 1.481376 2.612421 0.09032135 0.1808429 0.8142554 0.07364337 0.03581098 0.14927947 0.03581098 0.07125381 1.797795 0.05336250 0.02176667 0.061300000 0.03953333 6.681537e-01 6.717743e-05 FALSE TRUE
ENST00000379617 ENSG00000152503 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM36 protein_coding protein_coding 1.957107 1.481376 2.612421 0.09032135 0.1808429 0.8142554 0.08170256 0.19412511 0.01183619 0.05604701 0.01183619 -3.224661 0.06260833 0.12830000 0.004366667 -0.12393333 6.717743e-05 6.717743e-05 TRUE FALSE
ENST00000379618 ENSG00000152503 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM36 protein_coding protein_coding 1.957107 1.481376 2.612421 0.09032135 0.1808429 0.8142554 0.24690543 0.62020166 0.12099405 0.08662136 0.06049737 -2.266312 0.14742083 0.41536667 0.049033333 -0.36633333 9.242139e-04 6.717743e-05   FALSE
ENST00000513154 ENSG00000152503 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM36 protein_coding protein_coding 1.957107 1.481376 2.612421 0.09032135 0.1808429 0.8142554 1.23860436 0.63123839 2.06074398 0.06644028 0.20605060 1.691216 0.58665417 0.43453333 0.787833333 0.35330000 6.410333e-03 6.717743e-05 FALSE TRUE
ENST00000514154 ENSG00000152503 HEK293_OSMI2_2hA HEK293_TMG_2hB TRIM36 protein_coding protein_coding 1.957107 1.481376 2.612421 0.09032135 0.1808429 0.8142554 0.21263605 0.00000000 0.17876163 0.00000000 0.17876163 4.238494 0.10920417 0.00000000 0.065733333 0.06573333 8.987462e-01 6.717743e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152503 E001 0.1482932 0.042274838 1.681613e-01   5 115124762 115124771 10 - 0.000 0.197 11.910
ENSG00000152503 E002 51.7680493 0.020194599 4.049198e-02 9.192322e-02 5 115124772 115126502 1731 - 1.611 1.805 0.657
ENSG00000152503 E003 25.4394485 0.002327588 2.658325e-01 4.039331e-01 5 115126503 115126857 355 - 1.332 1.457 0.433
ENSG00000152503 E004 24.1294533 0.000809617 6.339047e-01 7.485125e-01 5 115130592 115130889 298 - 1.332 1.410 0.272
ENSG00000152503 E005 26.9674523 0.012312699 8.134431e-01 8.817047e-01 5 115133860 115134147 288 - 1.378 1.442 0.221
ENSG00000152503 E006 16.0332789 0.012368740 4.180735e-01 5.613711e-01 5 115137000 115137124 125 - 1.197 1.154 -0.154
ENSG00000152503 E007 19.5179693 0.002861713 3.951209e-03 1.300573e-02 5 115137363 115137616 254 - 1.320 1.097 -0.792
ENSG00000152503 E008 9.6838048 0.001865076 4.671572e-02 1.033208e-01 5 115141279 115141323 45 - 1.032 0.829 -0.765
ENSG00000152503 E009 11.4905095 0.016185428 1.287422e-02 3.562195e-02 5 115141324 115141374 51 - 1.113 0.830 -1.054
ENSG00000152503 E010 14.9944464 0.001404162 4.445376e-02 9.920991e-02 5 115144598 115144744 147 - 1.192 1.032 -0.575
ENSG00000152503 E011 0.1451727 0.043087478 1.000000e+00   5 115147068 115147068 1 - 0.073 0.000 -8.910
ENSG00000152503 E012 9.0064425 0.002450790 1.029766e-01 1.950061e-01 5 115147069 115147175 107 - 0.993 0.829 -0.622
ENSG00000152503 E013 14.2616941 0.001568229 4.393705e-04 1.925856e-03 5 115147176 115147394 219 - 1.212 0.865 -1.275
ENSG00000152503 E014 0.0000000       5 115153705 115153811 107 -      
ENSG00000152503 E015 0.0000000       5 115159641 115159670 30 -      
ENSG00000152503 E016 13.6859100 0.001516763 3.221480e-04 1.469433e-03 5 115163518 115163752 235 - 1.197 0.829 -1.359
ENSG00000152503 E017 0.1515154 0.042076584 1.000000e+00   5 115168967 115169086 120 - 0.073 0.000 -8.911
ENSG00000152503 E018 8.4262928 0.001970556 3.497593e-02 8.160649e-02 5 115169608 115169909 302 - 0.985 0.748 -0.914
ENSG00000152503 E019 0.0000000       5 115171102 115171105 4 -      
ENSG00000152503 E020 2.4636502 0.026716205 4.057476e-05 2.334984e-04 5 115171106 115171222 117 - 0.191 0.895 3.633
ENSG00000152503 E021 0.0000000       5 115174089 115174281 193 -      
ENSG00000152503 E022 2.9504461 0.058902450 1.667367e-07 1.623215e-06 5 115177123 115177872 750 - 0.073 1.006 5.632
ENSG00000152503 E023 9.7599421 0.049687106 3.083255e-08 3.460798e-07 5 115179975 115180546 572 - 0.575 1.406 3.149