ENSG00000152465

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378150 ENSG00000152465 HEK293_OSMI2_2hA HEK293_TMG_2hB NMT2 protein_coding protein_coding 14.41517 11.96811 18.63613 0.4825911 0.3724008 0.638476 3.9015324 2.8457352 5.5103343 0.2681303 0.4063801 0.9508934 0.26145000 0.23723333 0.29546667 0.058233333 3.640163e-01 1.199066e-13 FALSE TRUE
ENST00000378165 ENSG00000152465 HEK293_OSMI2_2hA HEK293_TMG_2hB NMT2 protein_coding protein_coding 14.41517 11.96811 18.63613 0.4825911 0.3724008 0.638476 1.2735583 0.9853127 1.6244685 0.1599827 0.1437515 0.7155999 0.09534167 0.08176667 0.08693333 0.005166667 9.338864e-01 1.199066e-13 FALSE TRUE
ENST00000466201 ENSG00000152465 HEK293_OSMI2_2hA HEK293_TMG_2hB NMT2 protein_coding processed_transcript 14.41517 11.96811 18.63613 0.4825911 0.3724008 0.638476 1.2060522 1.1912329 1.4970165 0.3377155 0.2153230 0.3271793 0.09776667 0.09966667 0.07993333 -0.019733333 8.776085e-01 1.199066e-13   FALSE
ENST00000486786 ENSG00000152465 HEK293_OSMI2_2hA HEK293_TMG_2hB NMT2 protein_coding processed_transcript 14.41517 11.96811 18.63613 0.4825911 0.3724008 0.638476 1.8274151 3.1792435 0.2763255 0.2842547 0.2763255 -3.4774859 0.14004583 0.26473333 0.01426667 -0.250466667 1.129920e-02 1.199066e-13 FALSE TRUE
MSTRG.3601.3 ENSG00000152465 HEK293_OSMI2_2hA HEK293_TMG_2hB NMT2 protein_coding   14.41517 11.96811 18.63613 0.4825911 0.3724008 0.638476 1.7468987 1.4789582 3.1590290 0.4472024 0.3487121 1.0897376 0.10857083 0.12520000 0.16953333 0.044333333 6.178301e-01 1.199066e-13 FALSE TRUE
MSTRG.3601.5 ENSG00000152465 HEK293_OSMI2_2hA HEK293_TMG_2hB NMT2 protein_coding   14.41517 11.96811 18.63613 0.4825911 0.3724008 0.638476 1.6039473 1.0779754 1.9244480 0.3156384 0.2738974 0.8302761 0.11140833 0.08866667 0.10390000 0.015233333 8.467874e-01 1.199066e-13 FALSE TRUE
MSTRG.3601.6 ENSG00000152465 HEK293_OSMI2_2hA HEK293_TMG_2hB NMT2 protein_coding   14.41517 11.96811 18.63613 0.4825911 0.3724008 0.638476 1.6955623 0.8275273 2.9259062 0.1609294 0.1975346 1.8095977 0.10410833 0.07043333 0.15746667 0.087033333 2.110138e-02 1.199066e-13 FALSE TRUE
MSTRG.3601.9 ENSG00000152465 HEK293_OSMI2_2hA HEK293_TMG_2hB NMT2 protein_coding   14.41517 11.96811 18.63613 0.4825911 0.3724008 0.638476 0.6584792 0.0000000 1.3353754 0.0000000 0.1652280 7.0718649 0.04172917 0.00000000 0.07156667 0.071566667 1.199066e-13 1.199066e-13 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152465 E001 10.4343287 0.0429290868 0.0253147877 0.062522790 10 15102584 15102809 226 - 0.888 1.214 1.192
ENSG00000152465 E002 44.4268352 0.0418424896 0.3834630532 0.527666263 10 15102810 15103683 874 - 1.600 1.713 0.383
ENSG00000152465 E003 3.6932546 0.0043439375 0.5849689629 0.708762040 10 15104937 15104945 9 - 0.711 0.631 -0.336
ENSG00000152465 E004 8.4708471 0.0022722138 0.7954073198 0.869357825 10 15104946 15105035 90 - 0.991 0.963 -0.101
ENSG00000152465 E005 17.2322844 0.0141429220 0.1262749470 0.228968595 10 15105770 15106039 270 - 1.190 1.338 0.522
ENSG00000152465 E006 18.0447624 0.0037071490 0.1450372649 0.254882792 10 15106040 15106235 196 - 1.218 1.340 0.430
ENSG00000152465 E007 23.1276546 0.0008465540 0.9438731692 0.968803179 10 15106236 15106372 137 - 1.380 1.387 0.022
ENSG00000152465 E008 14.2831089 0.0015669864 0.8823414836 0.928660024 10 15106373 15106400 28 - 1.197 1.185 -0.040
ENSG00000152465 E009 42.1129942 0.0033287535 0.0696160733 0.142719391 10 15106401 15106533 133 - 1.588 1.698 0.375
ENSG00000152465 E010 63.5482204 0.0003924487 0.0009656219 0.003840573 10 15106534 15106698 165 - 1.740 1.885 0.489
ENSG00000152465 E011 47.2403997 0.0024127695 0.9784175504 0.990645801 10 15106699 15108293 1595 - 1.682 1.685 0.012
ENSG00000152465 E012 132.0689630 0.0002628051 0.1637750107 0.280049503 10 15108294 15109039 746 - 2.105 2.148 0.144
ENSG00000152465 E013 58.1136864 0.0005726234 0.0008670041 0.003498133 10 15109040 15109215 176 - 1.832 1.675 -0.532
ENSG00000152465 E014 112.5240454 0.0002766317 0.0273839373 0.066773989 10 15109702 15109839 138 - 2.019 2.092 0.245
ENSG00000152465 E015 121.9641452 0.0003045165 0.0247041968 0.061270492 10 15112796 15112963 168 - 2.055 2.126 0.240
ENSG00000152465 E016 101.6769998 0.0003253838 0.6323868709 0.747255859 10 15119343 15119513 171 - 2.002 2.020 0.059
ENSG00000152465 E017 99.1422781 0.0007423883 0.3361109019 0.479933688 10 15128350 15128458 109 - 2.012 1.977 -0.118
ENSG00000152465 E018 98.8711292 0.0003422256 0.3347407665 0.478470002 10 15130142 15130312 171 - 2.012 1.979 -0.112
ENSG00000152465 E019 84.7054498 0.0031892202 0.8053530105 0.876200134 10 15132817 15132933 117 - 1.936 1.923 -0.044
ENSG00000152465 E020 91.4852014 0.0003698836 0.1172410796 0.216005396 10 15133053 15133144 92 - 1.988 1.931 -0.192
ENSG00000152465 E021 94.2048644 0.0003171767 0.8161801161 0.883695624 10 15133245 15133363 119 - 1.980 1.973 -0.024
ENSG00000152465 E022 95.3474406 0.0003505236 0.0597460069 0.126188187 10 15135274 15135418 145 - 2.011 1.944 -0.226
ENSG00000152465 E023 6.7027907 0.0042229710 0.6960918189 0.796533582 10 15140987 15141029 43 - 0.902 0.854 -0.183
ENSG00000152465 E024 0.8835061 0.1861780789 0.7849014273 0.862087838 10 15141030 15141353 324 - 0.308 0.256 -0.361
ENSG00000152465 E025 90.1173220 0.0020344468 0.0005567891 0.002372889 10 15141422 15141557 136 - 2.013 1.864 -0.500
ENSG00000152465 E026 65.7674471 0.0054161368 0.0211202246 0.053853630 10 15168503 15168712 210 - 1.873 1.741 -0.444