ENSG00000152409

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000396137 ENSG00000152409 HEK293_OSMI2_2hA HEK293_TMG_2hB JMY protein_coding protein_coding 4.325372 2.419035 5.064649 0.1938015 0.2927031 1.062925 2.565538 0.8060973 3.804927 0.08134484 0.0765472 2.2248424 0.5404750 0.3404667 0.7567000 0.4162333 1.959804e-04 5.737799e-06 FALSE TRUE
ENST00000412001 ENSG00000152409 HEK293_OSMI2_2hA HEK293_TMG_2hB JMY protein_coding processed_transcript 4.325372 2.419035 5.064649 0.1938015 0.2927031 1.062925 1.540915 1.5742016 1.015236 0.23617052 0.2287517 -0.6277992 0.4162292 0.6441000 0.1964333 -0.4476667 5.737799e-06 5.737799e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000152409 E001 0.7623952 0.5952872076 9.473764e-01 9.709260e-01 5 79236007 79236130 124 + 0.228 0.208 -0.173
ENSG00000152409 E002 63.7512672 0.0005348213 4.595512e-08 4.993439e-07 5 79236131 79237682 1552 + 1.804 1.560 -0.827
ENSG00000152409 E003 23.5754362 0.0008588574 1.954661e-01 3.205379e-01 5 79277910 79278083 174 + 1.350 1.298 -0.182
ENSG00000152409 E004 23.1728889 0.0009160918 4.682907e-01 6.077123e-01 5 79290121 79290271 151 + 1.330 1.324 -0.020
ENSG00000152409 E005 25.9392745 0.0009929767 1.619915e-01 2.777146e-01 5 79291130 79291299 170 + 1.392 1.336 -0.194
ENSG00000152409 E006 18.7090450 0.0010050778 2.029553e-01 3.299120e-01 5 79300153 79300242 90 + 1.257 1.193 -0.224
ENSG00000152409 E007 17.6923306 0.0066146943 3.881444e-01 5.322563e-01 5 79300243 79300318 76 + 1.226 1.193 -0.116
ENSG00000152409 E008 28.5269042 0.0030296096 2.916025e-01 4.324796e-01 5 79300676 79300863 188 + 1.422 1.393 -0.098
ENSG00000152409 E009 16.4810278 0.0011612451 6.138936e-01 7.324987e-01 5 79306375 79306461 87 + 1.189 1.193 0.016
ENSG00000152409 E010 17.5779389 0.0010905396 8.346579e-01 8.965032e-01 5 79312403 79312498 96 + 1.208 1.241 0.118
ENSG00000152409 E011 20.0803792 0.0010989274 5.542593e-01 6.832648e-01 5 79314257 79314379 123 + 1.269 1.271 0.006
ENSG00000152409 E012 44.3614613 0.0007938346 8.504867e-01 9.072398e-01 5 79314380 79314851 472 + 1.581 1.646 0.222
ENSG00000152409 E013 39.6495180 0.0005179303 9.685650e-01 9.843349e-01 5 79316000 79316310 311 + 1.537 1.588 0.176
ENSG00000152409 E014 209.1128742 0.0007303441 6.795452e-07 5.850654e-06 5 79321606 79324864 3259 + 2.280 2.201 -0.263
ENSG00000152409 E015 222.5236994 0.0078671249 2.864009e-10 4.676590e-09 5 79324865 79327211 2347 + 2.197 2.484 0.960