ENSG00000152464

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000378197 ENSG00000152464 HEK293_OSMI2_2hA HEK293_TMG_2hB RPP38 protein_coding protein_coding 20.01537 23.24322 21.40339 0.5593645 0.823287 -0.1189173 2.952829 3.646529 2.685520 0.1498133 0.6266201 -0.4399113 0.1498375 0.1573667 0.1275667 -0.0298 0.700668246 0.002534855 FALSE TRUE
ENST00000378202 ENSG00000152464 HEK293_OSMI2_2hA HEK293_TMG_2hB RPP38 protein_coding protein_coding 20.01537 23.24322 21.40339 0.5593645 0.823287 -0.1189173 8.961723 12.216717 8.303929 0.6226444 0.7454961 -0.5564347 0.4447125 0.5249333 0.3865333 -0.1384 0.002534855 0.002534855 FALSE TRUE
ENST00000378203 ENSG00000152464 HEK293_OSMI2_2hA HEK293_TMG_2hB RPP38 protein_coding protein_coding 20.01537 23.24322 21.40339 0.5593645 0.823287 -0.1189173 3.642892 3.410365 4.524544 0.3354694 0.3171271 0.4068073 0.1868375 0.1472333 0.2109333 0.0637 0.094323825 0.002534855 FALSE TRUE
ENST00000441850 ENSG00000152464 HEK293_OSMI2_2hA HEK293_TMG_2hB RPP38 protein_coding protein_coding 20.01537 23.24322 21.40339 0.5593645 0.823287 -0.1189173 2.043777 2.186100 1.725591 0.4423367 0.8684535 -0.3395168 0.1009917 0.0933000 0.0835000 -0.0098 0.863819299 0.002534855 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152464 E001 2.1443516 0.0072438620 0.6116089551 0.730702414 10 15097034 15097122 89 + 0.530 0.457 -0.356
ENSG00000152464 E002 7.5229081 0.0266742855 0.1144875791 0.212093606 10 15097123 15097179 57 + 1.024 0.821 -0.766
ENSG00000152464 E003 11.9054759 0.0094415754 0.0770557278 0.154772384 10 15097180 15097214 35 + 1.185 1.015 -0.614
ENSG00000152464 E004 13.4332730 0.0014018935 0.0193432612 0.050076837 10 15097215 15097236 22 + 1.248 1.051 -0.703
ENSG00000152464 E005 28.8178434 0.0008589031 0.0014696179 0.005538497 10 15097237 15097330 94 + 1.562 1.375 -0.644
ENSG00000152464 E006 21.6622994 0.0111065505 0.0360149742 0.083616373 10 15097331 15097354 24 + 1.436 1.266 -0.590
ENSG00000152464 E007 36.1403032 0.0008597786 0.0085990306 0.025285763 10 15097355 15097384 30 + 1.633 1.498 -0.461
ENSG00000152464 E008 41.0052377 0.0007714272 0.0421544399 0.095008473 10 15097385 15097398 14 + 1.666 1.572 -0.318
ENSG00000152464 E009 38.1656761 0.0006191026 0.1826805532 0.304545823 10 15097399 15097409 11 + 1.619 1.561 -0.196
ENSG00000152464 E010 14.6557444 0.0407415962 0.3680412787 0.512448947 10 15097410 15097419 10 + 1.239 1.136 -0.367
ENSG00000152464 E011 27.9341358 0.0008801280 0.6994226061 0.799181626 10 15097420 15097547 128 + 1.457 1.448 -0.030
ENSG00000152464 E012 16.1128028 0.0011076166 0.5836425488 0.707702593 10 15097548 15097569 22 + 1.195 1.257 0.221
ENSG00000152464 E013 58.5437669 0.0037886751 0.7246727969 0.818134664 10 15097570 15097766 197 + 1.750 1.785 0.119
ENSG00000152464 E014 5.7796909 0.0368629496 0.7813414887 0.859543241 10 15097767 15097799 33 + 0.853 0.834 -0.076
ENSG00000152464 E015 67.5676920 0.0004221383 0.0564660791 0.120538721 10 15102218 15102336 119 + 1.867 1.804 -0.211
ENSG00000152464 E016 334.0700312 0.0002179783 0.1079117308 0.202438105 10 15103305 15103713 409 + 2.496 2.541 0.148
ENSG00000152464 E017 341.8449343 0.0035612216 0.0008427536 0.003411404 10 15103714 15104259 546 + 2.469 2.574 0.350
ENSG00000152464 E018 0.8470867 0.0136968632 0.5567179431 0.685301227 10 15104437 15104455 19 + 0.306 0.210 -0.717
ENSG00000152464 E019 3.5105046 0.0154329313 0.0550955747 0.118164327 10 15104456 15105006 551 + 0.786 0.502 -1.232
ENSG00000152464 E020 0.7770552 0.0149299969 0.7690500352 0.850779116 10 15106040 15106130 91 + 0.226 0.286 0.449
ENSG00000152464 E021 0.9879930 0.0174337314 0.3343375211 0.478071692 10 15111686 15111786 101 + 0.374 0.210 -1.131
ENSG00000152464 E022 0.5149111 0.0204045838 0.6470025799 0.758778815 10 15139759 15139818 60 + 0.127 0.210 0.866