ENSG00000152413

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334082 ENSG00000152413 HEK293_OSMI2_2hA HEK293_TMG_2hB HOMER1 protein_coding protein_coding 4.670378 1.123356 7.963535 0.1145947 0.2503471 2.814619 3.7569392 1.123356 6.1405566 0.1145947 0.16885269 2.440116 0.87014167 1 0.77320000 -0.22680000 9.077422e-06 9.077422e-06 FALSE TRUE
ENST00000460741 ENSG00000152413 HEK293_OSMI2_2hA HEK293_TMG_2hB HOMER1 protein_coding retained_intron 4.670378 1.123356 7.963535 0.1145947 0.2503471 2.814619 0.5415510 0.000000 1.0651481 0.0000000 0.07679372 6.748392 0.08350000 0 0.13446667 0.13446667 8.056513e-05 9.077422e-06   FALSE
ENST00000535690 ENSG00000152413 HEK293_OSMI2_2hA HEK293_TMG_2hB HOMER1 protein_coding protein_coding 4.670378 1.123356 7.963535 0.1145947 0.2503471 2.814619 0.1057957 0.000000 0.4114507 0.0000000 0.41145070 5.397292 0.01331667 0 0.05043333 0.05043333 1.000000e+00 9.077422e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152413 E001 240.001059 0.0111194697 2.352781e-12 5.433049e-11 5 79372636 79375907 3272 - 2.150 2.525 1.250
ENSG00000152413 E002 12.865122 0.0128671599 8.826301e-01 9.288760e-01 5 79375908 79375929 22 - 0.986 1.062 0.278
ENSG00000152413 E003 52.162266 0.0004260515 1.427574e-02 3.885324e-02 5 79375930 79376197 268 - 1.582 1.513 -0.233
ENSG00000152413 E004 39.201178 0.0005582639 1.607645e-03 5.985920e-03 5 79396823 79396903 81 - 1.473 1.308 -0.572
ENSG00000152413 E005 53.823133 0.0015112329 8.817206e-04 3.550251e-03 5 79397527 79397637 111 - 1.604 1.464 -0.480
ENSG00000152413 E006 1.926118 0.0071374182 4.353470e-01 5.775976e-01 5 79397638 79397910 273 - 0.389 0.274 -0.722
ENSG00000152413 E007 57.375330 0.0016204682 6.537541e-03 2.002195e-02 5 79401899 79402055 157 - 1.622 1.537 -0.292
ENSG00000152413 E008 56.106294 0.0005431547 2.701128e-01 4.086964e-01 5 79439010 79439149 140 - 1.595 1.626 0.106
ENSG00000152413 E009 39.812202 0.0005275151 3.926780e-01 5.366010e-01 5 79447053 79447145 93 - 1.453 1.489 0.125
ENSG00000152413 E010 41.794030 0.0115786370 5.063995e-01 6.420533e-01 5 79450990 79451121 132 - 1.473 1.515 0.144
ENSG00000152413 E011 42.928435 0.0005611021 4.108042e-03 1.344580e-02 5 79456862 79457018 157 - 1.503 1.377 -0.435
ENSG00000152413 E012 120.400505 0.0007370535 1.903898e-07 1.831739e-06 5 79512770 79514134 1365 - 1.946 1.802 -0.485