ENSG00000152455

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000354919 ENSG00000152455 HEK293_OSMI2_2hA HEK293_TMG_2hB SUV39H2 protein_coding protein_coding 15.5608 6.048543 26.15254 0.6339591 1.913118 2.11046 3.856688 1.97656278 6.293352 0.31623527 0.4533149 1.665845 0.2422208 0.3436333 0.2408333 -0.10280000 0.600884600 0.004295472 FALSE TRUE
ENST00000378331 ENSG00000152455 HEK293_OSMI2_2hA HEK293_TMG_2hB SUV39H2 protein_coding nonsense_mediated_decay 15.5608 6.048543 26.15254 0.6339591 1.913118 2.11046 7.204960 3.27234048 12.262974 0.49460892 0.8317459 1.902688 0.5042208 0.5357667 0.4712333 -0.06453333 0.561746497 0.004295472 FALSE TRUE
ENST00000420416 ENSG00000152455 HEK293_OSMI2_2hA HEK293_TMG_2hB SUV39H2 protein_coding protein_coding 15.5608 6.048543 26.15254 0.6339591 1.913118 2.11046 3.024421 0.09392408 5.442440 0.09392408 1.0654832 5.713300 0.1531917 0.0130000 0.2057333 0.19273333 0.004295472 0.004295472 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152455 E001 3.8275838 0.0422521537 0.1923569888 0.316719722 10 14878820 14878847 28 + 0.688 0.449 -1.099
ENSG00000152455 E002 4.4960866 0.0318211811 0.4539869932 0.594680800 10 14878848 14878862 15 + 0.718 0.604 -0.487
ENSG00000152455 E003 4.8572922 0.0035979377 0.8717842184 0.921540530 10 14878863 14878863 1 + 0.718 0.717 -0.001
ENSG00000152455 E004 5.0024649 0.0032946267 0.7963489171 0.870004421 10 14878864 14878865 2 + 0.732 0.717 -0.060
ENSG00000152455 E005 42.5766109 0.0037423904 0.0002111993 0.001011735 10 14878866 14878899 34 + 1.634 1.389 -0.838
ENSG00000152455 E006 52.2937466 0.0011343384 0.0030754211 0.010488187 10 14878900 14878919 20 + 1.704 1.556 -0.505
ENSG00000152455 E007 2.9644756 0.0051771403 0.1142026809 0.211669311 10 14878920 14878921 2 + 0.620 0.343 -1.395
ENSG00000152455 E008 4.3013821 0.0366573408 0.3904917880 0.534457706 10 14878922 14878960 39 + 0.718 0.600 -0.503
ENSG00000152455 E009 2.4129296 0.0254133690 0.2720920086 0.410932922 10 14878961 14879127 167 + 0.539 0.343 -1.034
ENSG00000152455 E010 1.7130894 0.1240443261 0.8251577429 0.889866050 10 14879454 14879500 47 + 0.382 0.447 0.350
ENSG00000152455 E011 0.1451727 0.0432963015 1.0000000000   10 14879816 14880067 252 + 0.070 0.000 -7.687
ENSG00000152455 E012 38.6795740 0.0005979543 0.4261464736 0.568997223 10 14881500 14881645 146 + 1.548 1.525 -0.076
ENSG00000152455 E013 134.8274749 0.0007347594 0.0052883583 0.016716672 10 14896846 14896977 132 + 2.094 2.022 -0.242
ENSG00000152455 E014 308.7051960 0.0006984249 0.1424077296 0.251324848 10 14896978 14897517 540 + 2.436 2.430 -0.020
ENSG00000152455 E015 196.1658154 0.0002553856 0.8750976714 0.923750779 10 14899539 14899685 147 + 2.233 2.258 0.084
ENSG00000152455 E016 185.1907373 0.0001903765 0.4511002607 0.592104253 10 14901133 14901262 130 + 2.201 2.252 0.170
ENSG00000152455 E017 529.9977903 0.0058818724 0.0075850241 0.022732753 10 14902406 14904315 1910 + 2.640 2.746 0.352